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提出了一种基于CAN总线和LIN总线的混合网络体系.设计了CAN/LIN网关,给出了网关的硬件结构和软件流程.该混合网络体系兼备CAN总线高速数据传送和LIN总线结构简单的特点,成本低、可靠性高、适用范围广. 相似文献
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Lydia Borgelt Dr. Fubao Huang Lisa Hohnen Xiaqiu Qiu Georg L. Goebel Dr. Pascal Hommen Dr. Peng Wu 《Chembiochem : a European journal of chemical biology》2023,24(17):e202300168
Small-molecule inhibitors of the RNA-binding and regulating protein LIN28 have the potential to be developed as chemical probes for biological perturbation and as therapeutic candidates. Reported small molecules disrupting the interaction between LIN28 and let-7 miRNA suffer from moderate to weak inhibitory activity and flat structure-activity relationship, which hindered the development of next-generation LIN28 inhibitors that warrant further evaluations. We report herein the identification of new LIN28 inhibitors utilizing a spirocyclization strategy based on a chromenopyrazole scaffold. Representative compounds 2 – 5 showed potent in vitro inhibitory activity against LIN28-let-7 interaction and single-digit micromolar potency in inhibiting the proliferation of LIN28-expressing JAR cancer cells. The spirocyclic compound 5 incorporated a position that is amenable for functional group appendage and further structural modifications. The binding mode of compound 5 with the LIN28 cold shock domain was rationalized via a molecular docking analysis. 相似文献
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基于OSEK COM规范的车身控制平台的实现 总被引:1,自引:0,他引:1
OSEK/VDX是汽车电子行业的重要标准,其中的通信规范OSEK COM定义了ECU内部和ECU接口之间统一的交互层通信行为。介绍了LIN总线及OSEK COM规范,在自主开发的CAN/LIN总线车身控制平台上设计了符合OSEK COM规范的LIN总线应用软件,并通过实验验证了软件功能的有效性。 相似文献
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针对目前汽车雨刮器质量检测局限于车身、集成度低及兼容性差等缺点,提出一种基于LIN总线技术的雨刮电机自动控制系统;系统由基于VB应用程序的上位机交互端与基于飞思卡尔HCS12系列单片机的下位机控制端组成,通过模拟车身LIN网络通信,实现雨刮电机的参数可配置驱动;实验表明,系统运行稳定,扩展性强,可以作为集成控制模块应用于脱离车身的雨刮器质量检测平台。 相似文献
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Much progress has been achieved in defining methods, techniques, and tools for software architecture reconstruction (SAR). However, less progress has been achieved in constructing reasoning frameworks from existing systems that support organizations in architecture analysis and design decisions. These reasoning frameworks are necessary, for example, to assemble existing components and deploy them in new system configurations. We propose a model‐centric approach where this kind of reasoning is driven by the analysis of quality attribute scenarios. The scenarios and the related quality attribute models guide the SAR effort by focusing on the elicitation of model relevant artifacts. The approach further drives the model construction towards the analytical support of What If scenarios that explore responses stimulated by new requirements, such as new deployments of existing components. The paper provides two real‐world case studies. The first case study introduces the model‐centric reconstruction approach in the context of a large satellite tracking system. The second case study provides the construction of a time performance model for an existing embedded system in the automotive industry. The model allows us to perform cost‐efficient predictions of component assemblies in new customer configurations. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献