Influence of self-heating on the millimeter-wave and terahertz performance of MBE grown silicon IMPATT diodes

The influence of self-heating on the millimeter-wave (mm-wave) and terahertz (THz) performance of double-drift region (DDR) impact avalanche transit time (IMPATT) sources based on silicon (Si) has been investigated in this paper. The dependences of static and large-signal parameters on junction temperature are estimated using a non-sinusoidal voltage excited (NSVE) large-signal simulation technique developed by the authors, which is based on the quantum-corrected drift-diffusion (QCDD) model. Linear variations of static parameters and non-linear variations of large-signal parameters with temperature have been observed. Analytical expressions representing the temperature dependences of static and large-signal parameters of the diodes are developed using linear and 2nd degree polynomial curve fitting techniques, which will be highly useful for optimizing the thermal design of the oscillators. Finally, the simulated results are found to be in close agreement with the experimentally measured data.     

Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females—Additive Effect of Postweaning Diet

Maternal obesity increases the risk of health complications in offspring, but whether these effects are exacerbated by offspring exposure to unhealthy diets warrants further investigation. Female Sprague-Dawley rats were fed either standard chow (n = 15) or ‘cafeteria’ (Caf, n = 21) diets across pre-pregnancy, gestation, and lactation. Male and female offspring were weaned onto chow or Caf diet (2–3/sex/litter), forming four groups; behavioural and metabolic parameters were assessed. At weaning, offspring from Caf dams were smaller and lighter, but had more retroperitoneal (RP) fat, with a larger effect in males. Maternal Caf diet significantly increased relative expression of ACACA and Fasn in male and female weanling liver, but not CPT-1, SREBP and PGC1; PPARα was increased in males from Caf dams. Maternal obesity enhanced the impact of postweaning Caf exposure on adult body weight, RP fat, liver mass, and plasma leptin in males but not females. Offspring from Caf dams appeared to exhibit reduced anxiety-like behaviour on the elevated plus maze. Hepatic CPT-1 expression was reduced only in adult males from Caf fed dams. Post weaning Caf diet consumption did not alter liver gene expression in the adult offspring. Maternal obesity exacerbated the obesogenic phenotype produced by postweaning Caf diet in male, but not female offspring. Thus, the impact of maternal obesity on adiposity and liver gene expression appeared more marked in males. Our data underline the sex-specific detrimental effects of maternal obesity on offspring.     

Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling

Fetal stress is known to increase susceptibility to cardiometabolic diseases and hypertension in adult age in a process known as fetal programming. This study investigated the relationship between vascular RAS, oxidative damage and remodeling in fetal programming. Six-month old Sprague-Dawley offspring from mothers that were fed ad libitum (CONTROL) or with 50% intake during the second half of gestation (maternal undernutrition, MUN) were used. qPCR or immunohistochemistry were used to obtain the expression of receptors and enzymes. Plasma levels of carbonyls were measured by spectrophotometry. In mesenteric arteries from MUN rats we detected an upregulation of ACE, ACE2, AT₁ receptors and NADPH oxidase, and lower expression of AT₂, Mas and MrgD receptors compared to CONTROL. Systolic and diastolic blood pressure and plasma levels of carbonyls were higher in MUN than in CONTROL. Vascular morphology evidenced an increased media/lumen ratio and adventitia/lumen ratio, and more connective tissue in MUN compared to CONTROL. In conclusion, fetal undernutrition indices RAS alterations and oxidative damage which may contribute to the remodeling of mesenteric arteries, and increase the risk of adverse cardiovascular events and hypertension.     

凯洛格氨合成系统的分析和物料衡算

应用化工系统分析中的斯图尔特（DVSeward）回路搜索法和自由度分析法对大型氨合成系统（以凯洛格Kellogg流程为例）进行流程分块、再循环回路切割和单元设备计算排序,发现当一定的原始设计变量确定后,分析得计算顺序中的每一个单元设备或选择的体系的物料子问题的自由度均为0或小于0。因此,既可避免复杂繁琐的物热联解和全系统的迭代收敛,又可应用序贯模块法进行物料平衡的计算机模拟,使计算快速准确。     

基于ATR技术的有机聚合物二次电光系数的测量

二次电光效应是有机聚合物材料一种重要的电光特性,利用这种特性可以制备有机聚合物电光调制器等电光器件.有机聚合物材料的二次电光系数是衡量其二次电光效应的一个重要参数,其可以用一个6×6阶的张量来表示.利用该张量的对称特性、各个元素之间的已知关系以及折射率椭球公式,本文提出了一种基于衰减全反射(ATR)技术的测量有机聚合物二次电光系数的方法.在测量中,通过选用TM偏振光以及TE偏振光作为测量光束,可以分别获得二次电光系数张量中S11以及S12元素.利用已知关系,可以计算得到S44以及直流克尔系数.从而得到二电光系数张量中所有元素的值.     

逆向工程中测量数据点的滤波

针对用于曲面拟合的逆向工程散乱数据点云,提出一种先加权中值滤波,再小波包分析滤波的新滤波方法。为避免繁琐的编程,充分利用M atlab中的小波包滤波函数,提出VC 与M atlab混合编程编制数值计算程序的方法,并用实际计算结果验证了该方法的可行性。     

Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response,Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inflammation and accelerated aging, we test the hypothesis whether maternal obesity induces aging processes in the developing liver and determines thereby hepatic growth. To this end, maternal obesity was induced with high-fat diet (HFD) in C57BL/6N mice and male offspring were studied at the end of the lactation [postnatal day 21 (P21)]. Maternal obesity induced an obese body composition with metabolic inflammation and a marked hepatic growth restriction in the male offspring at P21. Proteomic and molecular analyses revealed three interrelated mechanisms that might account for the impaired hepatic growth pattern, indicating prematurely induced aging processes: (1) Increased DNA damage response (γH2AX), (2) significant upregulation of hepatocellular senescence markers (Cdnk1a, Cdkn2a); and (3) inhibition of hepatic insulin/insulin-like growth factor (IGF)-1-AKT-p38-FoxO1 signaling with an insufficient proliferative growth response. In conclusion, our murine data demonstrate that perinatal obesity induces an obese body composition in male offspring with hepatic growth restriction through a possible premature hepatic aging that is indicated by a pathologic sequence of inflammation, DNA damage, senescence, and signs of a possibly insufficient regenerative capacity.     

露天矿生产车辆安排计划优化设计

本文结合露天矿车辆生产安排计划的特点,全面分析了车辆安排问题约束条件,构建了基于整数规划的线路车次安排数学模型。利用线性规划对电铲进行初始布点,实现对模型的合理简化,加速模型的求解。考虑到电铲利用率很难达到1,为提高模型最优解的实际应用的可行性,增加了车辆调度的弹性,设置了电铲的最大利用率。为保证电铲有一定的利用率,设置了电铲最小利用率。计算表明本模型具有较好的实用性和通用性。     

用MasterCAM加工双金属材料链轮硬齿表面

运用MasterCAM软件对双金属材料链轮硬齿表面进行曲面三维造型,编程,并对链轮双金属材料硬齿表面进行曲面合理工艺设计,加工出了符合图纸要求的产品零件。阐述了MasterCAM软件在加工实例产品时编程的基本步骤,重点突出了其加工工艺和加工参数等关键问题。