Role of phosphoproteomics in the development of personalized cancer therapies

Cell signalling pathways driven by protein and lipid kinases contribute to the onset and progression of virtually all cancer types. Consequently, several inhibitors against these enzymes have clinical utility for the treatment of different forms of cancer. A problem that hampers further development is that not all patients respond equally well to kinase inhibitors and a significant proportion of those that initially respond eventually develop resistance. This review considers how an integrative analysis of kinase signalling may be used to address this issue. Advances in the biophysics of mass spectrometry, in biochemical procedures for phosphopeptide enrichment, and in computational approaches for label-free quantification have contributed to the development of phosphoproteomics workflows compatible with the analysis of clinical material. These developments, together with new bioinformatics tools to derive information on signalling circuitry from phosphoproteomics data, allow investigating kinase networks with unprecedented depth. Phosphoproteomics technology is starting to be used in translational research and, with further developments, such methods may also be able to measure the circuitry of cancer signalling networks in routine clinical assays. This review reflects on how this information could be used to accurately predict the best kinase inhibitor for each individual cancer patient.     

计算机视觉在精密模具破损检测系统的应用

在图像准确检测问题的研究中,由于在高精密仪器中,各种损伤极其细微,传统的利用模具高斯曲线拟合检测技术在进行这种破损检测时,往往会因为破损部位过小,造成特征混淆,特征寻优过程陷入不收敛的境地,从而降低了精密模具破损检测的准确性.为了避免上述缺陷,提出了一种边缘像素定位的精密模具破损检测算法.利用像素灰度差值方法,提取精密模具图像的像素特征,并将其作为精密模具破损检测的数据基础.利用一种边缘像素定位方法,计算精密模具破损区域边缘的空间位置,从而实现精密模具的破损检测.实验结果表明,利用改进算法进行精密模具破损检测,能够提高检测的精度,从而满足精密模具生产过程中质量检测的需求.     

A fast tool servo design for precision turning of shafts on conventional CNC lathes

A technique for precision turning of shafts on conventional CNC turning centers is presented. The shaft is semi-turned on a conventional CNC lathe. The precision finish turning operation is delivered by a piezoelectric based fast tool servo which is mounted on the same CNC lathe's turret. The precision tool tip motion is delivered by a proposed sliding mode controller which is robust to changes in the cutting process and hysteresis in the piezo actuator. Sliding mode controller is also quick to compensate the cutting force disturbances, and keeps the tool tip at the desired location within the displacement measurement sensor resolution (±0.1 μm). The fast tool servo system is packaged in a PC, and its effectiveness is demonstrated on a bearing location turning.     

掺BaTiO3对（1-x）NBT—xBaTiO3系陶瓷材料的铁电牲能的影响

采用RadiantPrecisionWorkstation铁电测试系统测试样品的铁电性能，分析BaTiO3的掺人对（1-x）NBT—xBaTiO3系陶瓷材料的铁电性能的影响。实验结果表明：Ba2＋的掺入可有效地降低NBT基陶瓷的剩余极化强度和矫顽场，在准同型相界组成点，矫顽场达到最小值。     

大宗物料激光精密盘库技术开发利用

大宗物料是指大型料场堆放的矿石、煤、球团矿等原料,因其堆积形状复杂、料场巨大等原因很难精确测量其体积。开发大宗物料激光精密盘库技术,总结实际盘库经验,着重对盘库的各项关键技术进行研究和探讨。     

Apparatus for high temperature friction measurement

The static and dynamic coefficient of friction between two flat surfaces at elevated temperature is under investigation. The equipment used in this study was originally designed for the precision glass molding (PGM) process and was then modified for friction measurement. The ultimate aim of this research is to study and characterize the frictional behavior between glass and a mold surface at elevated temperatures typical of the PGM process and under conditions similar to those for this process. This paper describes the design of the apparatus, and validation experiments using a steel-steel material pair at room temperature for comparison with values reported in the literature. The average friction coefficient between the steel-steel pair was found to be 0.17. Subsequent experiments using steel against steel and BK-7 glass against steel, found the stick-slip phenomena is happening at 577 °C.     

Efficient Exact Evaluation of Signs of Determinants

This paper presents a theoretical and experimental study on two different methods to evaluate the sign of a determinant with integer entries. The first one is a method based on the Gram—Schmidt orthogonalization process which has been proposed by Clarkson [Cl]. We review his algorithm and propose a variant of his method, for which we give a complete analysis. The second method is an extension to n × n determinants of the ABDPY method [ABD+2] which works only for 2 × 2 and 3 × 3 determinants. Both methods compute the sign of an n× n determinant whose entries are integers on b bits, by using exact arithmetic on only b +O(n) bits. Furthermore, both methods are adaptive, dealing quickly with easy cases and resorting to full-length computation only for null determinants. Received December 30, 1996; revised September 16, 1998.     

浮动锻造成形技术的发展现状及展望

介绍了浮动锻造加工技术的国内外发展概况与技术展望，阐述了大力发展浮动锻造加工技术的可能性与必要性。     

Equilibrated strategy for population variance estimation

Summary Under the hypothesis that a statistical population can be represented by a density function in a similar way to that of the optimum stratification problem dealt with in Dalenius (1957) and Dalenius and Hodges (1959) the estimation of the population variance is analysed by means of the technique of equilibrated stratification. An unbiased estimator is suggested and it is shown that, with optimum allocation, the precision of the estimator for sufficiently large sample size is always at least that of the classical minimum variance unbiased estimator for a distribution-free setting. A numerical study complete the article.