H_3PW_6Mo_6O_(40)·nH_2O催化过氧化氢清洁氧化环己酮合成己二酸

以自制H3PW6Mo6O40.nH2O为催化剂,在无有机溶剂、相转移催化剂的情况下,用过氧化氢氧化环己酮合成己二酸。探讨了催化剂用量、过氧化氢用量、反应时间、反应温度对反应的影响。确定了最佳反应条件为n(环己酮)∶(n磷钼钨杂多酸)∶(n过氧化氢)=100∶0.15∶400,在90℃反应5h,己二酸的分离收率达75.8%。     

金堆城钼细泥过滤脱水应用研究

对在“57钼精矿”生产过程中产生的用常规过滤无法进行脱水的钼细泥，用TT系列陶瓷过滤机进行脱水研究。完全解决了钼细泥的脱水问题。保证了“57钼精矿”生产工艺的畅通。     

基于泥沙冲淤数值模拟的水库调度方案研究

以东台子水库为研究对象,基于一维不饱和全沙数值模型,研究蓄洪运用方案、蓄洪排沙运行方案、分阶段蓄洪运用方案、蓄清排浑运用方案等四种水库调度方式下的泥沙淤积情况,力图在兴利防洪的基础上尽量利用弃水排沙,保持有效库容。对不同运行年限的淤积量、水库库容变化和排沙比等要素的模拟研究表明,分阶段蓄洪运用或蓄清排浑运用方案更有利于保持有效库容,对延长水库使用寿命具有一定作用,是较优的水库排沙优化调度方案。     

模糊集理论推出的一个错误定理

以实例说明了模糊集中的排中律不成立产生的原因,且指明文献[1]中提出的取大取小的不完备性应如何纠正。     

A new method on hydrothermal scheduling optimization in electric power market

The hydrothermal scheduling in the electric power market becomes difficult because of introducing competition and considering sorts of constraints. An augmented Lagrangian approach is adopted to solve the problem,which adds to the standard Lagrangian function a quadratic penalty term without changing its dual property,and reduces the oscillation in iterations. According to the theory of large system coordination and decomposition,the problem is divided into hydro sub-problem and thermal sub-problem,which are coordinated by updating the Lagrangian multipliers,then the optimal solution is obtained. Our results for a test system show that the augmented Lagrangian approach can make the problem converge into the optimal solution quickly.     

Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells

Mutations in the Von Hippel–Lindau (VHL) gene are the driving force in many forms of clear cell renal cell carcinoma (ccRCC) and promote hypoxia-inducible factor (HIF)-dependent tumor proliferation, metastasis and angiogenesis. Despite the progress that has already been made, ccRCC generally remain resistant to conventional therapies and ccRCC patients suffer from metastasis and acquired resistance, highlighting the need for novel therapeutic options. Cysteinyl leukotriene receptor 1 (CysLTR1) antagonists, like zafirlukast, are administered in bronchial asthma to control eicosanoid signaling. Intriguingly, long-term use of zafirlukast decreases cancer risk and leukotriene receptor antagonists inhibit tumor growth, but the mechanisms still remain unexplored. Therefore, we aim to understand the mechanisms of zafirlukast-mediated cell death in ccRCC cells. We show that zafirlukast induces VHL-dependent and TNFα-independent non-apoptotic and non-necroptotic cell death in ccRCC cells. Cell death triggered by zafirlukast could be rescued with antioxidants and the PARP-1 inhibitor Olaparib, and additionally relies on HIF-2α. Finally, MG-132-mediated proteasome inhibition sensitized VHL wild-type cells to zafirlukast-induced cell death and inhibition of HIF-2α rescued zafirlukast- and MG-132-triggered cell death. Together, these results highlight the importance of VHL, HIF and proteasomal degradation in zafirlukast-induced oxidative cell death with potentially novel therapeutic implications for ccRCC.     

富硒猕猴桃果醋发酵关键技术研究

以富硒猕猴桃为主要原料研制果醋饮料,应用单因素和正交试验的方法研究富硒猕猴桃果醋的澄清和发酵过程中的关键技术,确定了最佳发酵条件：最佳醋酸发酵醪的适宜酒精含量为5.5%,发酵温度32℃,发酵时间96h,接种量10%;将澄清剂和果胶酶复合使用,果胶酶用量为0.05%,澄清剂用量为0.08‰-0.12‰。分析了果醋中硒的含量。     

“四全”清液型系列复合肥产品的防结块措施

针对云南云天化股份有限公司云峰分公司研发生产的"四全"清液型系列复合肥产品易结块问题,通过对产品结块原因机制的分析,从防结块剂的选择、生产工艺、包装方面以及防结块剂用量等方面采取一系列的防结块措施。最终选择水分含量低、产品溶解后表面无油迹的全水溶固体粉末状防结块剂;在生产工艺方面提高冷却效率、将包装温度冷却到35℃以下,确保产品彻底冷却;确定包装环节采用双内袋,小包装;防结块剂用量为1 t产品2 kg防结剂。     

武汉工业学院新校区图书馆设计

通过对武汉工业学院新校区图书馆的方案设计,对现代图书馆的建筑设计特点进行了研究,指出其平面采用集约化布局方式,将编、藏、借、阅各区独立设置,分区明确,以建造出内部空间布局合理、视觉效果独特、文化内涵丰富的现代图书馆。     

Production of microparticles from milk fat products using the Supercritical Melt Micronization (ScMM) process

The ScMM (Supercritical Melt Micronization) process was applied for the production of microparticles from anhydrous milk fat (AMF) and a diacylglycerol-based modified milk fat (D-AMF). Both fats were able to dissolve ca. 30 wt% CO₂ in the studied pressure and temperature ranges, being the CO₂ amount slightly higher for AMF. A melting point depression was observed in both systems in the presence of CO₂. Two powder morphologies were obtained (spherical hollow particles and a mass sponge-like broken particles) depending on the ScMM process conditions. The concentration of CO₂ in the fat melt was the main process variable affecting the particle morphology, followed by the temperature of the melt. The small broken particles originated from the breakage of spherical fat particles that solidified before all CO₂ could escape from the atomized droplets. While the hollow spheres had a tendency to agglomerate, the broken microparticles constituted a free-flowing powder as long as they were stored at low temperatures (up to −18 °C). Both types of particles have a potential for being incorporated in refrigerated or frozen food products as a structuring agent.