湖北宜昌镁橄榄岩矿床地质特征及其成因探讨

矿床位于宜昌大平溪超基性岩体中段,由弱蛇纹石化或未蚀变的巨晶纯橄榄岩组成。按氧化镁含量及灼失量圈定的镁橄榄岩,为一向西侧伏的扁豆体。岩石为巨晶不等粒、似斑状结构,快状构造,矿物以镁橄榄石为主,粒径一般20～30mm,最大>100mm,多为半自形晶。岩石化学成分:MgO4O.88％～48.41％,CaO<0.95％,Al_2O_3<0.87％,灼失量一般<6.77％。耐火度一般为1630°～1710℃,最高达1770℃,与国内外镁橄榄岩相同。本文以实际资料,证实镁橄榄岩是较均一的超基性岩浆,在温度缓慢下降时,结晶分异生成的折离体,属岩浆分异矿床。     

设计空间差别处理优化方法及其在汽车轻量化设计中的应用

提出了一种设计空间差别处理方法,改进了传统的设计空间移除方法会移除全局最优的弱点。首先应用昂贵点构建一个逐渐缩小的重点空间,同时将在设计空间移除方法中被删除的空间定义为其他空间,然后每次迭代都应用二阶多项式响应面（QF）同时搜索这两类空间,并分别从中选取数目不同的新的昂贵点参与QF的更新和重建。该方法采用在其他空间中选择少量新的昂贵点来代替移除空间,有效地避免了局部最优的陷阱。多个标准函数算例的验证表明,新的方法具有较高的精度和效率。将该方法应用于某款车的后车架轻量化设计中,经过优化,后车架系统的质量减小了7.67kg,即整个系统质量减小了10.4%,且其刚度性能得到提高。与以前提出的混合自适应元模型方法相比,新方法的精度和效率都有显著提高。     

基于5G网络切片技术的农网智能监控传输应用

基于5G(5th-Generation,第五代移动通信技术)网络背景,根据电网差异化场景定制、多种类数据承载需求,以网络切片架构原理和实现技术为起点,重点针对农村网络(农网)智能监控中覆盖范围存在盲区、信息传输无法实时同步、视频清晰度欠佳等常见问题,提出一种多元化信息的切片传输方案,详细阐述方案原理架构及实现思路.通过...     

矿山岩体破坏微震分异速率特征及预警研究

在矿山岩体破坏预警研究中,探究岩体损伤特征规律及给出具体预警参数值对保障矿山安全至关重要。本文以某金属矿山为例,基于微震监测技术建立地压监测系统,结合该矿山某次顶板大范围冒落事件,采用主成分分析法确定最佳统计时间窗口,对顶板冒落事件前后微震时空演化特征进行分析。分析表明微震事件密度云图中心位置与破坏位置相一致,在岩体破坏前微震数量有持续增多,达到峰值后又迅速下降的前兆信息。以微震数量方差表示微震分异程度,以此表征岩体受损程度,采用有限差分法得出微震事件分异速率指标,研究表明岩体破坏过程微震分异速率分为稳定分异阶段、加速分异阶段和岩体破坏3个阶段。稳定分异阶段分异速率呈正态分布,采用Gauss Amp函数对其进行拟合,最终得出置信度为0.99的将区间上限0.306确定为分异速率预警值。该研究为采用微震监测技术的矿山灾害预警系统建立提供理论基础,对矿山安全生产管理具有一定借鉴意义。     

Biophysical Modulation of Mesenchymal Stem Cell Differentiation in the Context of Skeletal Repair

A prominent feature of the skeleton is its ability to remodel in response to biophysical stimuli and to repair under varied biophysical conditions. This allows the skeleton considerable adaptation to meet its physiological roles of stability and movement. Skeletal cells and their mesenchymal precursors exist in a native environment rich with biophysical signals, and they sense and respond to those signals to meet organismal demands of the skeleton. While mechanical strain is the most recognized of the skeletal biophysical stimuli, signaling phenomena also include fluid flow, hydrostatic pressure, shear stress, and ion-movement-related electrokinetic phenomena including, prominently, streaming potentials. Because of the complex interactions of these electromechanical signals, it is difficult to isolate the significance of each. The application of external electrical and electromagnetic fields allows an exploration of the effects of these stimuli on cell differentiation and extra-cellular matrix formation in the absence of mechanical strain. This review takes a distinctly translational approach to mechanistic and preclinical studies of differentiation and skeletal lineage commitment of mesenchymal cells under biophysical stimulation. In vitro studies facilitate the examination of isolated cellular responses while in vivo studies permit the observation of cell differentiation and extracellular matrix synthesis.     

MiR-320-3p Regulates the Proliferation and Differentiation of Myogenic Progenitor Cells by Modulating Actin Remodeling

Skeletal myogenesis is essential for the maintenance of muscle quality and quantity, and impaired myogenesis is intimately associated with muscle wasting diseases. Although microRNA (miRNA) plays a crucial role in myogenesis and relates to muscle wasting in obesity, the molecular targets and roles of miRNAs modulated by saturated fatty acids (SFA) are largely unknown. In the present study, we investigated the role of miR-320-3p on the differentiation of myogenic progenitor cells. Palmitic acid (PA), the most abundant dietary SFA, suppressed myogenic factors expression and impaired differentiation in C2C12 myoblasts, and these effects were accompanied by CFL2 downregulation and miR-320-3p upregulation. In particular, miR-320-3p appeared to target CFL2 mRNA directly and suppress the expression of CFL2, an essential factor for filamentous actin (F-actin) depolymerization. Transfection of myoblasts with miR-320-3p mimic increased F-actin formation and nuclear translocation of Yes-associated protein 1 (YAP1), a key component of mechanotransduction. Furthermore, miR-320-3p mimic increased myoblast proliferation and markedly impeded the expression of MyoD and MyoG, consequently inhibiting myoblast differentiation. In conclusion, our current study highlights the role of miR-320-3p on CFL2 expression, YAP1 activation, and myoblast differentiation and suggests that PA-inducible miR-320-3p is a significant mediator of muscle wasting in obesity.     

基于梯度树的光学层析正则化重建

光学层析成像是一个病态重建过程,为降低重建过程中的病态特性,需加入合适的先验信息。目前,大多数重建都是基于扩散方程的,在某些情况下,这种重建会失败。直接基于玻耳兹曼传输模型,并以图像熵为正则化项的梯度迭代重建是一种有效的方法。该方法中,梯度计算是个难点。对此,提出一种基于梯度树的求解方法,降低光学层析图像重建的病态性,有效地重建光学层析图像。     

Magnesium Modified β-Tricalcium Phosphate Induces Cell Osteogenic Differentiation In Vitro and Bone Regeneration In Vivo

In vitro, in vivo, and clinical studies have shown how the physicochemical and biological properties of β-tricalcium phosphate (β-TCP) work in bone regeneration. This study aimed to improve the properties of β-TCP by achieving optimum surface and bulk β-TCP chemical/physical properties through the hydrothermal addition of magnesium (Mg) and to later establish the biocompatibility of β-TCP/Mg for bone grafting and tissue engineering treatments. Multiple in vitro and in vivo analyses were used to complete β-TCP/Mg physicochemical and biological characterization. The addition of MgO brought about a modest rise in the number of β-TCP surface particles, indicating improvements in alkaline phosphatase (ALP) activity on day 21 (p < 0.05) and in the WST-1assay on all days (p < 0.05), with a corresponding increase in the upregulation of ALP and bone sialoprotein. SEM analyses stated that the surfaces of the β-TCP particles were not altered after the addition of Mg. Micro-CT and histomorphometric analysis from rabbit calvaria critical defects resulted in β-TCP/Mg managing to reform more new bone than the control defects and β-TCP control at 2, 6, and 8 weeks (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, and **** p ≤ 0.0001). The hydrothermal addition of MgO to the β-TCP surfaces ameliorated its biocompatibility without altering its surface roughness resulting from the elemental composition while enhancing cell viability and proliferation, inducing more bone regeneration by osteoconduction in vivo and osteoblastic differentiation in vitro.     

Kinetic parameter estimation for cooling crystallization process based on cell average technique and automatic differentiation

In this paper, a cell average technique(CAT) based parameter estimation method is proposed for cooling crystallization involved with particle growth, aggregation and breakage, by establishing a more efficient and accurate solution in terms of the automatic differentiation(AD) algorithm. To overcome the deficiency of CAT that demands high computation cost for implementation, a set of ordinary differential equations(ODEs) entailed from CAT based discretized population balance equation(PBE) are solved by using the AD based high-order Taylor expansion. Moreover, an AD based trust-region reflective(TRR) algorithm and another interior-point(IP) algorithm are established for estimating the kinetic parameters associated with particle growth, aggregation and breakage. As a result, the estimation accuracy can be further improved while the computation cost can be significantly reduced, compared to the existing algorithms. Benchmark examples from the literature are used to illustrate the accuracy and efficiency of the AD-based CAT, TRR and IP algorithms in comparison with the existing algorithms. Moreover, seeded batch cooling crystallization experiments of β form L-glutamic acid are performed to validate the proposed method.