面向鲁棒频谱感知的模糊K-means++算法

恶意用户通过向数据融合中心发送伪造的频谱感知数据,解决自身频谱资源短缺问题,但会极大地降低频谱感知系统的检测概率。为了解决此问题,提出了基于模糊K means++的数据融合算法。该算法首先引入模糊处理机制处理样本的数据特征值,以此来增加样本间的差异性;然后将模糊处理后的数据发送到融合中心,融合中心采用离群点挖掘的方法排除恶意用户,并对保留下来的用户进行融合,使样本向量具有鲁棒性;最后运用K means++算法对样本向量进行聚类。该算法利用轮盘法选择聚类中心,可有效抵御恶意用户的攻击,提高系统感知性能;无需知晓信号与噪声的分布等一些先验信息,也避免了繁杂的门限推导。从仿真结果可以看出,该算法对抵御恶意用户攻击具有突出的效果,有效提升了协同频谱感知系统的稳定性和鲁棒性。     

Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept

Context: The conventional liquid ophthalmic delivery systems exhibit short pre-corneal residence time and the relative impermeability to the cornea which leads to poor ocular bioavailability.

Objective: The aim of this study was to apply quality by design (QbD) for development of dexamethasone sodium phosphate (DSP) and tobramycin sulfate (TS)-loaded thermoresponsive ophthalmic in situ gel containing Poloxamer 407 and hydroxyl propyl methyl cellulose (HPMC) K4M for prolonging the pre-corneal residence time, ocular bioavability and decreases the frequency of administration of dosage form. The material attributes and the critical quality attributes (CQA) of the in situ gel were identified. Central composite design (CCD) was adopted to optimize the formulation.

Materials and methods: The ophthalmic in situ forming gels were prepared by cold method. Materials attributes were the amount of Poloxamer 407 and HPMC and CQA identified were Gel strength, mucoadhesive index, gelation temperature and % of drug release of both drug.

Results and discussion: Optimized batch (F*) containing 16.75% poloxamer 407 and 0.54% HPMC K4M were exhibited all results in acceptable limits. Compared with the marketed formulation, optimized in situ gel showed delayed T_max, improved C_max and AUC in rabbit aqueous humor, suggesting the sustained drug release and better corneal penetration and absorption.

Conclusion: According to the study, it could be concluded that DSP and TS would be successfully formulated as in situ gelling mucoadhesive system for the treatment of steroid responsive eye infections with the properties of sustained drug release, prolonged ocular retention and improved corneal penetration.     

(K0.45Na0.55)0.98Li0.02Nb0.77Ta0.18Sb0.05O3-Co0.85Cu0.15Fe2O4复合陶瓷的磁电性能研究

以压电体(K0.45Na0.55)0.98Li0.02Nb0.77Ta0.18Sb0.05O3和压磁体Co0.85Cu0.15Fe2O4为原料,通过传统的固相反应法制备了(1-x)[(K0.45Na0.55)0.98Li0.02Nb0.77Ta0.18Sb0.05O3]-xCo0.85Cu0.15Fe2O4多铁性复合陶瓷,并使用X射线衍射仪、扫描电子显微镜、压电测试仪、铁电测试仪和磁电耦合测试仪对物相、显微结构、压电、铁电、磁电耦合性能进行了分析。结果表明,复合陶瓷的相结构保持为(K0.45Na0.55)0.98Li0.02Nb0.77Ta0.18Sb0.05O3和Co0.85Cu0.15Fe2O4两种物相,但两者之间发生了轻微的化学反应。随着Co0.85Cu0.15Fe2O4压磁相含量的增加,复合陶瓷的压电系数从56pC/N减小到21pC/N,剩余极化强度略有降低。在压磁相含量为0.2时可获得4.3mV·cm-1·Oe-1的最佳磁电耦合系数。     

K_2CO_3添加对提高Si/C负极电化学性能的作用

本文研究了Si/C锂离子电池负极材料中K_2CO_3的添加对提高电极电化学性能的作用及其作用机理。采用恒流充放电测试和电化学阻抗谱(EIS)研究了不同K_2CO_3添加量对Si/C负极电化学性能的影响;通过扫描电镜(SEM)和傅里叶红外光谱(FTIR)等方法分析了K_2CO_3添加对Si/C负极在循环过程中结构和成分变化的影响。研究结果表明,加入K_2CO_3后,由于电极在循环过程中结构稳定性增强以及电极的固体电解质界面(SEI)膜阻抗和电荷转移阻抗减少,使Si/C负极的循环稳定性和倍率性能得到明显提高。     

基于DSP的变频器控制人机交互接口设计

介绍了一种基于DSP的变频器控制接口电路;在硬件方面,以TMS320LF28035DSP为控制器,基于其EVM板为扩展数字接口和显示模块;软件方面,使用定时器中断对键盘进行管理,在节约DSP硬件资源的同时完成人机交互;电路达到了通用变频器对于数据输入和输出显示的使用要求,利用串并行相互转换芯片起到了节约硬件资源的作用,为变频器实现更多控制功能奠定了基础;与此同时,减少了DSP控制引脚在人机接口方面的数量,增强了电路的可靠性。     

PWM逆变器的一种神经网络控制方法

提出一种用于ＰＷＭ逆变器控制的神经网络控制器、通过仿真和实验研究表明,这种基于动态ＢＰ神经网络的控制器可以使逆变器获得较好的动、静态特性、并且对电源、负载扰动有较强的适应能力。     

组态监控PLC控制的电梯系统

利用组态王软件开发电梯远程监视系统,通过电梯远程监测装置实时监控电梯运行状态,运用PLC技术控制8层观光电梯系统,完成了电梯的运行、电梯门的开合、轿厢内外呼叫应答等功能,并结合变频器,完成了电梯的变频调速。     

变频器非正弦供电对异步电机的影响

介绍变频器非正弦供电对异步电机的影响,分析谐波电压和电流对电机磁路、定子和转子功率因数、电机损耗与效率、谐波转矩、电应力、轴电流产生的危害和如何防止。     

变频器双向双速功能的实现

介绍在Logix5000编程软件中如何添加一台新的PowerFlex70变频器,以及如何通过程序让其实现双向双速功能。