台阶轴拐角R的感应淬火

针对台阶轴拐角R处难以实现感应淬火的问题,设计了一种特殊的双室水路连续淬火感应器.将感应器冷却水与淬火液完全分开控制的工艺方案,较好地解决了拐角R处的中频深层淬火问题.R处的淬硬层深度可达2.5 mm以上,大大提高了产品零件的断裂强度.     

汽车空调制冷剂与大气臭氧层保护的研究

氯氟烃类化合物(CFCs)对大气臭氧层有着严重的破坏作用,危及人类的生存安全.为了保护大气臭氧层、使人类生态环境可持续发展,对汽车空调系统中使用的CFCs必须加以限制和禁用,为此应采取切实可行的措施.现就CFCs与大气臭氧层的关系及危害机理作了分析,并针对CFCs类中的典型常见制冷剂R12进行分析,结合实践,对汽车空调应采取的对策作了简要阐述.     

不对称合成(R)-2-羟基-4-苯基丁酸乙酯的动力学

采用10,11-二氢辛可尼定修饰的Pt/Al2O3催化体系,不对称加氢合成(R)-2-羟基-4-苯基丁酸乙酯,研究了各因素影响反应速率和光学收率的一般规律.根据推测的机理,建立了未修饰体系中加氢反应的本征动力学模型,结合实验数据选定了较佳的模型.假设不对称加氢反应总速率包括反应物在催化剂表面修饰位上和未修饰位上两部分的加氢速率,建立了不对称加氢的动力学模型,经拟合得到参数并进行了验证和讨论.     

关于衡器国际技术法规产品选择试验的规定

本文主要是阐述衡器国际技术法规R最新草案中“系列”方面的内容,该最新草案比过去的版本变更的地方不少,增加了许多新内容,希望我国衡器研发与产品标准、技术法规制定者积极的研究采纳。     

淀川杜鹃扦插繁殖技术的初步研究

淀川杜鹃(R.yedoehse)观赏价值较高,且具有极强的抗寒性,能耐-27℃的低温,但用常规方法繁殖很难成功。半木质化插穗经2℃低温处理18 d,结合1 250 ppm吲萘粉剂溶液浸蘸5 m in,插穗生根率可达95%。基本解决了淀川杜鹃的繁殖技术问题,具有推广价值。     

Evaluation of the performance of metameric indices

Forty three metameric pairs were obtained by comparison, shade-adjustment, and redyeing of 660 self shades dyed with direct, azoic, vat, and reactive dyes. The pairs were regrouped shadewise and ranked visually in increasing order of metamerism. Spearman's rank correlation coefficients were calculated between 11 measures of metamerism and the visual metameric ranking under three illuminants A, D65, and TL84 in pairs. The illuminant-independent general indices included the indices based on reflectance differences (Bridgeman), weighted reflectance differences (Nimeroff and Yurow), Cohen-Kappauf's residual differences (proposed) obtained from the spectral decompositions of the reflectance spectra of the metameric pair. Illuminant-specific special indices included color-differences under test illuminant, addition, subtraction, division, and multiplication of color-differences under test and reference illuminants, indices based on ΔL*, Δa*, Δb* differences under two illuminants, based on chromatic adapted ΔL*, Δa*, Δb* differences with multiplicative corrections for tristimulus differences under reference illuminant (Berns-Billmeyer), differences of the color constancy indices. The present work showed that indices based on ΔL*, Δa*, Δb* differences under two illuminants, both unmodified and modified by Berns-Billmeyer performed best among the existing indices. The differences of color constancy indices showed good correlation with the degree of metamerism in some cases, and this may be utilized for developing newer indices of metamerism. © 1996 John Wiley & Sons, Inc.     

HSDPA的引入策略

首先简述HSDPA承载业务的定位．然后重点从引入方式、组网方式、码资源和功率资源的分配策略等方面分析了HSDPA的引入策略。     

高产人参发根系的建立及发根中皂苷Rb1的分离纯化

利用发根农杆菌A4菌株在2年生人参根外植体上直接诱导产生人参发根。对16个人参发根系比生长速率及人参总皂苷含量进行测定,得到3个具有较高比生长速率和人参皂苷含量的发根系。其中发根系R9923具有最高的比生长速率,在连续培养4周后生长量比最初提高了28.8倍。研究R9923发根系的生长曲线和皂苷含量变化规律发现,随着发根生物量的增加,发根中皂苷含量积累得也越多。利用HPLC法测定了R9923发根系中单体皂苷Rg1、Re、Rb1的含量。生长4周的人参发根总皂苷含量达15.2 mg/g,其中人参皂苷Rb1的含量为68.3%,比3年生栽培人参中Rb1含量高1.3倍,可以用于大规模培养。用硅胶柱层析法从人参发根总皂苷中分离提纯人参皂苷Rb1,当洗脱剂中氯仿∶甲醇=7.5∶2.5(体积比)时洗脱效果较好。用硅胶柱法提取的皂苷Rb1纯度为89.95%,得率为72.7%。     

Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma

The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. The lymph nodes of patients with malignant lymphomas have shown to contain high levels of histamine, however, less is known regarding the expression and function of the H4R in T-cell lymphoma (TCL). In this work we demonstrate the expression of H4R isoforms (mRNA and protein) in three human aggressive TCL (OCI-Ly12, Karpas 299, and HuT78). Histamine and specific H4R agonists (VUF8430 and JNJ28610244) significantly reduced cell viability in a dose-dependent manner (p < 0.05). The combined treatment with the H4R antagonist (JNJ7777120, 10 µM) reversed the effects of the H4R ligands. Importantly, we screened a drug repurposing library of 433 FDA-approved compounds (1 μM) in combination with histamine (10 μM) in Hut78 cells. Histamine produced a favorable antitumor effect with 18 of these compounds, including the histone deacetylase inhibitor panobinostat. Apoptosis, proliferation, and oxidative stress studies confirmed the antitumoral effects of the combination. We conclude that the H4R is expressed in TCL, and it is involved in histamine-mediated responses.