基于可编程控制器的分布式多机通讯原理及应用

本文结合工程实例介绍了Ｓ７－２００系列可编程控制器的功能和特点；讨论了用工业控制计算机、可编程控制器以及单片机组成的分布式控制系统在闸门实时监控系统中的应用，并详细分析了上、下位机之间的通信方式及其功能的具体实现。     

火控雷达终端模拟

基于Delphi的火控雷达终端模拟系统,用于雷达平面显示器、目标、目标捕获、杂波等模拟.主界面含平面位置显示器(PPI)、目标状态信息显示区、系统控制设置区及目标高度显示部分.系统根据目标运动方程产生一定轨迹的飞行目标,在模拟的雷达PPI显示器中显示目标回波,运用多线程技术,实现目标的捕获跟踪模拟.     

基于PC的PPI显示系统的设计与实现

介绍一种基于PC的PPI显示系统的设计与实现。为满足雷达回波实时显示的要求,研究了距离-方位极坐标与光栅显示直角坐标的快速转换算法;为实现传统PPI显示器荧光点余辉效应的模拟,提出了基于回波数据上报周期递减显示像素色深的方法;为满足叠加数字地图和航迹等信息的要求,提出了基于图层的显示数据管理算法。文中提出的设计和算法较好地满足了上述功能和性能要求,研究成果应用于某目标探测系统取得了较好的效果。     

Protein-Protein Interaction Modeling and Inhibition: The TAU Bioinfo3D Perspective

Protein-protein interactions are central to cell function. In order to fully understand these interactions, one has to elucidate the three-dimensional structures of the underlying complexes. While experimental methods have advanced significantly in the last decade, there are still few structures of protein complexes in the Protein Data Bank. Reliable computational techniques are required to fill in this gap. Better understanding of protein-protein interactions has also opened a large number of potential targets for the pharmaceutical industry, which previously viewed these interactions as “undruggable”. In this review, we focus on the algorithms developed by the Tel Aviv University Structural Bioinformatics (Bioinfo3D) Lab to model protein-protein interactions, and on a preliminary attempt to search for peptide inhibitors for these interactions. All the algorithms presented are among the fastest available today and can be accessed via the group web server.     

变频器、PLC在水处理实验监控系统中的应用

介绍了使用上位机、S7-200系列PLC和MMV变频器来实现水处理系统中的变频调速的监控方案,分析了该系统的主要组成部分及特性。系统自动化部分主要实现的功能为:动态采集数据、数据分析处理、自动控制功能、集中显示功能、工艺参数设定功能、数据存储功能、查询功能、报表及打印功能等。     

几种特殊动态特性对象的预测PI控制

提出了基于一阶加纯滞后、二阶非振荡及振荡加纯滞后、反向特性加纯滞后和积分特性加纯滞后对象的预测 PI控制器的结构形式。这种预测 PI控制器既具有 PI控制器的功能 ,又具有预测功能 ,特别适合大纯滞后系统的控制 ,而且结构简单 ,可调参数少 ,参数的调节方便、直观。通过几种实际对象的模型仿真表明 :在干扰、噪音存在和模型失配的情况下 ,预测 PI控制器仍然具有良好的控制性能 ,是一种值得在实际工程中推广应用的新型控制器     

基于PPI协议的注浆参数采集和网络发布系统

为了提高注浆参数监测质量,应用VC技术编制了基于PPI通信协议的注浆参数采集软件,实现了注浆水枪远程监控、注浆参数采集和存储功能;应用ASP.NETAJAX技术和Web服务环境IIS开发实时、动态、无闪烁的Web页面,实现了注浆信息网络发布。     

基于迁移学习的蛋白质交互关系抽取

作为生物医学信息抽取领域的重要分支,蛋白质交互关系(Protein-Protein Interaction,PPI)抽取具有重要的研究意义。目前的研究大多采用统计机器学习方法,需要大规模标注语料进行训练。训练语料过少,会降低关系抽取系统的性能,而人工标注语料需要耗费巨大的成本。该文采用迁移学习的方法,用大量已标注的源领域(其它领域)语料来辅助少量标注的目标领域语料(本领域)进行蛋白质交互关系抽取。但是,不同领域的数据分布存在差异,容易导致负迁移,该文借助实例的相对分布来调整权重,避免了负迁移的发生。在公共语料库AIMed上实验,两种迁移学习方法获得了明显优于基准算法的性能;同样方法在语料库IEPA上实验时,TrAdaboost算法发生了负迁移,而改进的DisTrAdaboost算法仍保持良好迁移效果。     

C9ORF72 Repeat Expansion Affects the Proteome of Primary Skin Fibroblasts in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of the corticospinal motor neurons, which ultimately leads to death. The repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) represents the most common genetic cause of ALS and it is also involved in the pathogenesis of other neurodegenerative disorders. To offer insights into C9ORF72-mediated pathogenesis, we quantitatively analyzed the proteome of patient-derived primary skin fibroblasts from ALS patients carrying the C9ORF72 mutation compared with ALS patients who tested negative for it. Differentially expressed proteins were identified, used to generate a protein-protein interaction network and subjected to a functional enrichment analysis to unveil altered molecular pathways. ALS patients were also compared with patients affected by frontotemporal dementia carrying the C9ORF72 repeat expansion. As a result, we demonstrated that the molecular pathways mainly altered in fibroblasts (e.g., protein homeostasis) mirror the alterations observed in C9ORF72-mutated neurons. Moreover, we highlighted novel molecular pathways (nuclear and mitochondrial transports, vesicle trafficking, mitochondrial bioenergetics, glucose metabolism, ER-phagosome crosstalk and Slit/Robo signaling pathway) which might be further investigated as C9ORF72-specific pathogenetic mechanisms. Data are available via ProteomeXchange with the identifier PXD023866.     

PPI协议分析

使用软件监听串口,记录Step7-Micro/SIN与S7-200 PLC通讯的PPI协议报文,参照PROFIBUS总线通讯协议,分析出PPI协议报文关键帧格式,实现读、写、锁定、解锁、连接测试、开停PLC等常用功能,可用于开发基于S7-200系列PLC、使用PPI协议进行通讯的上位机程序或轻量级的现场设备.