关于350兆警用集群通信系统模拟向数字过渡的思考

从安全性、国家产业政策以及公安实战需求方面考虑,350兆警用集群系统由模拟向数字化过度是必然趋势。本文根据吉林省350兆无线通信系统的实际情况,因地制宜,在充分保护现有投资的条件下,探讨全省350兆集群系统的数字化过渡的可行性方案。     

差分吸收相干激光雷达中偏振分集技术研究

为减小差分吸收相干激光雷达(DIAL)中偏振衰落对 回波信号功率反演精度影响,研究了偏振分集技术(PDT)在相干DIAL中 的作用,构建了利用STM32控制的双光束切换DIAL实验装置。依托构 建的装置,利用平衡探 测,分别采用PDT和一般外差探测完成多组次实验,应用单频检测方法得到20m光程下吸收 气体不同浓度下相干中频信号的振 幅值,并由此求解出on光和off光回波信号功率。对回波信号功率值差分信息与由HITRAN得 到的参考差分信息比较 发现:应用PDT能使探测分辨率提高4倍,对应到2km距离内,可以探测到3.5×10－6ppm的CO₂浓度变化,满足了 气候研究所需的优于1％的精度要求,验证了PDT消除偏振衰落以及提高相干DIAL分辨精度的 作用。     

Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease

Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed.     

基于RFID和GPRS技术的城市物流配送系统研究

传统的城市物流配送系统普遍采用的PDT(Portable Data Terminal)虽然携带方便,但是却存在读写距离短、范围小,需要手工更新物流信息等不足.分析了传统城市物流配送系统中存在的一些缺点,提出了一种基于RFID(Radio Frequency Identification)和GPRS技术的城市物流配送系统框架,实现了大范围物流信息的采集、存储以及自动实时传输.详细分析了各组成部分主要功能及各子系统的具体实现.     

Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents

A near-infrared (NIR)-responsive Au_rod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Au_rod@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Au_rod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Au_rod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc₄) as a drug model. It was also demonstrated that the loaded ZnPc₄ could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Au_rod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.     

旋转导向钻井系统控制井眼轨迹机理研究

分析了井眼轨迹的旋转导向机理及井眼轨迹旋转导向偏差矢量控制方法的原理，同时还对常规井眼轨迹控制方法与偏差矢量控制方法进行了比较。     

CPD5的光动力作用及维生素C抗光毒效果

采用细胞排染试验,观察CPD5对人胰癌细胞（Hs766T）的体外光动力疗法（PDT）作用及维生素C减轻光毒的效果。结果表明：1）人胰癌细胞对CPD5 PDT敏感,在CPD5浓度为2．5μg／mL时。PDT造成胰癌细胞抑制率达97．4％;2）浓度为40μg／mL的维生素C有明显的减轻光毒作用,最高可使细胞存活率提高86．0％。     

δ-氨基酮戊酸—光动力疗法对红斑狼疮患者外周血中激活T淋巴细胞的影响

本文探讨了δ-氨基酮戊酸—光动力疗法 (ALA -PDT)对活动期红斑狼疮 (SLE)患者外周血中激活T淋巴细胞的影响。实验采用免疫荧光单标记—流式细胞仪检测 12例活动期SLE患者外周血中CD71阳性淋巴细胞百分比 ,观察其在ALA -PDT前后的变化。发现ALA -PDT能显著降低CD71阳性淋巴细胞百分比 ,ALA -PDT前CD71阳性细胞百分比为 12 31±1 40 ,ALA -PDT后继续培养 18小时下降至 6 5 9± 0 95 ,有非常显著的差异 (P <0 0 1)。本试验证实ALA -PDT能降低活动期SLE外周血中激活T淋巴细胞百分比 ,即可能抑制活动期SLE外周血中激活的T淋巴细胞的活性