Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions

Cyclodextrins (CDs), which are a class of cyclic oligosaccharides extracted from the enzymatic degradation of starch, are often utilized in molecular recognition and assembly constructs, primarily via host–guest interactions in water. In this review, recent progress in CD-based supramolecular nanoassemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented, including pH- and redox-responsive drug and gene delivery, enzyme-activated specific cargo release, photoswitchable morphological interconversion, microtubular aggregation, and cell–cell communication, as well as a geomagnetism-controlled nanosystem for the suppression of tumor invasion and metastasis. Moreover, future perspectives and challenges in the fabrication of intelligent CD-based biofunctional materials are also discussed at the end of this review, which is expected to promote the translational development of these nanomaterials in the biomedical field.     

Supercharged Proteins and Polypeptides

Electrostatic interactions play a vital role in nature. Biomacromolecules such as proteins are orchestrated by electrostatics, among other intermolecular forces, to assemble and organize biochemistry. Natural proteins with a high net charge exist in a folded state or are unstructured and can be an inspiration for scientists to artificially supercharge other protein entities. Recent findings show that supercharging proteins allows for control of their properties such as temperature resistance and catalytic activity. One elegant method to transfer the favorable properties of supercharged proteins to other proteins is the fabrication of fusions. Genetically engineered, supercharged unstructured polypeptides (SUPs) are just one promising fusion tool. SUPs can also be complexed with artificial entities to yield thermotropic and lyotropic liquid crystals and liquids. These architectures represent novel bulk materials that are sensitive to external stimuli. Interestingly, SUPs undergo fluid–fluid phase separation to form coacervates. These coacervates can even be directly generated in living cells or can be combined with dissipative fiber assemblies that induce life-like features. Supercharged proteins and SUPs are developed into exciting classes of materials. Their synthesis, structures, and properties are summarized. Moreover, potential applications are highlighted and challenges are discussed.     

Ergonomics interventions to reduce musculoskeletal risk factors in a truck manufacturing plant

Ergonomic interventions may potentially reduce MSDs, but the context of industries (barriers, ever-changing situations, dialogue processes) might play a significant role in the success of interventions. This study evaluates the effectiveness of ergonomic interventions including engineering/technical and organizational interventions, and the involvement of the stakeholders in reducing musculoskeletal risk factors/symptoms. A pre-post-test experimental study in non-randomized groups was performed over three years in a sector of a truck assembly plant. The mean age of the operators in the sector for the initial and second assessment time was 42.0 (±7.6) years and 39.0 (±8.7), respectively. The mean length of work experience in the current job was 15.2 (±7.2) years and 13.9 (±7.3) for the initial and second assessment times, respectively. Five engineering ergonomic solutions and organizational interventions were implemented after a comprehensive ergonomic analysis. The organizational interventions consisted mostly of transferring and redistributing the tasks, i.e., ergonomically balancing and redesigning of the workstations. Before performing the interventions, the findings of the ergonomic study were presented at several meetings to encourage the involvement of the stakeholders (including managers, engineers, and operators) in the interventions. This study showed that a combination of ergonomic measures—engineering and organizational interventions—could reduce physical workloads. Musculoskeletal symptoms decreased after interventions although the difference was not significant.     

摩擦摆隔震技术研究和应用的回顾与前瞻(Ⅱ)——摩擦摆隔震结构的性能分析及摩擦摆隔震技术的应用

本文回顾了曲面式、沟槽式及曲面沟槽混合式摩擦摆隔震结构的地震反应分析和试验研究进展,评价了各类摩擦摆隔震支座的减震性能,介绍了摩擦摆隔震技术的工程应用,分析了摩擦摆隔震技术研究与应用中存在的问题,提出了今后迫切需要解决的若干问题。     

Multiscale Nanoparticle Assembly: From Particulate Precise Manufacturing to Colloidal Processing

Nanoparticle assembly and colloidal processing are two techniques with the goal to fabricate materials and devices from preformed particles. While colloidal processing has become an integral part of ceramic processing, nanoparticle assembly is still mainly limited to academic interests. It typically starts with the precise synthesis of building blocks, which are generally not only considerably smaller than those used for colloidal processing, but also better defined in terms of size, shape, and size distribution. Their arrangement into 1D, 2D, and 3D architectures is performed with great accuracy well beyond what is achieved by colloidal processing. At the same time, the final assembly is not sintered such that the intrinsic, nanospecific properties of the initial building blocks are preserved or even lead to collective behavior. However, in contrast to colloidal processing the structures accessible by nanoparticle assembly are often limited to a small length scale. The review presents selected examples of nanoparticle assembly and colloidal processing with the goal to reveal the capabilities of these two techniques to fabricate novel materials from preformed building blocks, and also to demonstrate the immense opportunities that would arise if the two methods could be combined with each other.     

Modular product platform configuration and co-planning of assembly lines using assembly and disassembly

Formation of products platforms is carried out during the planning stage and very often separately from the planning of corresponding assembly lines. There is a dearth of literature which considers the different aspects of fully integrating platform design, product family formation, assembly line design, delayed product differentiation, and new concepts of mass customization. A Modular Product Platform Configuration model which uses assembly and disassembly for configuring product variants and Co-Planning of products platforms (MPCC) and their assembly Lines is presented. It is used to co-plan the common platform components and the associated product families simultaneously with the planning of its corresponding mixed-model assembly line. Using both assembly and disassembly to customize the product family platform in order to generate product variants is not commonly discussed in literature. It is defined as the formation of platforms for use to derive multiple products by including many components not shared by every product. The platform is then customized by assembling or disassembling components to form different product variants. The model is formulated using mixed integer mathematical programming to minimize the number of assembly stations and cycle time. Two case studies are used for verification and demonstration. They illustrated the ability of the MPCC model to integrate the planning of product platform, product families and the number of assembly stations required to assemble and disassemble components from mass-assembled product platforms to derive new product variants.     

Two-sided assembly line balancing problem of type I: Improvements,a simple algorithm and a comprehensive study

Many meta-heuristic methods have been applied to solve the two-sided assembly line balancing problem of type I with the objective of minimizing the number of stations, but some of them are very complex or intricate to be extended. In addition, different decoding schemes and different objectives have been proposed, leading to the different performances of these algorithms and unfair comparison. In this paper, two new decoding schemes with reduced search space are developed to balance the workload within a mated-station and reduce sequence-depended idle time. Then, graded objectives are employed to preserve the minor improvements on the solutions. Finally, a simple iterated greedy algorithm is extended for the two-sided assembly line balancing problem and modified NEH-based heuristic is introduced to obtain a high quality initial solution. And an improved local search with referenced permutation and reduced insert operators is developed to accelerate the search process. Computational results on benchmark problems prove the efficiency of the proposed decoding schemes and the new graded objectives. A comprehensive computational comparison among 14 meta-heuristics is carried out to demonstrate the efficiency of the improved iterated greedy algorithm.     

Development of an experimentally validated semi-empirical fully-coupled performance model of a PEM electrolysis cell with a 3-D structured porous transport layer

A semi-empirical non-isothermal model incorporating coupled momentum, heat and mass transport phenomena for predicting the performance of a proton exchange membrane (PEM) water electrolysis cell operating without flow channels is presented. Model input parameters such as electro-kinetics properties and mean pore size of the porous transport layer (PTL) were determined by rotating disc electrode and capillary flow porometry, respectively. This is the first report of a semi-empirical fully coupled model which allows one to quantify and investigate the effect of the gas phase and bubble coverage on PEM cell performance up to very high current densities of about 5 A/cm². The mass transport effects are discussed in terms of the operating conditions, design parameters and the microstructure of the PTL. The results show that, the operating temperature and pressure, and the inlet water flowrate and thickness of the PTL are the critical parameters for mitigating mass transport limitation at high current densities. The model presented here can serve as a tool for further development and scale-up effort in the area of PEM water electrolysis, and provide insight during the design stage.     

华北陆块南缘曲梁煤矿滑动构造及其成因

通过对煤矿滑动构造的研究,目的是进行煤层断开后的正确恢复与对接,从而客观圈定和估算矿体资源量,正确投入矿山开发设计;这首先就要了解滑动构造的组成。曲梁煤矿滑动构造由滑动面、下伏系统和滑体三部分组成。滑动面:呈凹月面形,浅部斜切岩层,深部在二1煤层上下波动,滑动面上下均出现较厚的构造破碎带;下伏系统:主要有奥陶系、石炭及二叠系底部的砂泥岩组成,其层位均在二1煤层下面起着基盘作用;滑体:位于滑动面之上,主要由二叠系二1煤层以上地层组成,为滑动构造的运动部分。滑动构造的运动方向系多次性来回运动,其证据有:在滑动构造范围内全部为地层缺失,构造带既出现糜棱岩、断层泥等压性特征,同时又出现角砾岩的张性特征,先压后张的规律明显。滑动构造的成因系由燕山早期侏罗纪南北向挤压,煤系地层首先形成褶皱构造,大致以二1煤层为界形成滑动构造,整个地质体分割成上下两部分,在重力和地壳挤压的双重作用下,滑体向滑动至最低点后又随惯性滑向对面滑面斜坡,随后又向回滑,这样来回振荡滑动,状似阻尼单摆运动。燕山晚期早白垩世地壳运动由挤压转为伸展,形成高角度正断层切断了滑面的连续性,使二1煤层错断并下降300~600 m,滑动构造终止。这是通过大量钻探资料的总结得出的认识,有助于地质工作者参考该思路寻找构造缺失的煤矿层,使得我们的矿产地质勘查评价更具合理性。     

Robust production planning and control for multi-stage systems with flexible final assembly lines

Production planning of final assembly systems is a challenging task, as the often fluctuating order volumes require flexible solutions. Besides, the calculated plans need to be robust against the process-level disturbances and stochastic nature of some parameters like manual processing times or machine availability. In the paper, a simulation-based optimisation method is proposed that utilises lower level shop floor data to calculate robust production plans for final assembly lines of a flexible, multi-stage production system. In order to minimise the idle times when executing the plans, the capacity control that specifies the proper operator–task assignments is also determined. The analysed multi-stage system is operated with a pull strategy, which means that the production at the final assembly lines generates demands for the preceding stages providing the assembled components. In order to guarantee the feasibility of the plans calculated for the final assembly lines, a decomposition approach is proposed to optimise the production plan of preceding stages. By this way, the robust production can be ensured resulting in reduced losses and overall production costs even though the system is exposed to changes and disturbances.