Shape design of cerium oxide nanoparticles for enhancement of enzyme mimetic activity in therapeutic applications

Cerium oxide nanoparticles (CONPs), widely used in catalytic applications owing to their robust redox reaction, are now being considered in therapeutic applications based on their enzyme mimetic properties such as catalase and super oxide dismutase (SOD) mimetic activities. In therapeutic applications, the emerging demand for CONPs with low cytotoxicity, high cost efficiency, and high enzyme mimetic capability necessitates the exploration of alternative synthesis and effective material design. This study presents a room temperature aqueous synthesis for low-cost production of shape-selective CONPs without potentially harmful organic substances, and additionally, investigates cell viability and catalase and SOD mimetic activities. This synthesis, at room temperature, produced CONPs with particular planes: {111}/{100} nanopolyhedra, {100} nano/submicron cubes, and {111}/{100} nanorods that grew in [110] longitudinal direction. Enzymatic activity assays indicated that nanopolyhedra with a high concentration of Ce⁴⁺ ions promoted catalase mimetic activity, while nanocubes and nanorods with high Ce³⁺ ion concentrations enhanced SOD mimetic activity. This is the first study indicating that shape and facet configuration design of CONPs, coupled with the retention of dominant, specific Ce valence states, potentiates enzyme mimetic activities. These findings may be utilized for CONP design aimed at enhancing enzyme mimetic activities in therapeutic applications.

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Developments in quantitative dimensional synthesis (1970-present): four-bar motion generation

Dimensional synthesis is a type of inverse problem in linkage kinematics where the objective is to calculate the linkage dimensions required to achieve prescribed linkage output motion. Motion generation is a particular category of dimensional synthesis where the objective is to calculate the linkage dimensions required to achieve a group of prescribed link positions. In motion generation for a four-bar linkage, positions are prescribed for the coupler link. While early motion generation methods were primarily qualitative, ongoing advancements in computing hardware and software continue to make quantitative motion generation more practical. By providing overviews of works representative of developments in quantitative four-bar motion generation since 1970, this work is essentially an overview that spans over 40 years of developments in quantitative four-bar motion generation.     

基于视频三音子的双模态语料自动选取算法

为实现可视语音合成,建立符合条件的双模态语料库,提出双模态语料自动选取算法。根据视频中唇部发音特征,对已有的三音子模型归类,形成视频三音子,在其基础上从原始语料中自动选取语料,利用评估函数对原始语料中的句子打分。与其他双模态语料库相比,该语料库在覆盖率等指标上有较大改进,为实现具有真实感的可视语音合成奠定基础。     

Visual Prolog在专家系统故障诊断中的应用

针对故障诊断的特点,利用Visual Prolog语言在知识表示及逻辑推理过程中的优势,以流程工业中易发生事故的催化裂化装置为例设计并实现了基于规则的故障诊断专家系统。用事实和规则这2种构成Visual Prolog语言的短语进行知识库和推理机的编写。通过在催化裂化生产装置的实际应用表明,该诊断系统效果良好,能够对出现的多数异常工况进行有效的推理及分析,及时查找出故障原因,并提供相应的故障处理措施。     

基于贝叶斯最大化后验估计方法的图片合成模型研究

在图像处理应用中,常常需要根据一些列相关的输入图片生成一张新的图片。现有的研究大都设定一些启发式规则用于图片的合成过程。为了提高图片合成的性能,提出了一种基于改进的贝叶斯方法的图片合成模型。在给定理想的图片合成模型后,对传感器误差和图片误差进行了分析。由于图片误差和几何误差之间是相关的,因此分析了它们之间的关系。在根据已有数据对模型进行后验估计时,通过最小化能量来得到模型的先验参数。在目标函数的优化过程中,基于现有研究通过重新赋权值的迭代方法进行优化问题的求解。最后,通过大量的实验表明,所提出的图片合成模型与相关方法相比具有更好的图片合成和渲染效果。     

逻辑综合在数字IC设计中的应用

随着数字IC的规模和复杂性不断增加,数字IC设计的难度也在加大,为了更好地进行数字IC设计,业界普遍采用了自动化的设计方式,通过应用工具软件,将IC设计的效率极大地提高.主要探讨了在IC设计当中逻辑综合方面的问题.     

Low order integral-action controller synthesis

A simple controller synthesis method is developed for certain classes of linear, time-invariant, multi-input multi-output plants. The number of poles in each entry of these controllers depends on the number of right-half plane plant zeros, and is independent of the number of poles of the plant to be stabilized. Furthermore, these controllers have integral-action so that they achieve asymptotic tracking of step input references with zero steady-state error. The designed controller’s poles and zeros are all in the stable region with the exception of one pole at the origin for the integral-action design requirement. The freedom available in the design parameters may be used for additional performance objectives, although the only goal here is stabilization and tracking of constant references.     

车用尾气催化转化器结构的计算辅助设计与分析系统

采用ＡｕｔｏＬＩＳＰ语言,编制了运行于ＡｕｔｏＣＡＤ平台上的车用尾催化转化器结构的计算辅助设计与分析系统。该系统结合了参数化设计与性能分析功能,并采用对话框驱动执行的方式,使系统的使用具有直观、方便的特点,可为车用尾气催化转化器的研制工作提供有益帮助。,     

对DAG-MAP算法的研究

DAG－MAP是一个面向延迟优化的FPGA工艺映射算法,其中的标记过程是该算法的核心.文章对原算法中的标记过程进行了研究,并且提出了一个改进的标记方法.通过对MCNC标准测试电路的实验结果表明该算法比原算法更为有效,并且算法所用时间没有明显的增加.