Investigation of the stability of tablets prepared from sucrose and citric acid anhydride utilizing response surface methodology

Inversion of sucrose is a stability problem particularly of candies with acidic taste that contain sucrose and small amounts of organic acids such as citric acid, since the free d-fructose produced by hydrolysis is hygroscopic. The following possibilities were investigated for preventing the hydrolysis of sucrose in tablets containing sucrose and citric acid: Adding various amounts of tri-sodium citrate to the formulation to neutralize the citric acid, (Hot) melt coating of citric acid and tri-sodium citrate with a vegetable fat at different coating ratios, variation of the ratio of coated citric acid and tri-sodium citrate in formulations, and compressing the formulations with different compression forces. After tablet processing and storage of tablets, the concentration of d-fructose was determined on the basis of enzymatic reactions. A response surface central composite design was used. The above-mentioned variations were chosen as independent variables and the amount of d-fructose was chosen as response variable. The lowest rates of inversion could be achieved by increasing the content of tri-sodium citrate and the ratio of coating material and decreasing the ratio of coated citric acid and tri-sodium citrate in the tablet formulations. The compression force had no significant effect on the inversion of sucrose.     

用面向对象编程实现问题求解自动化

本文从面向对象方法基本原理和面向对象编程的技术特征出发，阐明所建应用软件系统中的对象，类及相应类层次结构和类组合结构，使系统具有很强的表现真空世界复杂系统结构的能力，系统通过消息传递在程序执行中实现对操作的调用机制，使之在面向用户问题选择和执行求解策略方面有很强的适应性，这一点对于强调人－机交互和解题协作的智能决策支持系统设计至关重要，文章给出了用Ｃ＋＋实现的模型对象系统及消息传递机制。     

Supporting collaborative engineering design

The complexity of current engineering design demands the collaboration of specialists. Collaboration involves both communication between and coordination among members of a design team. Currently, design collaboration is carried out through the use of schedules, specifications and drawings which only capture the end results of the design process. They fail to record important design information such as the reasoning behind design decisions. In this paper, we describe a tool CADS, that supports collaboration in engineering design. CADS is based on an extension to the Axiomatic Design methodology which not only captures the design elements but also the rationale used to conceive them. CADS serves as a shared database of design information with facilities that support communication and coordination in engineering design.Currently at the Media Laboratory, MIT.     

e-LITE： A Concurrent Engineering Method Dedicated to E-learning Training Development for the Enhancement of Research Project Results

Scientific research projects aim to produce new knowledge generally in domains of high specialization.Some of these projects have goals of improving the performance of companies.In this case,the issues of the capitalization and transfer of scientific knowledge and its rapid transformation into professional skills are directly addressed.However,there is no method to derive e-learning teaching material from project results.So,this paper presents the e-LITE Method and its application to the ISTA3 project to support the process of developing a e-learning training.This application has allowed us to highlight the contributions of the method that promotes better knowledge sharing between partners of a research project and the development and transfer of research results to the professional world.So,after the presentation of the method,an application to the ISTA3 project will be presented.     

On the fit of models to covariances and methodology to the Bulletin..

Notes that 7 of the 10 top-cited articles in the Psychological Bulletin deal with methodological topics. One of these is the P. M. Bentler and D. G. Bonett (1980) article on the assessment of fit in covariance structure models. Some context is provided on the popularity of this article. In addition, a citation study of methodology articles appearing in the Bulletin since 1978 was carried out. It verified that publications in design, evaluation, measurement, and statistics continue to be important to psychological research. Some thoughts are offered on the role of the journal in making developments in these areas more accessible to psychologists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Universal Method of Scientific Inquiry

A paradigm of scientific discovery is defined within a first-order logical framework. Within this paradigm, the concept of successful scientific inquiry is formalized and investigated. Among other results, it is shown that a simple method of scientific inquiry is universal in the sense that it leads to success on every problem for which success is in principle possible.     

低锰高铁矿直接还原-熔分制备富锰渣试验研究

摘要：试验以锰品位27.7%,铁品位18.1%的低锰高铁矿为研究对象还原制备富锰渣,生产得到的富锰渣可用于冶炼硅锰合金,以达到高效利用低品位锰矿的目的。根据该矿的成分分析、XRD分析和粒度检测分析结果,采用还原 熔分法对低锰矿进行还原制备富锰渣试验,试验结果表明：单因素试验下各参数对低锰高铁矿的还原-熔分后渣中Mn、Fe元素的含量和Mn元素的回收率均有较大影响,同时结合Box-Behnke原理设计方案,选取温度、碱度以及配碳量3个试验因素,通过响应曲面法研究各因素交互作用下对Mn元素回收率的影响规律,对试验因素进行优化分析,建立相应的多项式模型。模拟优化得到最优的工艺条件为：还原温度1402℃,碱度0.10,配碳量10.04%,Mn元素回收率为97%。在最佳条件下做验证试验得出Mn元素回收率为95.80%,误差1.24%,证明响应曲面法预测模型具有可靠性,同时对低锰高铁矿的应用有重要指导意义。     

碳酰胺助浸风化壳淋积型稀土矿工艺研究

研究了以碳酰胺为助浸剂的风化壳淋积型稀土矿浸取稀土工艺。通过柱浸方式模拟原地浸出过程,在单因素试验基础上,采用响应曲面法建立二次多项数学模型,以稀土浸取率为响应值,探究助浸剂碳酰胺浓度、浸取温度和浸取剂溶液pH对稀土浸取率的影响,分析各因素间的交互作用。结果表明,影响稀土浸取率从强到弱的因素依次是浸取剂溶液pH、碳酰胺浓度、浸取温度。在浸取剂乙酸铵浓度0.10 mol/L条件下,最佳工艺参数为碳酰胺浓度0.59 mol/L、浸取温度25.03 ℃、浸取剂pH=5.51,该条件下稀土浸取率响应值为97.50%。实际试验稀土浸取率为96.36%。两者误差较小,表明采用响应曲面模型得到的工艺参数是基本可靠的。     

等效梁法及其在柔性铰链机构中的应用

文章讨论了等效梁法的基本原理，然后以双平行四杆柔性铰链机构为例分析其位移性能；采用该方法进行有限元建模，一个柔性铰链由4个梁单元组成，因而，整个柔性铰链机构的单元数很少。分析结果表明：等效梁法仿真效率高，且有很高的精度。这一点对于仿真分析复杂的柔性铰链机构非常重要。