Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets

Inositol 1,4,5-triphosphate receptor-associated 2 (IRAG2) is a type II membrane protein located at the endoplasmic reticulum. It is a homologue of inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate 1 (IRAG1), a substrate protein of cGMP-dependent protein kinase I (PKGI), and is among others expressed in platelets. Here, we studied if IRAG2 is also located in platelets and might be a substrate protein of PKGI. IRAG2 was detected in platelets of IRAG2-WT animals but not in those of IRAG2-KO animals. Next, we validated by co-immunoprecipitation studies that IRAG2 is associated with IP₃R1-3. No direct stable interaction with PKGIβ or with IRAG1 was observed. Phosphorylation of IRAG2 in murine platelets using a Ser/Thr-specific phospho-antibody was found in vitro and ex vivo upon cGMP stimulation. To gain insight into the function of IRAG2, platelet aggregation studies were performed using thrombin and collagen as agonists for treatment of isolated IRAG2-WT or IRAG2-KO platelets. Interestingly, platelet aggregation was reduced in the absence of IRAG2. Pretreatment of wild type or IRAG2-KO platelets with sodium nitroprusside (SNP) or 8-pCPT-cGMP revealed a further reduction in platelet aggregation in the absence of IRAG2. These results show that IRAG2 is a substrate of PKGI in murine platelets. Furthermore, our results indicate that IRAG2 is involved in the induction of thrombin- or collagen-induced platelet aggregation and that this effect is enhanced by cGMP-dependent phosphorylation of IRAG2. As IRAG1 was previously shown to inhibit platelet aggregation in a cGMP-dependent manner, it can be speculated that IRAG2 exerts an opposing function and might be an IRAG1 counterpart in murine platelets.     

Group dynamics and record signals in the ant Temnothorax albipennis

Many purely physical complex systems, in which there are both stochasticity and local interactions between the components, exhibit record dynamics. The temporal statistics of record dynamics is a Poisson process operating on a logarithmic rather than a linear time scale (i.e. a log-Poisson process). Record dynamics often drive substantial changes in complex systems when new high water marks in partially stochastic processes trigger new events. Social insect colonies are exemplary complex biological systems in which many of the local interactions of the components have been moulded by natural selection for the common good. Here, we combine experimental manipulation of ant colony demography with modelling to test the hypothesis that social interactions are the mechanism underlying the record dynamics. We found that compared with the control, log-Poisson statistics were disrupted in colonies in which the pattern of interactions was modified by the removal of the brood, and disappeared completely in ‘callow’ colonies composed entirely of very young workers from the same age cohort. We conclude that a subtle interplay between the demography of the society and the pattern of the interactions between the ants is crucial for the emergence of record dynamics. This could help identify what makes an ant colony a cohesive society.     

基于协作信誉和设备反馈的物联网边缘服务器信任评估算法

针对边缘服务器的安全问题,提出了一种集成了服务器协作信誉以及设备用户反馈的信任评估算法来提高边缘计算上下文的安全性.交互过程中,使用了一种基于客观信息熵理论的融合算法来聚合服务器间的协作信誉,同时采用了部分同态加密算法来防止交互过程中用户数据的泄露.交互结束后,选择高可信的设备节点计算反馈信任,克服了传统机制的恶意反馈...     

X-MAC:一种新型的无线传感器网络MAC协议﹡

在无线传感器网络体系结构中,MAC(Medium Access Control)协议是保证网络高效通信的重要协议.无线传感器网络有着与传统无线网络明显不同的性能特点和技术要求.对于很多的 MAC 层协议而言,吞吐量很大程度上受到了物理信道的利用率和协议开销的限制.这里设计了一种基于一对多拓扑的无线传感器Mac层网络协议.最后,还通过NS-2(Network Simulator 2)仿真并比较该协议与现存无线传感器MAC层网络协议的网络性能.     

Achieving High‐Performance Nondoped OLEDs with Extremely Small Efficiency Roll‐Off by Combining Aggregation‐Induced Emission and Thermally Activated Delayed Fluorescence

Luminescent materials with thermally activated delayed fluorescence (TADF) can harvest singlet and triplet excitons to afford high electroluminescence (EL) efficiencies for organic light‐emitting diodes (OLEDs). However, TADF emitters generally have to be dispersed into host matrices to suppress emission quenching and/or exciton annihilation, and most doped OLEDs of TADF emitters encounter a thorny problem of swift efficiency roll‐off as luminance increases. To address this issue, in this study, a new tailor‐made luminogen (dibenzothiophene‐benzoyl‐9,9‐dimethyl‐9,10‐dihydroacridine, DBT‐BZ‐DMAC) with an unsymmetrical structure is synthesized and investigated by crystallography, theoretical calculation, spectroscopies, etc. It shows aggregation‐induced emission, prominent TADF, and interesting mechanoluminescence property. Doped OLEDs of DBT‐BZ‐DMAC show high peak current and external quantum efficiencies of up to 51.7 cd A^?1 and 17.9%, respectively, but the efficiency roll‐off is large at high luminance. High‐performance nondoped OLED is also achieved with neat film of DBT‐BZ‐DMAC, providing excellent maxima EL efficiencies of 43.3 cd A^?1 and 14.2%, negligible current efficiency roll‐off of 0.46%, and external quantum efficiency roll‐off approaching null from peak values to those at 1000 cd m^?2. To the best of the authors' knowledge, this is one of the most efficient nondoped TADF OLEDs with small efficiency roll‐off reported so far.     

基于蚁群算法的无线传感器网络数据聚合路由算法

传感器网络为减少冗余数据的传输耗能。降低延迟,需要在路由过程中采用数据聚合技术。文中采用定向传输方式,在消息路由机制基础上提出了一种基于蚁群算法的数据聚合路由算法。该算法主要思想在于将节点能耗、传输距离与聚合收益3方面作为启发因子,通过一组称为“蚂蚁”的人工代理寻找到达汇聚节点的最优路径。该算法利用蚁群算法的正反馈效应来达到数据汇集的目的,不需要网络节点维护全局信息,因此是一种实现数据聚合在能量与时延上折中的分布式路由算法。理论分析和仿真结果说明了新算法的有效性。     

LTE-A载波聚合技术研究及在PDCCH盲检测中的应用

阐述了载波聚合关键技术的最新进展,具体介绍了载波聚合技术在PDCCH盲检测中的应用,以及支持跨载波调度和不支持跨载波调度两种方式下的盲检测方法和各自优缺点。通过C语言搭建链路,对两种调度方式的性能进行了仿真,为LTE-A系统的实现提供了理论依据。     

RRU与天线一体化设备在TD—LTE网络建设中的应用研究

在TD—LTE网络建设中,由于TD—LTE采用的频段较高（2GHz以上）,使得新建网络需要增加较多站点。然而对于部分天面资源匮乏的站点,采用传统的新建抱杆、新增RRu＋天线的方式将面临诸多困难。介绍了RRU与天线一体化的新形态设备用于解决天馈紧张站点的TD-LTE网络建设方案,并详细对比分析了RRu天线一体化与传统RRU＋天线方案的差异,最后对RRU与天线一体化设备的应用场景提供了详细的建议,用于指导TD-LTE网络建设。     

High energy‐efficient and privacy‐preserving secure data aggregation for wireless sensor networks

An efficient data process technology is needed for wireless sensor networks composed of many sensors with constrained communication, computational, and memory resources. Data aggregation is presented as an efficient and significant method to reduce transmitted data and prolong lifetime for wireless sensor networks. Meanwhile, many applications require preserving privacy for secure data aggregation. In this paper, we propose a high energy‐efficient and privacy‐preserving scheme for secure data aggregation. Because of the importance of communication overhead and accuracy, our scheme achieves less communication overhead and higher data accuracy besides providing for privacy preservation. For extensive simulations, we evaluate and conclude the performance of our high energy‐efficient and privacy‐preserving scheme. The conclusion shows that the high energy‐efficient and privacy‐preserving scheme provides better privacy preservation and is more efficient than existing schemes. Copyright © 2012 John Wiley & Sons, Ltd.     

大鼠缺血性卒中光化学模型研究

本文基于光化学反应机理，对大鼠缺血性卒中光化学模型进行研究，指出光化学反应诱导ＶＥＣ功能异常，从而加速了血小板聚集，导致血管栓塞。该模型制作简单，相对非侵害，有可能替代大脑动脉闭塞的缺血性卒中模型。