稀土钕对激光快速成形TC4合金组织及性能的影响

针对氢化脱氢钛合金粉末氧含量较高的问题，研究了添加稀土钕对激光快速成形TC4合金组织及性能的影响。结果发现，添加稀土Nd后，激光快速成形TC4合金的宏观晶粒尺寸变化不大；但随稀土添加量的增加，初始β列状晶逐渐转化为全β等轴晶，晶粒内部的魏氏α组织逐渐转变为网篮α，粗化α条不断增多，呈现团束聚集趋势，晶界α集束体积分数也不断增大；随稀土添加量的增加，激光快速成形TC4合金的室温塑性先大幅度提高，然后急剧降低；稀土添加量为0．1％～0．2％（质量分数，下同）时，氧含量为0．26％的氢化脱氢TC4合金粉末激光快速成形件沉积态的抗拉强度达975MPa，延伸率9．5％，满足锻件标准要求。     

铝阳极氧化膜颜色的检验和观察法

介绍铝及铝合金阳极氧化膜颜色的概念和描写,对颜色的儿种测量方法进行了比较,重点分析观察法及其在各国标准中的异同。在此基础上,提出了GB8013中的对颜色进行观察的条件和理论根据。     

新工艺技术在合金钢棒线材生产中的应用

分析了目前我国棒线材市场优质合金钢棒线材稀缺形势下,用先进的新工艺技术改造合金钢棒线材生产线具有现实意义。这些新技术包括:连铸坯热送热装、脱头轧制和二次加热、精密轧制、低温精轧、单一孔型和"自由尺寸"轧制、直条棒材在线缓冷和刷毛刺、奥氏体不锈钢线材在线散卷固溶处理和盘卷在线环型炉固溶处理、不锈钢盘卷酸洗等技术。     

从铜镉渣中回收镉的试验研究

本文介绍了从铜镉渣中回收镉的试验研究情况，采用酸浸-铜镉渣中和-锌粉除铜法处理铜镉渣，工艺简单合理，镉直收率高，有一定的推广价值。     

应用人工神经网络理论建立热粘塑性材料的本构关系

本文将人工神经网络（ＡＮＮ）用于建立热粘塑性材料的本构关系，意在探索出一种描述材料变形力学行为的新方法。文中给出了应用人工神经网络建立热粘塑性材料本构关系的ＢＰ模型和学习算法过程，并应用于４５号钢在高温和高速变形条件下的流动应力计算。计算结果与实测结果比较表明，二者吻合良好。因此，应用人工神经网络建立热粘塑性材料的本构关系具有重要的工程应用价值。     

考虑客户画像和能量枢纽的配电网多目标抢修重构模型

随着大规模风电以及能量枢纽接入配电网,配电网故障后抢修重构面临新挑战,提出一种考虑客户画像和能量枢纽的配电网多目标多故障抢修重构模型。通过对配电网用电客户多因素精准画像,确定权重,建立兼顾客户画像和能量枢纽的配电网多目标抢修重构模型,提出一种改进NSGA-II算法以适应对模型求解,从而获得Pareto解集,并利用模糊最大满意度进行决策。算例仿真表明所提模型正确有效,与传统模型相比更加精细而客观。     

MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts

Tumor-infiltrating immune cells phenotype is associated with tumor progression. However, little is known about the phenotype of the peripheral blood mononuclear cells (PBMC) from breast cancer patients. We investigated MMP1 and MMP11 expression in PBMC from breast cancer patients and we analyzed gene expression changes upon their interaction with cancer cells and cancer-associated fibroblasts (CAF). We measured the impact of PBMC on proinflammatory gene expression in breast cancer cells, normal fibroblast (NF), and CAF and the impact on proliferation and invasiveness capacity of breast cancer cells. Gene expression of MMP1 and MMP11 in PBMC from breast cancer patients (n = 54) and control (n = 28); expression of IL1A, IL6, IL17, IFNβ, and NFĸB in breast cancer cell lines (MCF-7 and MDA-MB-231); and, additionally, IL10 and MMP11 in CAF and NF were analyzed by qRT-PCR before and after co-culture. Our results show the existence of a subpopulation of breast cancer patients (25.9%) with very high levels of MMP11 gene expression in PBMC. Also, gene expression of MMP1 and MMP11 increases in PBMC after co-culture with breast cancer cell lines, NF or CAF. PBMC from healthy or breast cancer patients induce an increased proliferation rate on MCF-7 and an increased invasiveness capacity of MDA-MB-231. Finally, we show a differential expression profile of inflammatory genes in NF and CAF when co-cultured with control or breast cancer PBMC. We have observed that MMPs’ expression in PBMC is regulated by the microenvironment, while the expression of inflammatory genes in NF or CAF is differentially regulated by PBMC. These findings confirm the importance of the crosstalk between stromal cells and suggest that PBMC would play a role in promoting aggressive tumor behavior.     

IgGs-Abzymes from the Sera of Patients with Multiple Sclerosis Recognize and Hydrolyze miRNAs

Autoantibodies-abzymes hydrolyzing DNA, myelin basic protein, and oligosaccharides have been revealed in the sera of patients with multiple sclerosis (MS). In MS, specific microRNAs are found in blood and cerebrospinal fluid, which are characterized by increased expression. Autoantibodies, specifically hydrolyzing four different miRNAs, were first detected in the blood of schizophrenia patients. Here, we present the first evidence that 23 IgG antibodies of MS patients effectively recognize and hydrolyze four neuroregulatory miRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219-5p) and four immunoregulatory miRNAs (miR-21-3p, miR-146a-3p, miR-155-5p, and miR-326). Several known criteria were checked to show that the recognition and hydrolysis of miRNAs is an intrinsic property of MS IgGs. The hydrolysis of all miRNAs is mostly site-specific. The major and moderate sites of the hydrolysis of each miRNA for most of the IgG preparations coincided; however, some of them showed other specific sites of splitting. Several individual IgGs hydrolyzed some miRNAs almost nonspecifically at nearly all internucleoside bonds or demonstrated a combination of site-specific and nonspecific splitting. Maximum average relative activity (RA) was observed in the hydrolysis of miR-155-5p for IgGs of patients of two types of MS—clinically isolated syndrome and relapsing-remitting MS—but was also high for patients with primary progressive and secondary progressive MS. Differences between RAs of IgGs of four groups of MS patients and healthy donors were statistically significant (p < 0.015). There was a tendency of decreasing efficiency of hydrolysis of all eight miRNAs during remission compared with the exacerbation of the disease.     

A Random Nonstationary Pulse Train Model

A simple and mathematically tractable model of a nonstationary process is developed.The process is the sum of waves where the parameters of the waves are random. Explicit expressions for the mean and autocorrelation function at each position as a function of time are obtained.In the case of infinite time, the model evolves into a stationary process. The time-frequency distribution at each position is also obtained. An explicit example is given where the initial waves are Gaussian. The case where there is dispersion in the propagation is also discussed.     

中国耕地细碎化的理论解析与研究框架

基于演绎推理法和文献研究法,探索耕地细碎化的概念、过程、机制和效应,并构建耕地细碎化研究框架,为耕地细碎化研究提供理论指导。结果表明:①耕地细碎化是耕地在自然-人为双重因素驱动下,耕地地块在形态上不断分割、变小,耕地产权在主体上不断细分、多元的过程,并分别表现为相互关联又有所区别的耕地景观细碎化和耕地权属细碎化; ②耕地细碎化研究应遵循“诊断-机制-效应-治理”的理论框架,耕地细碎化诊断需从形态和权属两方面构建评价指标体系,形成机制可从自然切割力、利用切割力、设施切割力和管理切割力4个方面揭示不同因素的作用机制,效应需揭示不同尺度下耕地细碎化形态和产权的趋势性转折对经济、社会和生态的影响,治理研究应按照“问题识别治理潜力治理路径保障措施”的逻辑顺序构建。