关于正项几何规划的对偶规则

本文利用著名的 Lagrange 函数理论直接地建立了正项几何规划的对偶规划,而没有利用算术——几何不等式及(h一Φ))凸函数理论。     

Identification of a potent inhibitor of human dual-specific phosphatase, VHR, from computer-aided and NMR-based screening to cellular effects

Human vaccinia H1-related phosphatase (VHR) is a dual-specific phosphatase (DSPs) that plays an important role in the mitogen-activated protein (MAP) kinase cascade regulation. It is also a potential drug target for diseases that are related to immune response. By combining a virtual and NMR-based ligand-screening strategy, we successfully identified four VHR inhibitors, of which GATPT ((glucosamine-aminoethoxy)triphenyltin) can bind to VHR with a K(i) value of 2.54 muM. The putative binding mode of GATPT was constructed by a molecular docking simulation to provide structural insights into the ligand-binding mechanism. Furthermore, we found that this compound can significantly inhibit the dephosphorylation of the extracellular regulated kinases (ERKs), and c-Jun N-terminal kinases (JNKs) and block the G(1)-S phase transition in the cell cycle. Therefore, GATPT is a promising lead structure for designing more effective inhibitors of VHR.     

具有输出网络的有源R滤波器的设计

本文提出具有输出网络的双运放二阶有源R滤波器的综合设计原理.用无源网络的综合方法解决有源网络的综合问题.在实现双二次函数的滤波特性时文中提出的电路具有输出阻抗低的优点.     

Mechanism‐Guided Library Design and Dual Genetic Selection of Synthetic OFF Riboswitches

After the recent discovery of bacterial riboswitches, synthetic riboswitches have been engineered by using natural and artificial RNA aptamers. In contrast to natural riboswitches, the majority of synthetic riboswitches in bacteria reported to date are ON switches that activate gene expression in response to the aptamer ligand. In this study, we adopted a mechanism‐guided approach to design libraries predisposed to contain OFF riboswitches that respond to thiamine pyrophosphate (TPP). The first library design exploited a pseudo‐Shine‐Dalgarno (SD) sequence located near the 3′‐end of the TPP aptamer, which would be less accessible to the ribosome when the aptamer is bound to TPP. In the second library, an SD sequence was strategically placed in the aptamer's P1 stem, which is stabilized upon ligand binding. OFF riboswitches were obtained by dual genetic selection of these libraries. The results underscore the importance of effective library design to achieve desired riboswitch functions.     

基于新型双层组合压边圈的变压边力控制

介绍了一种新型的双层组合压边圈。在无需对常规薄板拉深液压机进行改造的情况下，只需要改变压边圈的结构，即能实现连续、灵活方便地控制实际压边力的分布状态和大小，从而提高大型复杂零件的薄板拉深成形质量。     

去毛刺的两种方法与装置

介绍了精密孔内和双联齿轮或带有拨叉槽齿轮槽中去毛刺的两种方法。经实际使用：简单、可行、效果好。     

双重封闭对建筑用6463铝合金酒石酸氧化膜耐蚀性能的影响

为提高建筑用6463铝合金的耐蚀性能,在6463铝合金表面制备酒石酸氧化膜,然后进行热水-镍盐双重封闭.研究了双重封闭对酒石酸氧化膜的形貌、厚度及耐蚀性能的影响,并与单一热水封闭、镍盐封闭作比较.结果表明:单一封闭和双重封闭对酒石酸氧化膜的厚度基本没有影响,但封闭前后酒石酸氧化膜的形貌、成分及耐蚀性能存在差异.双重封闭...     

球墨铸铁双质量飞轮薄壁铸件铸造工艺优化

介绍了双质量飞轮铸件的结构特点和工艺要求,对铸件夹渣,皱皮,冷隔,缩松等缺陷进行了分析.砂型铸造双质量飞轮铸件先由水平造型生产线生产,后改用DISA垂直造型生产线生产,对熔炼、浇注温度和浇冒口系统进行了工艺改进.应用改进后的工艺生产出了合格的双质量飞轮铸件,提高了成品率.     

Integrated interpretation of dual frequency induced polarization measurement based on wavelet analysis and metal factor methods

In mineral exploration, the apparent resistivity and apparent frequency (or apparent polarizability) parameters of induced polarization method are commonly utilized to describe the induced polarization anomaly. When the target geology structure is significantly complicated, these parameters would fail to reflect the nature of the anomaly source, and wrong conclusions may be obtained. A wavelet approach and a metal factor method were used to comprehensively interpret the induced polarization anomaly of complex geologic bodies in the Adi Bladia mine. Db5 wavelet basis was used to conduct two-scale decomposition and reconstruction, which effectively suppress the noise interference of greenschist facies regional metamorphism and magma intrusion, making energy concentrated and boundary problem unobservable. On the basis of that, the ore-induced anomaly was effectively extracted by the metal factor method.     

分抽混出泵采油工艺技术的改进及应用

针对常规分抽混出泵上泵环形固定阀可靠性差的问题,通过采用桥式通道,改进了流道结构,将上泵固定阀置于下泵下面,实现了上泵的单泵阀结构,提高了分抽泵的可靠性。改进后的分抽泵设计了流道交叉接头,可实现上下泵流道交叉互换,使上下泵对上下层的抽汲互换,从而可以满足多种地质配产需要。针对分抽混出泵整体管柱采用机械坐封造成管柱弯曲、加剧杆管偏磨的问题,配套了丢手插管工艺管柱。改进后的分抽混出泵在河南油田推广应用37井次,平均检泵周期由124 d延长到242 d,平均泵效提高8.8%,累计增油4 322.7 t。