用VB实现PPI显示器的仿真

PPI显示器是雷达系统的重要组成部分,也是相关高校学生必备的知识。但相关高校的学生却缺少对其的认识。为了解决这一问题,该文介绍了PPI显示器的基本原理和用VB实现PPI显示器仿真的基本编程方法,仿真结果证明了该方法的有效性。应用该仿真可以弥补相关高校教学中教学工具的不足。     

卷染机中央控制系统

针对多台卷染机实时监测与控制的实际需求,根据西门子S7-200系列PLC的特点设计了一套成本低、扩展性强的基于串口服务器的工业以太网设备联网方案.计算机通过PPI协议同时对多台S7-200 PLC混合存储区多组数据的一次读写技术,实现集中控制多台卷染机,检测设备状态、上传和下载配方和显示主要工艺参数图表的功能.通过调试检测,系统能够平稳的长时间运行,完全可以满足实际使用需要.     

Structural Characterization of Receptor–Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers

G protein-coupled receptor (GPCR) oligomerization, while contentious, continues to attract the attention of researchers. Numerous experimental investigations have validated the presence of GPCR dimers, and the relevance of dimerization in the effectuation of physiological functions intensifies the attractiveness of this concept as a potential therapeutic target. GPCRs, as a single entity, have been the main source of scrutiny for drug design objectives for multiple diseases such as cancer, inflammation, cardiac, and respiratory diseases. The existence of dimers broadens the research scope of GPCR functions, revealing new signaling pathways that can be targeted for disease pathogenesis that have not previously been reported when GPCRs were only viewed in their monomeric form. This review will highlight several aspects of GPCR dimerization, which include a summary of the structural elucidation of the allosteric modulation of class C GPCR activation offered through recent solutions to the three-dimensional, full-length structures of metabotropic glutamate receptor and γ-aminobutyric acid B receptor as well as the role of dimerization in the modification of GPCR function and allostery. With the growing influence of computational methods in the study of GPCRs, we will also be reviewing recent computational tools that have been utilized to map protein–protein interactions (PPI).     

Repurposing of FDA-Approved drugs to predict new inhibitors against key regulatory genes in <i>Mycobacterium tuberculosis</i>

Tuberculosis (TB) disease has become one of the major public health concerns globally, especially in developing countries. Numerous research studies have already been carried out for TB, but we are still struggling for a complete and quick cure for it. The progress of Mycobacterium tuberculosis (MTB) strains resistant to existing drugs makes its cure and control very complicated. Therefore, it is the need of the hour to search for newer and effective drugs that can inhibit an increasing number of putative drug targets. We applied the drug repurposing concept to identify promising FDA-approved drugs against five key-regulatory genes (FurB, IdeR, KstR, MosR, and RegX3) of the MTB. The FDA drugs were virtually screened using a structure-based approach by GOLD versions 5.2, and subjected to rigid docking followed by an induced-fit docking algorithm to enhance the accuracy and prioritize drugs for repurposing. We found 11 candidate drugs (including ZINC03871613, ZINC03871614, ZINC03871615 as top scorer candidate drugs) that were frequently present within the top 20 GoldScore ranks and showed promising results. Furthermore, molecular dynamics simulation was performed to monitor the effect of the top scorer drugs on the structural stability of all the five targets, indicating that inhibitors preferentially bind to the active site of the targets. This work suggests that these known FDA-approved drugs open new application domains in the form of anti-tuberculosis agents.

     

柔性生产线监控网络设计

设计了一套柔性生产线系统,介绍了其控制网络设计及上位机软件的开发方法。     

A computerized model for measuring and benchmarking the partnering performance of construction projects

Research into partnering performance measures for building and construction projects becomes crucial because a growing trend of client organizations has been observed to adopt partnering approach to procure their projects worldwide over the past decade. Although there are some related research studies and papers documented on this research area, few, if any, comprehensive and systematic research studies focus on developing a comprehensive, objective, reliable and practical performance evaluation model for partnering projects in construction. A Partnering Performance Index (PPI), which is composed of seven weighted Key Performance Indicators (KPIs), has been developed to measure, monitor, improve, and benchmark the partnering performance of construction projects in Hong Kong. A set of Quantitative Indicators (QIs) and well-defined ranges of Quantitative Requirements (QRs) for each QI have been further established using the Delphi survey technique and Fuzzy Set Theory. Evaluation of partnering success can now be based on quantitative evidences, thus tackling the subjectivity of performance evaluation. By making use of the Internet and database technology, PPI can be monitored on-line, thus saving much time, cost and efforts on data collection and retrieval than if they are done manually. As such, an Internet-based computerized partnering monitoring and benchmarking tool, namely the Computerized Partnering Performance Index System (CPPIS) has been developed. The Internet-based CPPIS enables project participants to input data at any time and location and the project administrators could perform data analysis via the Internet. The CPPIS also enables project managers to measure, monitor, improve and benchmark their partnering performances against those already stored in the database. Graphical presentations of data and various performance measures are also built in to assist various end-users to identify problematic areas and critical success factors for achieving partnering excellence.     

视频采集接口的设计与实现

利用Blackfin DSP特有的PPI接口设计了视频采集接口,其特点是数据采集过程独立于DSP内核。并给出了采集程序实例。试验证明,PPI接口传输速率高,可实现低功耗下的高速数据传输。     

高PPI产品下的取向膜画面品质改善研究

为了实现TFT LCD高PPI产品的高分辨率,高开口率,低功耗全面提升,分析了不同因素的影响程度,加强了对取向膜印刷品质的管控。同时对涉及该过程相关因素进行研究分析。对取向膜画面品质相关的产线印刷和干燥条件、APR版制作工艺、取向膜膜厚变化、APR版线数开口率进行优化测试,找到了可以提高取向膜画面品质的方法。实验结果表明:通过对取向膜印刷和干燥条件优化,确定了TN产品画面品质提升的产线管控方案;在APR版制作过程中引用扩散保护膜,ADS产品Particle类不良降低2%,Scratch类不良降低1%;对取向膜膜厚提升,ADS产品的段差和残像得到改善,对比度提升30~120,Zara Particle不良降低30%;通过对APR版的网点,开口率优化:400L,30%,普通曝光的APR版更新为600L,20%,高PPI有机膜类产品的Sand Mura发生率降低为0%。可以满足高PPI产品对取向膜印刷稳定的管控要求,适应高分辨率、高开口率、低功耗等要求。     

基于DSP+FPGA视频图像采集处理系统的设计

针对图像采集与处理的应用要求,提出了基于双核DSP搭配FPGA的构架设计,DSP作为主处理器,通过其专用的PPI视频接口配合DMA控制器控制视频图像的采集、存储,并完成目标识别;FPGA作为协处理器,完成图像预处理中的累乘加运算并且为DSP提供部分寄存器扩展。阐述了系统的工作原理及各功能模块的构成,设计了图像采集处理系统,实现了视频图像的实时采集与处理。实验结果表明:系统可对25frames/s、16bit、720×576像素的视频图像进行采集与处理,具有良好的实时性。