以乙酰辅酶A羧化酶(Accase)为靶标的抗菌剂研究进展

综述了同内外以乙酰辅酶A羧化酶Accase为靶标的抗菌剂研究进展及存在的问题,并简要介绍了笔者课题组的相关研究工作。     

Influence of curcuma (Curcuma xanthorrhiza Roxb) on lipid metabolism in rabbits

The efficacy of curcuma (Curcuma xanthorrhiza) in lowering blood plasma lipid was evaluated in rabbits. Forty male New Zealand white rabbits (2.3 kg) were divided into four equal groups and offered isoatherogenic diets with no curcuma, low curcuma (2 g kg^?1), medium curcuma (3 g kg^?1) and high curcuma (4 g kg^?1) for 120 days. Faeces and feed samples were collected. Body weight was measured weekly. Blood samples at 1, 2 and 4 months and liver samples at the last blood collection were taken. Curcuma did not influence feed, protein and fat consumption and protein excretion (P > 0.05) but significantly (P < 0.05) increased fat excretion. Cholesterol concentration was decreased by 46.6, 56.4 and 63.2% and HDL concentration was decreased by 9.9, 14.5 and 21.9% at 2, 3 and 4 g kg^?1 curcuma respectively. Curcuma significantly (P < 0.05) decreased LDL concentration and significantly (P < 0.01) decreased triglyceride concentration by 20.4, 28.5 and 29.5% at 2, 3 and 4 g kg^?1 respectively. HMG‐CoA reductase inhibitor was significantly (P < 0.05) increased by curcuma. Glucose was significantly (P < 0.05) reduced by 6.2, 7.6 and 18.0% at 2, 3 and 4 g kg^?1 curcuma respectively. Lipid peroxidation was prevented at 3 and 4 g kg^?1 curcuma. The enhanced fat excretion could have been mediated through an acceleration of lipid metabolism from extrahepatic tissues to the liver, which would increase the excretion of cholesterol via the bile and into the faeces. Since this is central to lipid metabolism, curcuma has potential as a phytotherapeutic agent under atherosclerosis and cardiovascular disease conditions. © 2002 Society of Chemical Industry     

城市光网动态提速技术研究及应用——上海“城市光网”技术创新和应用实践之四

通过对城市光网中的新兴业务——动态提速业务的两种技术实现原理的分析,提出了技术选择的原则,并就相关系统改造的实现流程和技术方案进行了详尽的阐述。同时,本文针对未来技术的发展,提出了城市光网动态提速业务未来的新业务模型和演进技术。     

Full disclosure data on clinical psychology doctorate programs.

The purposes of this article was to examine the rates at which Council of University Directors of Clinical Psychology (CUDCP) doctoral programs provided full disclosure information on their respective Web sites. Additionally, consistency of full disclosure data was examined using internship match rates, and summary statistics are provided for a normative basis. Of 153 programs, at least some data were located for 111 programs. Large discrepancies were found when comparing internship match statistics reported by programs with match statistics listed by Association of Psychology Postdoctoral and Internship Centers (APPIC). The mean profile of a CUDCP program includes about 160 applicants per year, of which the program admits eight new graduate students. These eight new graduate students have a GRE verbal score of 590, a quantitative GRE score of 650, an undergraduate GPA of 3.63, and take 6.5 years to complete their doctoral degree (including internship). These programs reported an average match rate of 93%. Given the Committee on Accreditation's (CoA's) new mandate for reporting program disclosure variables, the article concludes with recommendations for how best to report these data. (PsycINFO Database Record (c) 2010 APA, all rights reserved)