Laminin as a Biomarker of Blood–Brain Barrier Disruption under Neuroinflammation: A Systematic Review

Laminin, a non-collagenous glycoprotein present in the brain extracellular matrix, helps to maintain blood–brain barrier (BBB) integrity and regulation. Neuroinflammation can compromise laminin structure and function, increasing BBB permeability. The aim of this paper is to determine if neuroinflammation-induced laminin functional changes may serve as a potential biomarker of alterations in the BBB. The 38 publications included evaluated neuroinflammation, BBB disruption, and laminin, and were assessed for quality and risk of bias (protocol registered in PROSPERO; CRD42020212547). We found that laminin may be a good indicator of BBB overall structural integrity, although changes in expression are dependent on the pathologic or experimental model used. In ischemic stroke, permanent vascular damage correlates with increased laminin expression (β and γ subunits), while transient damage correlates with reduced laminin expression (α subunits). Laminin was reduced in traumatic brain injury and cerebral hemorrhage studies but increased in multiple sclerosis and status epilepticus studies. Despite these observations, there is limited knowledge about the role played by different subunits or isoforms (such as 411 or 511) of laminin in maintaining structural architecture of the BBB under neuroinflammation. Further studies may clarify this aspect and the possibility of using laminin as a biomarker in different pathologies, which have alterations in BBB function in common.     

基于小波分析的听觉滤波器组模型

对听觉滤波器组模型进行了研究。比较分析了伽马通(Gammatone)听觉滤波器组模型和基于小波分析的高斯小波听觉滤波器组模型,分别给出了预测听阈曲线并且与标准听闻曲线进行了比较,结果表明高斯小波听觉滤波器组模型更接近实际人耳滤波效果。将高斯小波听觉滤波器组模型的预测特征响度与德国朗德(Head Acoustics)公司的Artemis软件计算出的特征响度进行分析比较,结果表明,每个特征频带的响度差值都小于0.6 sone。     

单试样三点柔度法测金属材料JR曲线及其条件起裂值

在单试样卸载柔度法及单试样三曲线法基础上,提出了一种更简便的测定金属材料ＪＲ曲线及其条件起裂值的单试样三点预先度法,并用该方法测定了１Ｃｒ１／２Ｍｏ钢、１６ＭｎＲ风和ＷＣＦ６２钢的ＪＲ曲线及其条件起裂值,与标准的多试样法相比,误差均在工程许可范围内。     

超高压汞灯配光曲线的自动测量

为了准确获得超高压汞灯配光曲线数据，通过分析光源尺寸以及光源与探测器距离对测量结
果的影响，利用计算机接口技术和光电转换技术构建一套自动测量装置对超高压汞灯的配光曲线进行自动
测量。利用程序延时以及软件滤波消除超高压汞灯驱动电流、电压、测量装置机械振动对测量结果的影响
，从而提高了测量数据的准确性和稳定性。装置测量所得数据不仅可以满足投影系统仿真对配光曲线精度
的要求，而且可以为超高压汞灯的泡壁和电极设计提供参考。     

关于张家口住宅开发市场的思考

合理的户型设计将成为未来住宅市场上的核心竞争力．通过分析当前张家口住宅产业发展现状和市场需求,提出了进行中小套型住宅的开发策略．     

建议增用主曲线实验方法提高我国核电安全的可靠性

日本福岛核事故后,各国政府对核电厂的安全更加重视了。提高核电厂安全要求非常重要,予以实现更加重要。毫无疑问,为安全所采取的新措施必须满足标准要求,并被世界公认和各国共同采用后,才会被核电厂接受和推行。本文的建议符合此原则并在文中说明了原因和根据。     

Orientationability analyses of a special class of the Stewart–Gough parallel manipulators using the unit quaternion representation

This paper addresses the orientation-singularity and orientationability analyses of a special class of the Stewart–Gough parallel manipulators whose moving and base platforms are two similar semi-symmetrical hexagons. Employing a unit quaternion to represent the orientation of the moving platform, an analytical expression representing the singularity locus of this class of parallel manipulators in a six-dimensional Cartesian space is obtained. It shows that for a given orientation, the position-singularity locus is a cubic polynomial expression in the moving platform position parameters, and for a given position, the orientation-singularity locus is an analytical expression but not a polynomial directly with respect to the mobile platform orientation parameters. Further inspection shows that for the special class of parallel manipulators, there must exist a nonsingular orientation void in the orientation space around the orientation origin for each position in the position-workspace. Therefore, a new performance index referred to as orientationability is introduced to describe the orientation capability of the special class of manipulators at a given position. A discretization algorithm is proposed for the computation of the orientationability of the special class of manipulators. Moreover, effects of the design parameters and position parameters on the orientationability are investigated in details. Based on the orientationability performance index, another novel performance index referred to as practical orientationability is presented which represents the practical orientation capability of the manipulator at a given position. The practical orientationability not only can satisfy all the kinematic demands and constraints of such class of manipulators, but also can guarantee that the manipulator is nonsingular.     

神华煤燃烧性能及其在火电机组"上大压小"中的作用

在总结神华煤及与其他动力煤配煤特性的基础上,重点分析神华煤与其他动力煤不同掺烧比条件下锅炉运行的经济性能、环保性能及其他性能,突出神华煤在火电机组"上大压小"中的重要作用。     

热电机组DCS硬件分层设计和模块化组态方法

基于美国ABB公司生产的Freelance 800FDCS,提出了硬件分层和软件模块化的设计方案。将热电机组中特性相似的设备作为一类单独设计,简化控制逻辑的组态,以便于控制系统的维护和控制逻辑组态的修改。将该设计方案应用于山东某热电机组的DCS,系统投运后从未出现故障,控制效果良好。     

凝汽采暖两用机组特性刍议

凝汽采暖两用机组目前已得到广泛的应用,为了促进热电联产事业健康发展,本文介绍有关其特性的一些看法,供参考。