硬件产品故障注入测试研究

对DCS控制系统硬件产品的故障注入测试进行了研究,主要用于指导产品的硬件故障注入测试,通过故障注入测试更好地挖掘产品在设计方面的缺陷和不足,推动产品质量的提升。研究主要包含建立故障模型、故障注入测试方法、故障注入测试工具及平台等几个方面的内容。产品的硬件故障注入测试研究,是根据产品的应用环境,积累故障模型,测试时从故障模型库中提取故障模型,使用合理的故障注入方式,借助测试工具将故障注入到目标电路的过程,并监测产品在故障状态下的表现情况,根据测试标准进行正确的判断。故障注入测试技术是产品可靠性测试技术的重要内容,是一种行之有效的提高产品质量的手段。     

Fullerene材料的现状与发展趋势

富勒烯（Ｆｕｌｅｒｅｎｅ）和碳纳米管（ＣＮＴ）可能是本世纪末材料科学领域最重大的发现之一。进入９０年代以来，其制备方法、物化特性及可能的应用领域等成为人们的研究热点，并对材料物理、微电子、介观量子效应等众多科研领域产生了重大的冲击。根据目前进展，富勒烯／碳纳米管的应用研究很可能首先在ＣＮＴ缺陷研究、分子工具（Ｍｏｌｅｃｕｌａｒｔｏｏｌｓ）、纳米装置（Ｎａｎｏ－ｄｅｖｉｃｅ）应用和新一代贮能材料等方面取得突破。     

电火花线切割机导轮组合件装配及相关问题的解决

导轮组合件是电火花线切割机床的重要组成部分,对机床和工件的质量有着重要影响。介绍了运用专用工具对电火花线切割机床导轮组合件进行装配的方法,并对装配过程中存在的问题进行了详细分析,提出了相应的解决措施。     

CCD摄象技术在线纹量具生产中的应用

讨论了用电荷耦合器对件对线纹量具进行非接触测量的理论与方法,介绍了一种笔者实践过的应用系统并阐述了系统的计算机控制原理。     

快速加工圆柱直齿轮的展成拉齿工艺

针对圆柱齿轮传统滚齿、铣齿加工效率偏低的问题,提出了展成拉齿加工的工艺方案,从专用刀具、展成切削原理和加工效率计算等方面入手,从理论上分析了该工艺的优越性,例举了双齿条分度机构改装方案,客观论证了圆柱齿轮展成拉齿加工工艺的成熟可靠性。     

陶瓷刀具的切削性能及其应用

阐述了陶瓷刀具的切削性能和在实际应用中应该注意的问题,为在机械加工行业中推广应用陶瓷刀具作初步的探讨。     

Research on virtual dynamic optimization design for NC machine tools

Virtual dynamic optimization design can avoid the repeated process from design to trial-manufacture and test. The designer can analyze and optimize the product structures in virtual visualization environment. The design cycle is shortened and the cost is reduced. The paper analyzed the peculiarity of virtual optimization design, and put forwards the thought and flow to implement virtual optimization design. The example to optimize the internal grinder was studied via establishing precise finite element model, modifying the layout of Stiffened Plates and designing parameters of the worktable, and using the technology of modal frequency revision and the technology of multiple tuned damper. The result of optimization design compared the new grinder with the original grinder shows that the entire machine＇s first orders natural frequency is enhanced by 17%, and the response displacement of the grinding-head has dropped by 28% under the first order natural frequency and by 41% under second order natural frequency. Finally, the dynamic performance of the internal grinder was optimized.     

回转轴运动精度的干涉测量与误差补偿分析

采用激光干涉仪检测混联数控机床回转轴的运动精度,达到对其综合评价的目的,为机床的运动精度误差补偿做准备.对雷尼绍激光干涉仪的结构和角度测量原理进行了详细探讨,分析了干涉仪在回转轴运动精度测量中的主要影响因素和误差诱因;作出了角度测量中正弦近似误差特性曲线,并提出了该测量误差的数学模型;讨论了激光波长补偿的机理,提出了一种通用、简便易行的回转轴角位移精度检测方法.     

Identification of Spliceogenic Variants beyond Canonical GT-AG Splice Sites in Hereditary Cancer Genes

Pathogenic/likely pathogenic variants in susceptibility genes that interrupt RNA splicing are a well-documented mechanism of hereditary cancer syndromes development. However, if RNA studies are not performed, most of the variants beyond the canonical GT-AG splice site are characterized as variants of uncertain significance (VUS). To decrease the VUS burden, we have bioinformatically evaluated all novel VUS detected in 732 consecutive patients tested in the routine genetic counseling process. Twelve VUS that were predicted to cause splicing defects were selected for mRNA analysis. Here, we report a functional characterization of 12 variants located beyond the first two intronic nucleotides using RNAseq in APC, ATM, FH, LZTR1, MSH6, PALB2, RAD51C, and TP53 genes. Based on the analysis of mRNA, we have successfully reclassified 50% of investigated variants. 25% of variants were downgraded to likely benign, whereas 25% were upgraded to likely pathogenic leading to improved clinical management of the patient and the family members.     

改进缺陷,套刻和聚焦性能的第五世代浸没式曝光系统

论述了第五世代双扫描平台浸液式扫描曝光机的性能和进展。表明了在高速扫描状态下有生产价值的套刻和聚焦性能的实现。浸液式设备更多的关键部分与缺陷有关,而且该机的改进是通过有生产价值的缺陷水平方面来体现的。为了保持这种缺陷水平的改进效果,需要在圆片应用中进行专门稳定的测量。特加是边缘空泡除去(EBR)设计和圆片斜面良流线性是很重要的。