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排序方式: 共有120条查询结果,搜索用时 15 毫秒
111.
水平连铸变频伺服控制系统 总被引:2,自引:0,他引:2
介绍了变频伺服控制系统的组成、SIMODRIVE变频系统功能及特点以及在水平连铸机上的应用 ,实践表明利用变频伺服控制设计或改造的控制系统具有良好的动态性能和较高的控制精度。 相似文献
112.
介绍了采用水平连铸坯生产27SiMn钢液压支柱管的设备、生产工艺及轧制结果。分析了过去所生产的27SiMn钢液压支柱管合格率低的原因,指出了采用水平连铸坯生产27SiMn钢液压支柱管成功的关键。 相似文献
113.
论无缝钢管生产的当代水平:兼论全浮动芯棒连轧管厂的技术改造 总被引:1,自引:0,他引:1
通过剖析90年代投产的无缝钢管厂提出了当代无缝钢管生产的两个重要方面:采用先进的轧管工艺和高水平的工艺过程自动控制。在此基础上,对全浮动芯棒连轧管厂的技术改造提出了一些看法。 相似文献
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115.
Sonja M. Kessler Yvette Simon Katja Gemperlein Kathrin Gianmoena Cristina Cadenas Vincent Zimmer Juliane Pokorny Ahmad Barghash Volkhard Helms Nico van Rooijen Rainer M. Bohle Frank Lammert Jan G. Hengstler Rolf Mueller Johannes Haybaeck Alexandra K. Kiemer 《International journal of molecular sciences》2014,15(4):5762-5773
Non-alcoholic steatohepatitis (NASH) represents a risk factor for the development of hepatocellular carcinoma (HCC) and is characterized by quantitative and qualitative changes in hepatic lipids. Since elongation of fatty acids from C16 to C18 has recently been reported to promote both hepatic lipid accumulation and inflammation we aimed to investigate whether a frequently used mouse NASH model reflects this clinically relevant feature and whether C16 to C18 elongation can be observed in HCC development. Feeding mice a methionine and choline deficient diet to model NASH not only increased total hepatic fatty acids and cholesterol, but also distinctly elevated the C18/C16 ratio, which was not changed in a model of simple steatosis (ob/ob mice). Depletion of Kupffer cells abrogated both quantitative and qualitative methionine-and-choline deficient (MCD)-induced alterations in hepatic lipids. Interestingly, mimicking inflammatory events in early hepatocarcinogenesis by diethylnitrosamine-induced carcinogenesis (48 h) increased hepatic lipids and the C18/C16 ratio. Analyses of human liver samples from patients with NASH or NASH-related HCC showed an elevated expression of the elongase ELOVL6, which is responsible for the elongation of C16 fatty acids. Taken together, our findings suggest a detrimental role of an altered fatty acid pattern in the progression of NASH-related liver disease. 相似文献
116.
根据成都无缝钢管厂水平连铸的生产实践,建立了较大断面铸坯凝固传热过程数学模型。通过数学模拟仿真,找出铸坯在结晶器和喷水区内凝固传热过程的温度场变化,凝壳生长规律及液芯长度等与浇注参数(拉速,浇注温度)的关系。 相似文献
117.
Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress from the mildest form of simple steatosis to nonalcoholic steatohepatitis (NASH) that increases the risk for hepatocellular carcinoma (HCC), which is a malignancy with a dismal prognosis and rising incidence in the United States and other developed counties, possibly due to the epidemic of NAFLD. Metformin, the first-line drug for T2DM, has been suggested to reduce risks for several types of cancers including HCC and protect against NASH-related HCC, as revealed by epidemical studies on humans and preclinical studies on animal models. This review focuses on the pathogenesis of NASH-related HCC and the mechanisms by which metformin inhibits the initiation and progression of NASH-related HCC. Since the functional role of immune cells in liver homeostasis and pathogenesis is increasingly appreciated in developing anti-cancer therapies on liver malignancies, we discuss both the traditional targets of metformin in hepatocytes and the recently defined effects of metformin on immune cells. 相似文献
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119.
Chen-Lin Yu Meng-Shih Weng Wei-Cheng Chen Kai-Ting Chien Chih-Wen Chi Ching-Hu Chung Chia-Wen Huang Po-Chuan Wang Chien-Chih Chen An-Chi Tsai Shih-Chia Liu Shih-Wei Wang 《International journal of molecular sciences》2021,22(6)
Hepatocellular carcinoma (HCC) frequently shows early invasion into blood vessels as well as intrahepatic metastasis. Innovations of novel small-molecule agents to block HCC invasion and subsequent metastasis are urgently needed. Moscatilin is a bibenzyl derivative extracted from the stems of a traditional Chinese medicine, orchid Dendrobium loddigesii. Although moscatilin has been reported to suppress tumor angiogenesis and growth, the anti-metastatic property of moscatilin has not been elucidated. The present results revealed that moscatilin inhibited metastatic behavior of HCC cells without cytotoxic fashion in highly invasive human HCC cell lines. Furthermore, moscatilin significantly suppressed the activity of urokinase plasminogen activator (uPA), but not matrix metalloproteinase (MMP)-2 and MMP-9. Interestingly, moscatilin-suppressed uPA activity was through down-regulation the protein level of uPA, and did not impair the uPA receptor and uPA inhibitory molecule (PAI-1) expressions. Meanwhile, the mRNA expression of uPA was inhibited via moscatilin in a concentration-dependent manner. In addition, the expression of phosphorylated Akt, rather than ERK1/2, was inhibited by moscatilin treatment. The expression of phosphor-IκBα, and -p65, as well as κB-luciferase activity were also repressed after moscatilin treatment. Transfection of constitutively active Akt (Myr-Akt) obviously restored the moscatilin-inhibited the activation of NF-κB and uPA, and cancer invasion in HCC cells. Taken together, these results suggest that moscatilin impedes HCC invasion and uPA expression through the Akt/NF-κB signaling pathway. Moscatilin might serve as a potential anti-metastatic agent against the disease progression of human HCC. 相似文献
120.
针对部分家用电器使用时需要限时,设计了一种可以任意设置用电时间的数显式定时控制器,可以消除因遗忘而未及时关断电源所造成的隐患。控制器比普通插座略大,可以直接插入到普通插座,不必改动原来电路。因此使用非常方便,有较大的应用前景。 相似文献