NVP-HEMA角膜接触镜材料的透氧性能

以过氧化二苯甲酰(BPO)为引发剂，N-乙烯基吡咯烷酮(NVP)和甲基丙烯酸β-羟乙酯(HEMA)在一定温度下共聚得水凝胶，可作为软性角膜接触镜材料．实验发现，随NVP含量的增大，水凝胶的含水量越大，透氧性增大，水凝胶材料的透氧率(Dk／L)的倒数与其厚度成正比．并自行设计了一套角膜接触镜材料透氧性能的测试装置、     

角膜移植显微手术机器人末端执行器的设计

设计了一种用于角膜移植显微手术机器人系统的末端执行器.末端执行器集成了微力传感器、位移传 感器.微型直流电机和环钻，具有体积小、功能完善的特点.它用于系统末端，直接对角膜进行操作.􀁱     

利用离体牛角膜多次暴露方法评测化妆品套装的眼刺激性

采用标准和改良的牛角膜浑浊度和渗透性(BCOP)试验对市售5种化妆品洗护套装进行评测,并比较不同方案下渗透性和浑浊度2个参数的变化,初步建立多次眼暴露的离体牛角膜试验体外评价方法。结果表明,采用标准方法套装内单个产品均显示无眼刺激性,而多次暴露后,发现角膜浑浊度和渗透性均出现了不同程度的变化,可能产生眼刺激性。改良后的BCOP测试方法可用于多次暴露的眼刺激性评价,为产品安全性的提升提供了参考。     

激光角膜热成形术中的角膜建模技术

针对当前用于远视治疗的激光角膜热成形手术,对手术前后角膜的变化进行合理化假设,由此提出了一种预测激光角膜热成形远视治疗手术矫正效果的角膜建模方法,并且分析了这种建模方法的优缺点及适用范围.     

Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum

Over the last three decades, there has been special interest in developing drugs that mimic the characteristics of natural tears for use it in the treatment of several ocular surface disorders. Interestingly, the composition of blood plasma is very similar to tears. Therefore, different blood-derived products like autologous serum (AS) and plasma rich in growth factors (PRGF) have been developed for the treatment of diverse ocular pathologies. However, scarce studies have been carried out to analyze the differences between both types of blood-derived products. In the present study, blood from three healthy donors was drawn and processed to obtain AS and PRGF eye drops. Then, human corneal stromal keratocytes (HK) were treated with PRGF or undiluted AS. Proteomic analysis was carried out to analyze and characterize the differential protein profiles between PRGF and AS, and the differentially expressed proteins in HK cells after PRGF and AS treatment. The results obtained in the present study show that undiluted AS induces the activation of different pathways related to an inflammatory, angiogenic, oxidative stress and scarring response in HK cells regarding PRGF. These results suggest that PRGF could be a better alternative than AS for the treatment of ocular surface disorders.     

The Role of Eph Receptors and Ephrins in Corneal Physiology and Diseases

The cornea, while appearing to be simple tissue, is actually an extremely complex structure. In order for it to retain its biomechanical and optical properties, perfect organization of its cells is essential. Proper regeneration is especially important after injuries and in the course of various diseases. Eph receptors and ephrin are mainly responsible for the proper organization of tissues as well as cell migration and communication. In this review, we present the current state of knowledge on the role of Eph and ephrins in corneal physiology and diseases, in particular, we focused on the functions of the epithelium and endothelium. Since the role of Eph and ephrins in the angiogenesis process has been well established, we also analyzed their influence on conditions with corneal neovascularization.     

玉木耳多糖对小鼠的抗疲劳作用

目的：以玉木耳多糖为原料，探寻其对小鼠的抗疲劳作用。方法：以雄性昆明小鼠为研究对象，在正常饮食中加入50~200 mg/kg的玉木耳多糖（Auricularia cornea Polysacchrides，AP），考察其对小鼠抗疲劳能力的影响。结果：AP对小鼠体重无显著影响，但AP100和AP200处理组可显著提升小鼠力竭游泳时间（P＜0.05）；在小鼠游泳运动30 min后，AP200处理组较对照组显著提升肝糖原和肌糖原的储备、抑制血清中乳酸和尿素氮的堆积（P＜0.05），还可以显著降低机体自由基水平、提高SOD和GSH-Px含量（P＜0.05）。结论：AP具有提高小鼠运动耐性，提升小鼠抗疲劳能力的作用。     

基于图像处理的角膜混浊度分析方法的研究

本文根据医学眼科图像的特点，提出了一种自动分析角膜混浊度的算法，能很好地消除图像中的光斑及弱光影响，实验结果表明，该算法能有效地分析角膜的混浊程度，且有较好的鲁棒性。     

193nm准分子激光及超短脉冲激光角膜切削

193nm准分子激光和费秒级超短脉冲激光因其能对角膜进行精确的切削 ,对临近组织造成的损伤很小 ,已经成为屈光手术领域研究的热点。本文首先研究 193nm准分子激光 ,费秒级超短脉冲激光对角膜的切削机理 ,建立激光脉冲参数与角膜组织切削量之间的数学模型并在此基础上对比分析两种激光切削角膜的特征及其在屈光手术领域的应用。