基于TS-NGA的多作战智能体制导-攻击匹配优化

空中制导-攻击匹配(GAM)旨在确定武器单元、制导单元以及目标三者之间的最优匹配关系,以使多作战智能体任务联盟整体作战效能最大。分析了基于混合通信方式的多作战智能体制导-攻击匹配过程,建立制导攻击匹配约束优化问题模型,设计了一种禁忌策略的嵌套遗传算法(TS-NGA)对模型进行求解,算法的外层循环寻求武器单元和制导单元的最优配对,内层循环寻求武器单元和目标的最优配对。针对GAM问题特点,制定了编码与解码策略、交叉、变异规则以及选择、禁忌策略。仿真实验结果表明所设计求解算法能较好地解决三维变量的GAM问题模型。     

一种新型的樽海鞘群算法及其应用

为了解决樽海鞘群算法SSA在寻优过程中存在收敛速度慢、计算精度差等问题,提出一种新型的樽海鞘群算法NSSA。首先分析SSA中樽海鞘在追随领导者过程中的不足,然后借鉴灰狼优化算法中追随头狼的思想来改进樽海鞘追随领导者的方式。在23个基准函数上对NSSA与其他算法进行性能比较,并把该算法应用于图像匹配之中。所有实验结果表明,NSSA具有更好的收敛速度、计算精度和鲁棒性。     

Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase

Phenylketonuria (PKU) is a rare metabolic disease caused by variations in a human gene, PAH, encoding phenylalanine hydroxylase (PAH), and the enzyme converting the essential amino acid phenylalanine into tyrosine. Many PKU-causing variations compromise the conformational stability of the encoded enzyme, decreasing or abolishing its catalytic activity, and leading to an elevated concentration of phenylalanine in the blood, which is neurotoxic. Several therapeutic approaches have been developed to treat the more severe manifestations of the disorder, but they are either not entirely effective or difficult to adhere to throughout life. In a search for novel pharmacological chaperones to treat PKU, a lead compound was discovered (compound IV) that exhibited promising in vitro and in vivo chaperoning activity on PAH. The structure of the PAH-IV complex has been reported. Here, using alchemical free energy calculations (AFEC) on the structure of the PAH-IV complex, we design a new generation of compound IV-analogues with a higher affinity for the enzyme. Seventeen novel analogues were synthesized, and thermal shift and isothermal titration calorimetry (ITC) assays were performed to experimentally evaluate their stabilizing effect and their affinity for the enzyme. Most of the new derivatives bind to PAH tighter than lead compound IV and induce a greater thermostabilization of the enzyme upon binding. Importantly, the correspondence between the calculated alchemical binding free energies and the experimentally determined ΔΔG_b values is excellent, which supports the use of AFEC to design pharmacological chaperones to treat PKU using the X-ray structure of their complexes with the target PAH enzyme.     

OPTIMIZING LAYOUT OF URBAN STREET CANYON USING NUMERICAL SIMULATION COUPLING WITH MATHEMATICAL OPTIMIZATION

1. INTRODUCTION Vehicular emissions have become one of thmain sources of urban atmospheric pollution in Chinwith the development of the urban construction andthe increase in the number of vehicles. There are lots of factors influencing the transport and dispersion of vehicular exhausted pollutants and further influencing the local air quality, among which the gas dynamical effect due to the mechanical turbulence from huge buildings and street canyons is especially remarkable. Previous stu…     

东海西湖井身结构深度优化技术及其应用

东海西湖地区深部地层具有研磨性强,可钻性差,机械钻速低,且存在异常高温高压等特点。通过不断探索、实践井身结构优化技术,形成了东海近几年较为固定的探井井身结构。但表层?444.5 mm井眼再加速遭遇“瓶颈”,常压深井井身结构仍有优化空间。随着东海钻井技术的不断进步及油气资源勘探开发的需求,水平井及大斜度井的数量在不断增多,而开发井?215.9 mm井眼水平段?177.8 mm尾管下入困难。因此,需要进一步对东海西湖凹陷区域井身结构进行深度优化。针对以上难点,研究形成了表层井眼尺寸优化技术、深井井身结构简化技术及开发井尾管尺寸优化技术。现场试验应用表明,钻井提速效果明显,为后续井的井身结构继续优化奠定了基础。同时也降低了深部井段复杂情况出现的概率,增大了探井套管和井眼环空间隙,为后续作业提供了便利,也为复杂地质条件下深井和超深井的井身结构的设计提供了新的思路。     

Composing fifth species counterpoint music with a variable neighborhood search algorithm

In this paper, a variable neighborhood search (VNS) algorithm is developed and analyzed that can generate fifth species counterpoint fragments. The existing species counterpoint rules are quantified and form the basis of the objective function used by the algorithm. The VNS developed in this research is a local search metaheuristic that starts from a randomly generated fragment and gradually improves this solution by changing one or two notes at a time. An in-depth statistical analysis reveals the significance as well as the optimal settings of the parameters of the VNS. The algorithm has been implemented in a user-friendly software environment called Optimuse. Optimuse allows a user to input basic characteristics such as length, key and mode. Based on this input, a fifth species counterpoint fragment is generated by the system that can be edited and played back immediately.     

600MW空冷机组锅炉烟风道优化设计分析

针对600 MW空冷机组原烟风道占地面积大,材料用量多、造价高的问题,结合河北建投沙河发电有限公司2台600 MW超临界空冷机组工程中烟风道的设计,比较分析烟风道采用常规矩形道体和圆形道体的优劣,认为烟风道道体优化形状为圆形,介绍除尘器进口烟道、热一次风道、引风机进口烟道优化布置方案,并进行经济性分析。     

基于微分进化算法的发电商机组出力综合性优化策略

提出了一种新的基于改进微分进化算法的电力市场机组出力综合性优化策略。根据机组出力与市场电价之间的协调联动关系,以交易日售电总利润最大化为目标,综合考虑机组运行成本、阀点效应、环境保护成本、实际报价风险系数,构建了交易日机组分时段出力优化模型,由此得出机组的综合性发电优化方案。设计了一种加入随机扰动因子进行变异以克服收敛早熟的微分进化算法对所构建的具有非线性、非凸特性的动态规划模型进行快速准确地求解。算例的仿真分析结果验证了该方法的可行性和优越性。     

RBFEM在电场快速优化设计中的应用

针对高压电器设备电场优化设计常用有限元法(FEM)结合非线性规划法,设计变量改变后需要不断重复FEM的一系列计算过程,存在着大量的重复计算,从而引起计算量大大增加。为此,笔者引入了缩减基有限元法(RBFEM),推导了基于缩减基法的有限元方程。RBFEM通过计算维数大大减小的缩减基矩阵,使得整个优化过程的计算量大大减小。利用该算法,对500 kV电力变压器设备的绝缘结构进行了优化设计,每计算一次有限元方程,缩减基法需要的时间是FEM的1/4,可大大提高优化效率。同时和利用商业有限元软件计算优化后变压器绝缘结构的电场强度值比较,误差不超过1%,验证了该算法的有效性。     

联合采用多代理和禁忌方法的系统恢复策略

将多代理技术MAT的分布式信息处理和禁忌方法TSM有机结合,形成了一种新型分布式电力系统恢复模型。模型由多结点智能代理GIAGs(crunode intelligent agents)和一个智能控制代理ICAG(intelligent control agent)组成,通过多个CIAGs间交互协商处理及ICAG的基于TSM的协同求解,能够实现快速恢复决策。仿真结果表明,该模型不仅能够快速获得恢复优化策略,而且对网络拓扑结构变化具有较强的适应性。