Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus

2,4-Thiazolidinedione (TZD) is a privileged and highly utilised scaffold for the development of pharmaceutically active compounds. This sulfur-containing heterocycle is a versatile pharmacophore that confers a diverse range of pharmacological activities. TZD has been shown to exhibit biological action towards a vast range of targets interesting to medicinal chemists. In this review, we attempt to provide insight into both the historical conventional and the use of novel methodologies to synthesise the TZD core framework. Further to this, synthetic procedures utilised to substitute the TZD molecule at the activated methylene C₅ and N₃ position are reviewed. Finally, research into developing clinical agents, which act as modulators of peroxisome proliferator-activated receptors gamma (PPARγ), protein tyrosine phosphatase 1B (PTP1B) and aldose reductase 2 (ALR2), are discussed. These are the three most targeted receptors for the treatment of diabetes mellitus (DM).     

Self-healing property of epoxy/nanoclay nanocomposite using poly(ethylene-co-methacrylic acid) agent

This paper investigates the self-healing repair of cracks in an epoxy/nanoclay nanocomposite using mendable poly[ethylene-co-methacrylic acid] (EMAA) particles. The effects of two different concentrations of EMAA agent on the self-healing efficiency were measured using single edge notch bar (SENB) testing. Inclusion of EMAA particles into the nanocomposite results an increase in the fracture strength and strain of the SENB specimens. Damaged SENBs were healed at 150 °C for 30 min to achieve up to 63% recovery in critical stress intensity and over 85% recovery in sustainable peak load. Also, X-ray diffraction (XRD) analysis and tensile test used in order to examine the nanocomposite structure and investigate the effects of EMAA inclusion on the nanocomposite mechanical properties. The pressure delivery mechanism of the healing agent is shown by scanning electron microscopy (SEM) images. It seems EMAA can be used as an effective self-healing agent for epoxy/nanoclay nanocomposites.     

Evaluation of gluing of CFRP onto concrete structures by infrared thermography coupled with thermal impedance

Carbon Fiber Reinforced Polymers (CFRPs) have been increasingly employed for structural strengthening, and are attached to structures using bonding adhesives. The aim of this work is to characterize defects in the bond between CFRP and concrete (after they are located by pulse infrared thermography), and assign the defects a “numerical value” (ranging from 0 for a complete air–gap to 1 for a fully glued bond). Quantitative characterization is performed by measuring the thermal impedance, and then identifying the thermophysical parameters of the system through fitting the measured impedance to a theoretical model. An inversion procedure is carried out to estimate the unknown parameters, without prior knowledge of sample properties. In particular, it is possible to estimate more accurately both the amount of glue within a defect and the thermal contact resistance.     

Distinct dispersion stability of various TiO2 nanopowders using ammonium polyacrylate as dispersant

The dispersion stabilities of three titania (TiO₂) nanopowders with different particle sizes and surface chemistries in aqueous suspensions containing a common water-based dispersant, ammonium polyacrylate (PAA-NH₄), have been investigated and compared. According to adsorption isotherm and Fourier transform infrared spectroscopy analyses, the adsorption conformations of PAA-NH₄ are distinct for the different TiO₂ nanopowders. In addition, PAA-NH₄ exhibited the greatest adsorption affinity to the larger, hydrophilic TiO₂ nanopowder and the least affinity to smaller, hydrophobic nanopowder. From sedimentation and rheological results, the dispersion stability of the larger, hydrophilic TiO₂ nanopowder was demonstrated to be the greatest. Based on thermodynamic and kinetic calculations for the stabilization energies, the larger, hydrophilic TiO₂ nanopowder was also shown to be the best-stabilized powder, although it settles faster than the smaller, hydrophilic TiO₂ nanopowder; this is due to the greater affection of sedimentation flux on the larger nanopowder. In contrast, the hydrophobic TiO₂ nanopowder formed a gel-like structure in the aqueous suspension when the solid content was greater than 10 wt%, which is attributed to polymer bridging between PAA-NH₄-adsorbed TiO₂ nanoparticles.     

On the design and optimization of hybrid carbon fiber reinforced polymer-steel cable system for cable-stayed bridges

This paper addresses the effective use of carbon fiber reinforced polymeric (CFRP) materials in the cable system. As the span length of cable-stayed bridges increases, several technical challenges become more dominant with traditional material. This paper mainly focuses on improving the aerodynamic performance through implementing CFRP composites in the cable system in combination with steel. In order to maximize the improvement, a genetic algorithm (GA)-based optimization procedure is developed to optimize the distribution of CFRP and steel. A numerical example is presented and the results suggest the typical composition of an optimized CFRP-steel cable system for long-span cable-stayed bridges.     

Exact solution for free vibration of coupled double viscoelastic graphene sheets by viscoPasternak medium

Based on nonlocal theory, this article discusses vibration of CDVGS¹ systems. The properties of each single layer graphene sheet (SLGS) are assumed to be orthotropic and viscoelastic. The two SLGSs are simply supported and coupled by an enclosing viscoelastic medium which is simulated as a Visco-Pasternak layer. This model is aimed at representing dynamic interactions in nanocomposite materials with dissipation effect. By considering the Kirchhoff plate theory and Kelvin–Voigt model, the governing equation is derived using Hamilton's principle. The equation is solved analytically to obtain the complex natural frequency. The parametric study is thoroughly performed, concentrating on the series effects of viscoelastic damping structure, aspect ratio, visco-Pasternak medium, and mode number. In this system, in-phase (IPV) and out-of-phase (OPV) vibrations are investigated. The numerical results of this article show a perfect correspondence with those of the previous researches.     

Micromechanical modeling and experimental characterization on viscoelastic behavior of 1–3 active composites

A study on the temperature-dependent viscoelastic behavior of (1–3 active composites) 1–3 piezocomposites and bulk piezoceramic subjected to electromechanical loading is carried out. The temperature-dependent effective properties are obtained experimentally using resonance based measurement technique. Experiments are also preformed for various fiber volume fractions of 1–3 piezocomposites subjected to constant compressive prestress and cyclic electric field at elevated temperature to understand the time-dependent behavior. Based on the measurements it is observed that the viscoelastic behavior has a significant influence on the electromechanical responses of 1–3 piezocomposites. Hence a viscoelastic based numerical model (unit cell approach) is proposed to predict the time-dependent effective properties of 1–3 piezocomposites. The evaluated effective properties are incorporated in a finite element based 3-D micromechanical model to predict the time-dependent thermo-electro-mechanical behavior of 1–3 piezocomposites and compared with the experimental observations.     

Experimental and numerical investigation of composite bolted π-joint subjected to bending load

This present work investigated the failure mechanism of a novel composite bolted π-joint subjected to bending load by experimental and finite element simulation. A test sample manufactured by resin transfer moulding process (RTM) was tested. A 3D progressive damage model developed in ABAQUS/Standard was used to simulate the failure of the π-joint. Based on good correlation of failure load and damage distribution between experimental results and FE prediction, further investigation was extended to the effect of two primary assembly clearances on mechanical behavior of the π-joint. The study results reveal that delamination of the fillet region in L-preform is the π-joint's failure mode. Moreover, the assembly clearances have little effect on the failure load of the joint.     

In-situ damage sensing of woven composites using carbon nanotube conductive networks

We report an in situ analysis of the microstructure of woven composites using carbon nanotube (CNT)-based conductive networks. Two types of specimens with stacking sequences of (0/90)_s (on-axis) and (22/85/−85/−22) (off-axis) were manufactured using ultra-high-molecular-weight polyethylene fibers and a CNT-dispersed epoxy matrix via vacuum-assisted resin transfer molding. The changes in the electrical resistance of the woven composites in response to uniaxial loading corresponded to the changes in the gradient of the stress–strain curves, which is indicative of the initiation and accumulation of microscopic cracking and delamination. The electrical resistance of the woven composites increased due to both elongation and microscopic damage; interestingly, however, it decreased beyond a certain strain level. In situ X-ray computed tomography and biaxial loading tests reveal that this transition is due to yarn compaction and Poisson’s contraction, which are manifest in textile composites.     

Micromechanical modeling of the progressive failure in short glass–fiber reinforced thermoplastics – First Pseudo-Grain Damage model

This paper presents a new micromechanical damage model, called “First Pseudo-Grain Damage” (FPGD) model, to predict the overall elasto-plastic behavior and damage evolution in short fiber reinforced thermoplastic materials typically produced by injection molding. The model combines mean-field homogenization theory with a continuum damage model, leading to a semi-analytical estimate of the composite incremental response that is convenient for the large scale simulation of composite structures. Each representative volume element (RVE) of the composite is decomposed into a set of pseudo-grains (PGs), which are two-phase composites with aligned fibers of the same aspect ratio. The PGs are homogenized individually according to a nonlinear Mori–Tanaka scheme. Then, a self-consistent scheme is applied to the aggregate of homogenized PGs. An anisotropic damage model is used at the PG level which enables accommodating arbitrary multiaxial and non-monotonic loading histories. Damage evolution inside PGs progressively affects the overall stiffness and strength of the RVE up to total failure. An evaluation of the proposed model against experimental data is conducted for short glass–fiber reinforced polyamide 6,6 (PA6,6). It is shown that the model yields satisfactory predictions of the response under uniaxial tension on samples with different fiber contents and under various loading directions relative to the main injection flow direction.