成像卫星星地联合成像调度

成像卫星星地联合调度问题,涉及调度对象众多,约束条件复杂,需要考虑任务的观测、回传2个过程,是一个具有两层时间窗口约束的双层优化问题,统一建模困难。根据问题的特点,采用基于阶段优化的方式,降低了问题的复杂性。把问题分为观测调度阶段和数据回传调度阶段,分别给出了优化目标和约束条件,建立了基于阶段优化的成像卫星星地联合调度模型,实现了从任务观测到数据回传的全过程调度。仿真实例表明,该方法能够有效解决多星多站的协同任务调度问题。     

Novel (Phenothiazinyl)Vinyl-Pyridinium Dyes and Their Potential Applications as Cellular Staining Agents

We report here the synthesis and structural characterization of novel cationic (phenothiazinyl)vinyl-pyridinium (PVP) dyes, together with optical (absorption/emission) properties and their potential applicability as fluorescent labels. Convective heating, ultrasound irradiation and mechanochemical synthesis were considered as alternative synthetic methodologies proficient for overcoming drawbacks such as long reaction time, nonsatisfactory yields or solvent requirements in the synthesis of novel dye (E)-1-(3-chloropropyl)-4-(2-(10-methyl-10H-phenothiazin-3-yl)vinyl)pyridin-1-ium bromide 3d and its N-alkyl-2-methylpyridinium precursor 1c. The trans geometry of the newly synthesized (E)-4-(2-(7-bromo-10-ethyl-10H-phenothiazin-3-yl)vinyl)-1-methylpyridin-1-ium iodide 3b and (E)-1-methyl-4-(2-(10-methyl-10H-phenothiazin-3-yl)vinyl)pyridin-1-ium tetrafluoroborate 3a′ was confirmed by single crystal X-ray diffraction. A negative solvatochromism of the dyes in polar solvents was highlighted by UV-Vis spectroscopy and explanatory insights were supported by molecular modeling which suggested a better stabilization of the lowest unoccupied molecular orbitals (LUMO). The photostability of the dye 3b was investigated by irradiation at 365 nm in different solvents, while the steady-state and time-resolved fluorescence properties of dye 3b and 3a′ in solid state were evaluated under one-photon excitation at 485 nm. The in vitro cytotoxicity of the new PVP dyes on B16-F10 melanoma cells was evaluated by WST-1 assay, while their intracellular localization was assessed by epi-fluorescence conventional microscopy imaging as well as one- and two-photon excited confocal fluorescence lifetime imaging microscopy (FLIM). PVP dyes displayed low cytotoxicity, good internalization inside melanoma cells and intense fluorescence emission inside the B16-F10 murine melanoma cells, making them suitable staining agents for imaging applications.     

Design of the broadband microstrip array antenna for blast furnace surface monitoring

Aiming at the requirements of high-resolution imaging and high integration of the blast furnace radar,this paper presents a method for designing a wideband microstrip array antenna,which broadens the antenna bandwidth through the design of parasitic patches and air layers.By combining multi-input multi-output (MIMO) radar and synthetic aperture radar (SAR) imaging principles,a linear MIMO array is designed,and a near-field simulation imaging experiment is performed on the simulated feed line through the wave number domain imaging algorithm.Simulation results show that the gain of the main lobe of the antenna can reach 14.05 dBi,the reflection coefficient is less than -10 dB,the absolute bandwidth is 5.25 GHz,the operating frequency is 20.67~25.92 GHz,and the range resolution is increased to 3 cm compared with the existing blast furnace radar.The average error of the azimuth direction of the simulated material line imaging is 0.008 m,and the range direction is 0.0011 m.Compared with the traditional microstrip array antenna,this antenna effectively widens the bandwidth,and the range resolution is higher than that of the traditional blast furnace radar.It can accurately obtain the shape information on the simulated material line,and has an engineering application value for blast furnace surface monitoring.     

分布式PACS通信服务中间层构造方法研究

基于目前分布式PACS中存在的问题,提出一个通信服务中间层的构造方法,分别进行了基于设计模式通信框架的构造、DICOM图像互操作和分布式PACS可复用构件的研究.通信服务中间层的构造不仅提高了分布式PACS在网络异构环境中的可移植性、可扩展性以及相关QoS性能,还满足了PACS今后发展中提出的较高的互连互操作性的要求.     

Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Negatively charged fluorescent carbon dots (CDs, E_m=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD-coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano-carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near-infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.     

Genetic Architecture and Molecular,Imaging and Prodromic Markers in Dementia with Lewy Bodies: State of the Art,Opportunities and Challenges

Dementia with Lewy bodies (DLB) is one of the most common causes of dementia and belongs to the group of α-synucleinopathies. Due to its clinical overlap with other neurodegenerative disorders and its high clinical heterogeneity, the clinical differential diagnosis of DLB from other similar disorders is often difficult and it is frequently underdiagnosed. Moreover, its genetic etiology has been studied only recently due to the unavailability of large cohorts with a certain diagnosis and shows genetic heterogeneity with a rare contribution of pathogenic mutations and relatively common risk factors. The rapid increase in the reported cases of DLB highlights the need for an easy, efficient and accurate diagnosis of the disease in its initial stages in order to halt or delay the progression. The currently used diagnostic methods proposed by the International DLB consortium rely on a list of criteria that comprises both clinical observations and the use of biomarkers. Herein, we summarize the up-to-now reported knowledge on the genetic architecture of DLB and discuss the use of prodromal biomarkers as well as recent promising candidates from alternative body fluids and new imaging techniques.     

Multicomponent Bioluminescence Imaging with Naphthylamino Luciferins

Bioluminescent tools have been used for decades to image processes in complex tissues and preclinical models. However, few distinct probes are available to probe multicellular interactions. We and others are addressing this limitation by engineering new luciferases that can selectively process synthetic luciferin analogues. In this work, we explored naphthylamino luciferins as orthogonal bioluminescent probes. Three analogues were prepared using an optimized synthetic route. The luciferins were found to be robust emitters with native luciferase in vitro and in cellulo. We further screened the analogues against libraries of luciferase mutants to identify unique enzyme-substrate pairs. The new probes can be used in conjunction with existing bioluminescent tools for multi-component imaging.     

涤纶帘子线的等离子体改性

运用等离子体对涤纶帘子线进行改性处理，从而提高涤纶帘子线与橡胶的粘合性，并用X光电子能谱和红外光谱表面分析技术分析改性后的涤纶帘子线表面结构所发生的变化。     

Detection of water ingress in composite sandwich structures: a magnetic resonance approach

Water ingress inside honeycomb sandwich panels during service has been linked to in-flight failure in some aircraft. There is an ongoing effort to develop nondestructive testing methods to detect the presence of water within the panels. Magnetic resonance (MR) represents an attractive approach in that it is sensitive to moisture. Using a unilateral MR sensor, testing can be applied directly to the surface of the panel. The viability of MR is demonstrated through laboratory imaging of both water within sandwich panels, as well as the adhesive itself. The detection of water using a one-sided handheld MR sensor is presented. It is shown that simple detection, as well as spatial localization of water within sandwich panels is possible.     

Preparation and Characterization of K_n|Ga(H_2O)MW_(11)O_(39)|·xH_2O

In this paper the heteropoly complexes K_n[Ga(H_20)MW_(11)O_39)]·xH_20 [M=Cu(Ⅱ), Co(Ⅱ), Cr(Ⅲ),Fe(Ⅲ), Mn(Ⅳ)] have been prepared in this laboratory firstly. The products were characterized by chemicalanalysis, ionexchange, IR, UV and X-ray powder diffraction.