A hybrid clustering and graph based algorithm for tagSNP selection

TagSNP selection, which aims to select a small subset of informative single nucleotide polymorphisms (SNPs) to represent the whole large SNP set, has played an important role in current genomic research. Not only can this cut down the cost of genotyping by filtering a large number of redundant SNPs, but also it can accelerate the study of genome-wide disease association. In this paper, we propose a new hybrid method called CMDStagger that combines the ideas of the clustering and the graph algorithm, to find the minimum set of tagSNPs. The proposed algorithm uses the information of the linkage disequilibrium association and the haplotype diversity to reduce the information loss in tagSNP selection, and has no limit of block partition. The approach is tested on eight benchmark datasets from Hapmap and chromosome 5q31. Experimental results show that the algorithm in this paper can reduce the selection time and obtain less tagSNPs with high prediction accuracy. It indicates that this method has better performance than previous ones.     

公选课教学改革的研究和实践

公共选修课设置的目的是为了拓宽学生的知识面,培养学生的多种技能,从而提高学生的综合素质,以期适应社会发展的要求。本文就公共选修课在教学上存在的问题,以"网络实用技术"公共选修课为例,提出具体的改革措施,实践证明,该措施有效地提高公共选修课教学质量。     

Boosting the confidence of new product development teams: The role of team boundary spanning,team size and functional diversity

In today's highly interconnected, uncertain and dynamic business environment, team boundary spanning has become an important determinant of the performance of new product development (NPD) projects. Despite the positive evidence supporting the use of boundary spanning activities by NPD teams, little is still known about how boundary spanning teams become high-performance teams. The current study advances research on this subject by examining the mediating effect of team potency on the relationship between team boundary spanning and new product performance, as well as the moderating effects of team size and functional diversity on the relationship between team boundary spanning and team potency. Data from a time-lagged survey study of 140 NPD projects found that team boundary spanning can promote team potency that, in turn, results in greater new product quality and new product creativity. The positive effect of team boundary spanning on team potency was found to be more pronounced for NPD teams of medium size and high levels of functional diversity.     

选择并融合粗细粒度特征的细粒度图像识别

目的 在细粒度图像识别任务中,类内图像姿势方差大,需要找到类内变化小的共性,决定该任务依赖于鉴别性局部的细粒度特征;类间图像局部差异小,需要找到类间更全面的不同,决定该任务还需要多样性局部的粗粒度特征。现有方法主要关注粗细粒度下的局部定位,没有考虑如何选择粗细粒度的特征及如何融合不同粒度的特征。为此,提出一种选择并融合粗细粒度特征的细粒度图像识别方法。方法 设计一个细粒度特征选择模块,通过空间选择和通道选择来突出局部的细粒度鉴别性特征;构建一个粗粒度特征选择模块,基于细粒度模块选择后的局部,挖掘各局部间的语义和位置关系,从而获得为细粒度局部提供补充信息的粗粒度多样性特征;融合这两个模块中提取到的细粒度特征和粗粒度特征,形成互补的粗细粒度表示,以提高细粒度图像识别方法的准确性。结果 在CUB-200-2011（caltech-UCSD birds-200-2011）、Stanford Cars和FGVC-Aircraft（fine-grained visual classification aircraft） 3个公开的标准数据集上进行广泛实验,结果表明,所提方法的识别准确率分别达到90.3%、95.6%和94.8%,明显优于目前主流的细粒度图像识别方法,相较于对比方法中的最好结果,准确率相对提升0.7%、0.5%和1.4%。结论 提出的方法能够提取粗粒度和细粒度两种类型的视觉特征,同时保证特征的鉴别性和多样性,使细粒度图像识别的结果更加精准。     

Firm diversity and data breach risk: A longitudinal study

Research has extensively investigated the rationale of firm diversity from the economic perspective, but little is known about how such a strategy may affect information security. The present study is the first to examine how firm diversity is relevant to firms’ likelihood to experience data breaches (i.e., data breach risk). Drawing from the strands of literature on information security, diversification, and resource-based view, we propose hypotheses on the relationship between firm diversity and data breach risk, as well as the boundary conditions of this relationship. On the basis of a twelve-year sample of publicly-listed firms, our analysis provides evidence to support the negative association between firm diversity and data breach risk. Our analysis also delineates conditions under which the effects of firm diversity can intervene to reduce the data breach risk invoked, such as under related diversity and when managers are managerially capable. For academics, our research accentuates an intriguing but unexamined benefit of firm diversity because it relates to information security. For practicing professionals, this research highlights the significant impact of firms’ operational structure on information security.     

低功耗高速时钟数据恢复电路

为了降低高速串行接口的时钟数据恢复(CDR)电路的功耗,在研究、分析现有时钟数据恢复结构的基础上,提出了一种新的时钟数据鉴相算法及其电路实现方法。新的电路设计仅使用一个高速采样时钟,比传统的鉴相电路减少一半的采样率,从而减少了前端采样模块的功耗。该鉴相算法采用统计方法减小鉴相时钟的噪声,进而达到很低的误码率。该鉴相算法可使用数字综合的方法实现,工作在较低的频率下,这样便于迁移到不同的工艺中。整个电路使用40nm工艺实现,实际芯片测试数据表明,使用该电路的接收端可以稳定工作在13Gb/s的速率下,功耗达到0.83p J/bit,误码率低于10E-12。     

异质性和时滞作用下神经元网络的共振动力学

利用参数互异的Fitzhugh-Nagumo神经元构建了含耦合时滞的无标度神经元网络模型,通过数值模拟的方法,提出研究参数异质性和耦合时滞影响下神经元网络的共振动力学.结果发现,当耦合项中不含时滞时,适中的参数异质性能够使得神经元网络对外界弱周期信号的响应达到最优,即适中的参数异质性能够诱导神经元网络的共振响应,而且异质性诱导共振对耦合强度具有鲁棒性.更重要的是,耦合时滞对参数异质性作用下神经元网络的共振特性也有着显著性影响.当时滞约为信号周期的整数倍时,神经元网络能够周期性地出现共振现象,即适当的耦合时滞能够诱导神经元网络的多重共振,而且这种现象在异质性参数的适当范围内都能明显出现.     

A fully differential transimpedance amplifier with integrated differential photodetector in standard CMOS process for optical communications and interconnects

A fully differential transimpedance amplifier (TIA) with integrated differential photodetector in standard CMOS technologies has been realized for optical receivers in optical communications and optical interconnects. And a novel, fully differential photodetector aiming to convert the incident light into a pair of fully differential photo-generated currents and ensure the differential symmetry on circuit configuration and model has also been proposed for the differential TIA to achieve the fully differentia...     

A low-jitter low-power monolithically integrated optical receiver for SDH STM-16

A high-scale integrated optical receiver including a preamplifier, a limiting amplifier, a clock and data recovery (CDR) block, and a 1:4 demultiplexer (DEMUX) has been realized in a 0.25 μm CMOS technology. Using the loop parameter optimization method and the low-jitter circuit design technique, the rms and peak-to-peak jitter of the recovered 625 MHz clock are 9.4 and 46.3 ps, respectively, which meet the jitter specifications stipulated in ITU-T recommendation G.958. In response to 2.5 Gb/s PRBS input da...     

Heterodyne mixing and polarization diversity techniques in radio over fiber system with high sensitivity and dispersion tolerance

We propose and experimentally demonstrate the heterodyne mixing and polarization diversity tech- niques in radio over fiber (ROF) systems with the advantages of high sensitivity and dispersion endurance. The generation of 2.5 Gb/s optical DPSK and PSK signals, fiber propagation and wireless transmission over 15 GHz subcarrier are illustrated with very low sensitivity of -26 and -32 dBm, respectively. Moreover, based on the wireless polarization diversity techniques, we successfully performed the t...