丙烯醛路线制备3-甲基吡啶研究进展

综述了以丙烯醛为原料制备3-甲基吡啶的研究进展。有氨和催化剂存在的条件下,甲醛、乙醛、丙醛或丙酮均可以和丙烯醛发生反应生成3-甲基吡啶。研究人员对催化剂的性能和产物的分离提纯做了大量的实验。本文认为采用丙烯醛路线对于提高反应选择性具有重要作用,指出该路线的关键问题是解决其自身聚合问题。     

丙烯选择性氧化催化剂性能

通过分步沉淀法制备Mo-Bi-Co-Ni-Fe-K-O复合氧化物催化剂,考察了反应温度、空速和氧烯比等条件对丙烯氧化制备丙烯醛反应中催化性能的影响.结果表明,在反应温度(325～330)℃、空速(1 300～1 700)h-1和n(O2):n(C3H6)=1.5～1.7条件下,丙烯转化率98%,目的产物收率94%.经5...     

国内外丙烯醛检测技术研究进展

综述了国内外丙烯醛检测技术的发展状况,重点介绍了葡萄酒中丙烯醛检测技术。     

新型丙烯醛和丙烯酸催化剂单管工艺试验研究

在模拟工业生产装置上,研究了新型丙烯（C3^=）氧化制丙烯醛（ACR）、ACR氧化制丙烯酸（AA）催化剂的性能,确定了催化剂的操作条件,并在此条件下进行了催化剂稳定性考察。结果表明：C3^=氧化制ACR在空速800－1000h^-1,盐浴温度310℃,C3^=、空气、水的体积比为10：73：17时,C3^=转化率高于98％,ACR收率高于81％,ACR＋AA总收率高于92％,COx收率低于4％;ACR氧化制AA在空速为1420h^-1,盐浴温度为258℃时,ACR转化率高于98％,COx收率低于3％。催化剂运行1000h后的性能良好。     

Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina

Polyamine oxidation plays a major role in neurodegenerative diseases. Previous studies from our laboratory demonstrated that spermine oxidase (SMOX, a member of the polyamine oxidase family) inhibition using MDL 72527 reduced neurodegeneration in models of retinal excitotoxicity and diabetic retinopathy. However, the mechanisms behind the neuroprotection offered by SMOX inhibition are not completely studied. Utilizing the experimental model of retinal excitotoxicity, the present study determined the impact of SMOX blockade in retinal neuroinflammation. Our results demonstrated upregulation in the number of cells positive for Iba-1 (ionized calcium-binding adaptor molecule 1), CD (Cluster Differentiation) 68, and CD16/32 in excitotoxicity-induced retinas, while MDL 72527 treatment reduced these changes, along with increases in the number of cells positive for Arginase1 and CD206. When retinal excitotoxicity upregulated several pro-inflammatory genes, MDL 72527 treatment reduced many of them and increased anti-inflammatory genes. Furthermore, SMOX inhibition upregulated antioxidant signaling (indicated by elevated Nrf2 and HO-1 levels) and reduced protein-conjugated acrolein in excitotoxic retinas. In vitro studies using C8-B4 cells showed changes in cellular morphology and increased reactive oxygen species formation in response to acrolein (a product of SMOX activity) treatment. Overall, our findings indicate that the inhibition SMOX pathway reduced neuroinflammation and upregulated antioxidant signaling in the retina.     

丙烯醛水合加氢法生产1,3-丙二醇过程模拟与技术经济分析

基于丙烯醛水合加氢法制1,3-丙二醇(PDO)的小试和中试结果,应用SuperPro Designer?模拟软件,建立年产万吨PDO的工业放大过程模拟,并进行技术经济分析. 结果表明,主要过程数据符合实验结果,工艺模拟设计合理;经济分析显示,原料成本占生产成本49%,设备购置费用约2242万元,总投资约15088万元,年税后净利润约4256万元,投资回收率28.21%.     

丙烯醛氧化制丙烯酸的改性杂多酸催化剂研制

由丙烯两步氧化法生产丙烯酸的工艺中 ,主要问题在于找到选择性及转化率较好的 ,污染较小的催化剂。本文论述了 P Mo系杂多酸催化剂的性质对催化活性的影响     

双环戊二烯、丙烯醛法生产吡虫啉原药

简要介绍吡虫啉原药的用途和标准,以及采用双环戊二烯和丙烯醛法生产吡虫啉原药的生产工艺和原料要求。详细论述了吡虫啉原药生产的工艺流程,并对工业生产中主要工艺控制点和产品质量进行了讨论。最后提出了生产吡虫啉原药的三废治理方法。     

成环法合成2-氯烟酸

以氰基乙酸乙酯、丙烯醛为原料,经过氯化、重排、迈克尔加成、成环得到2-氯烟酸乙酯,水解得2-氯烟酸,产品经红外光谱、液相色谱和熔点验证。