Mechanisms of the FMR1 Repeat Instability: How Does the CGG Sequence Expand?

A dynamic mutation in exon 1 of the FMR1 gene causes Fragile X-related Disorders (FXDs), due to the expansion of an unstable CGG repeat sequence. Based on the CGG sequence size, two types of FMR1 alleles are possible: “premutation” (PM, with 56-200 CGGs) and “full mutation” (FM, with >200 triplets). Premutated females are at risk of transmitting a FM allele that, when methylated, epigenetically silences FMR1 and causes Fragile X syndrome (FXS), a very common form of inherited intellectual disability (ID). Expansions events of the CGG sequence are predominant over contractions and are responsible for meiotic and mitotic instability. The CGG repeat usually includes one or more AGG interspersed triplets that influence allele stability and the risk of transmitting FM to children through maternal meiosis. A unique mechanism responsible for repeat instability has not been identified, but several processes are under investigations using cellular and animal models. The formation of unusual secondary DNA structures at the expanded repeats are likely to occur and contribute to the CGG expansion. This review will focus on the current knowledge about CGG repeat instability addressing the CGG sequence expands.     

人工智能技术课程实践教学改革

根据人工智能技术课程的教学情况,从教学内容、教学方法、教学案例、考核方式、培养实践能力五个方面探讨教学改革.提出在不断更新教学内容和"课堂讲授-课下辅导"模式的基础上,加强网络资源的利用,增加贯穿整个教学过程的分组报告,设计出提高创新能力的教学案例,开展具有多元考核方式以及循序渐进的动态实验设置模式的实践教学改革,以有...     

基础振动下直动式减压阀动态特性分析

针对基础振动对TBM液压元件性能的影响,为TBM液压元件优化设计提供理论依据,选择直动式减压阀为研究对象,分析其工作原理,建立减压阀的动态响应数学模型,仿真研究基础振动幅值和频率对减压阀波动特性的影响规律,分析减压阀不同结构参数对压力波动的影响.结果表明：基础振动会引起减压阀出口压力波动,波动幅值随振动幅值增加而增大;当基础振动频率大于50 Hz时,压力波动幅值随频率的增加明显增大;减小背压腔初始容积和回流通道直径能提高减压阀的动态稳定性.     

油墨与纸张接触的瞬间

油墨的吸收性是印刷质较短的时间尺度上分析油墨与纸张的接触过程,从而建立模型.探讨油墨吸收性对印刷质量的影响,并提出解决办法.     

Research on virtual dynamic optimization design for NC machine tools

Virtual dynamic optimization design can avoid the repeated process from design to trial-manufacture and test. The designer can analyze and optimize the product structures in virtual visualization environment. The design cycle is shortened and the cost is reduced. The paper analyzed the peculiarity of virtual optimization design, and put forwards the thought and flow to implement virtual optimization design. The example to optimize the internal grinder was studied via establishing precise finite element model, modifying the layout of Stiffened Plates and designing parameters of the worktable, and using the technology of modal frequency revision and the technology of multiple tuned damper. The result of optimization design compared the new grinder with the original grinder shows that the entire machine＇s first orders natural frequency is enhanced by 17%, and the response displacement of the grinding-head has dropped by 28% under the first order natural frequency and by 41% under second order natural frequency. Finally, the dynamic performance of the internal grinder was optimized.     

一种改进的ALOHA防碰撞算法

针对现有动态帧时隙ALOHA防碰撞算法在射频识别系统中的标签识别效率最高只能达36.8%的问题,利用标签码元序列的唯一性,改进经典的动态帧时隙ALOHA防碰撞算法中随机选择时隙的方式,提出一种基于标签码元的碰撞序列进行时隙选择的方法,有效降低了标签碰撞的概率,从而提高系统识别效率。仿真结果表明改进的ALOHA标签防碰撞算法识别效率最低为37.5%,随着实际标签数目与碰撞位序列所能确定的标签数目越接近,识别效率越高,最高能达到100%,明显优于现有的动态帧时隙ALOHA算法。     

Constructing Facial Identity Surfaces for Recognition

We present a novel approach to face recognition by constructing facial identity structures across views and over time, referred to as identity surfaces, in a Kernel Discriminant Analysis (KDA) feature space. This approach is aimed at addressing three challenging problems in face recognition: modelling faces across multiple views, extracting non-linear discriminatory features, and recognising faces over time. First, a multi-view face model is designed which can be automatically fitted to face images and sequences to extract the normalised facial texture patterns. This model is capable of dealing with faces with large pose variation. Second, KDA is developed to compute the most significant non-linear basis vectors with the intention of maximising the between-class variance and minimising the within-class variance. We applied KDA to the problem of multi-view face recognition, and a significant improvement has been achieved in reliability and accuracy. Third, identity surfaces are constructed in a pose-parameterised discriminatory feature space. Dynamic face recognition is then performed by matching the object trajectory computed from a video input and model trajectories constructed on the identity surfaces. These two types of trajectories encode the spatio-temporal dynamics of moving faces.     

基于Si8250的数控开关电源环路补偿器设计

以数字电源控制器的设计方法为研究对象,通过建立数控半桥变换器的环路数学模型,利用MathCAD和Matlab来完成环路开环稳定性的运算和分析,采用Venable III型补偿方法设计出数字PID补偿器。环路补偿实验证明,利用Si8250控制器的直接数字控制方案可以达到很好的环路动态响应和稳定特性。     

DSP系统动态电源管理在血流监测仪中的设计与实现

本文介绍了DSP系统动态电源管理在便携式超声多普勒血流监测仪设计中的实现,包括DSP动态频率调整、DSP低功耗模式的应用以及自动关机功能的实现等方面,详细阐述了DSP系统低功耗设计的软、硬件方法。     

IUINet: 基于Shift的双流映射3D医学分割模型

为了提高特征融合, 我们设计了动态全连接层(DyFC), 该方法重新定义了权重和偏置, 使用基向量来代表新的权重和偏置, 基向量的系数是根据每一个输入特征进行学习得到的, 权重和偏置不再是共享的, 而是特有的, 这对于每一个特征的表达更具有专向性. 在本文中, 我们提出了一种双流映射结构模型IUINet. IUINet是通过3DShift操作、空间可分离卷积的组合来实现医学图像分割任务, 同时保持精度和效率之间的平衡. 所提出来的IUINet遵循编码器-解码器结构, 其中编码器一部分包含Shift操作、逐点Conv1×1操作, 另一部分包含空间可分离卷积操作. IUINet运用了多尺度输入以及多尺度特征映射层, 提高反向传播速度, 降低反向传播的平均距离. 提高模型的精确度, 增加模型泛化能力, 减少过拟合.