The far infra-red spectrum of poly(vinyl chloride)

The far infra-red spectrum of a poly(vinyl chloride) sample prepared by the urea clathrate (UC) route has been measured at various temperatures in the range 60 to 320 K. The results, taken in conjunction with those for two less highly ordered polymers, indicate that a revision of the assignments of earlier workers, based on normal coordinate calculations and on the measured spectra of secondary alkyl chlorides such as 2-chlorobutane, is required. The band at 65 cm^?1 is attributed to a lattice mode and is not indicative of weak hydrogen bonds of the type CH…ClC. However, it is suggested that the band at 185 cm^?1, which is particularly clear and sharp with the UC polymer, probably originates from an interaction of this type, occurring specifically at tight chain folds.     

Alcohol-induced changes of {beta}-lactoglobulin - retinol-binding stoichiometry

It has been demonstrated using CD that ethanol induces importantsecondary structure changes of ß-lactoglobulin. CDspectra indicate that ß-lactoglobulin secondary structure,which is mainly composed of ß-strands, becomes mostly-helical under the influence of the solvent polarity changes.The midpoint of ß-strand/-helix transition in ß-lactoglobulinis observed at dielectric constant {small tilde}60 (35% ethanol;v/v). According to CD measurements, the ethanol-dependent secondarystructure changes are reversible. The alkylation of lysines-NH₂ in ß-lactoglobulin weakens the central ß-barrelstructure, since the ß-strand/-helix transition midpointof alkylated ß-lactoglobulin is shifted to lower ethanolconcentration (25% ethanol; v/v). ß-Lactoglobulinstructural changes are triggering the dissociation of the ß-lactoglobulin- retinol complex as judged from complete quenching of its fluorescencein ethanol concentration >30% (v/v). However, in 20% ethanol(v/v), ß-lactoglobulin still retains most of its nativesecondary structure as shown by CD and, in this condition, oneß-lactoglobulin molecule binds an additional secondretinol molecule. This suggests that the highly populated speciesobserved around 20% ethanol (v/v) might represent an intermediatestate able to bind two molecules of retinol.     

The role of heat-shock and chaperone proteins in protein folding: possible molecular mechanisms

Recently some heat-shock proteins have been linked to functionsof ‘chaperoning’ protein folding in vivo. Here currentexperimental evidence is reviewed and possible requirementsfor such an activity are discussed. It is proposed that onemode of chaperone action is to actively unfold misfolded orbadly aggregated proteins to a conformation from whkh they couldrefold spontaneously; that improperly folded proteins are recognizedby excessive stretches of solvent-exposed backbone, rather thanby exposed hydrophobic patches; and that the molecular mechanismfor unfolding is either repeated binding and dissociation (‘plucking’)or translocation of the protein backbone through a binding cleft(‘threading’), allowing the threaded chain to refoldspontaneously. The observed hydrolysis of ATP would providethe energy for active unfolding. These hypotheses can be appliedto both monomeric folding and oligomeric assembly and are sufficientlydetailed to be open to directed experimental verification.     

广西老堡铅锌矿褶皱形成机制及其控矿规律

老堡铅锌矿床主要赋存在陡山沱组白云岩或老堡组硅质岩中,顺层产出,受地层与褶皱的双重控制。矿区主干褶皱为一复式向斜,由2个次级向斜和1个次级背斜组成。从构造几何学、运动学角度,运用现代测试技术,对矿区的小构造、显微构造和组构进行构造分析后揭示,老堡褶皱构造的形成机制是以弯滑作用为主、兼具弯流作用的纵弯褶皱作用的产物。铅锌矿体主要赋存在褶皱的转折端虚脱部位及两翼滑移量较大的层间滑动破碎带中。     

基于指令回收的低功耗循环分支折合技术

在分析循环分支特性的基础上,提出一种基于过期指令回收的高性能低功耗循环分支折合方法.该方法通过复用指令缓冲区硬件资源实现指令回收区.在循环分支折合过程中,循环体指令直接从回收区送入流水线,降低了分支延时,消除了指令高速缓存访问.通过自适应调整回收窗口宽度,可使有限的指令缓冲区硬件资源同时满足指令缓冲与指令回收的双重需求.当投机折合进入预测盲区时关闭分支预测存储器,从而降低投机折合的动态功耗.实验数据表明,与传统循环分支折合技术相比,应用本方法的嵌入式处理器总体性能平均提升5.03%,取指单元动态功耗下降22.10%.     

Bromodomain-like折叠类型模板的设计

针对折叠类型分类中所选天然模板普适性不足的问题,提出了Bromodomain-like折叠类型模板的设计方法.选SCOPe Astral 2.03序列相似度小于40%并且分辨率高于0.25 nm的52个可用Bromodomain-like折叠样本,基于多结构比对结果及数据分析,建立了折叠类型家族模板的设计方法.利用系统聚类方法构建了家族模板的系统聚类图,提出了蛋白质折叠类型模板的设计方法,并用于该折叠类型的模板设计.结果表明：设计模板具有普适性,可用于蛋白质折叠类型分类.     

蛋白质折叠的计算机模拟研究进展

蛋白质折叠是结构生物学领域有待解决的重要科学问题,计算机模拟方法是研究蛋白质折叠的主要手段之一.对蛋白质折叠的计算机模拟研究进展进行了简要介绍,主要内容包括:全原子分子动力学模拟、Gō模型以及弹性网络模型的主要思路及其在蛋白质折叠研究中的应用.     

一种高效的基于服务功能规约的服务选择方法

服务因其灵活的应用机制,逐渐成为软件开发过程中的主要载体.面对网络中涌现出的大量功能相同或相似而QoS(quality of service)不同的服务群体,如何快速、准确地定位到所需要的服务个体,仍是一项十分具有挑战性的工作.基于服务对功能的封装特性,提出一种基于服务功能规约的服务选择方法,将功能相关的抽象服务规约为一个粒度更大的服务级的抽象服务;然后,针对规约后的大粒度抽象服务完成服务发现和组合优化的过程.由于规约操作能够有效减少参与服务组合优化的抽象服务的个数以及相应的候选服务的个数,从而使算法的执行效率得到有效提升.实验结果表明:该算法与传统的启发式算法相比执行效率更高,并且对服务组合规模及候选服务规模表现出更好的扩展性.     

一种基于移动Agent的云端(Cloud-P2P)数据复合销毁机制

云端融合计算(Cloud-P2P)融合了云计算与对等计算环境的所有节点资源,实现了最大范围的协作与资源共享。数据销毁机制是保障用户数据的安全性和可控性的重要措施之一,然而云端计算环境本身的特性也给数据的有效销毁带来了困难。针对云端数据存储系统对数据的主动销毁、定时销毁和自销毁等复合需求,提出一种基于移动Agent的数据复合销毁机制,该方法不依赖第三方,利用移动Agent技术实现对过期、废弃型数据及时、有效、灵活的销毁,并在恶意主体对数据实施攻击时主动实施防御性数据销毁,有效增强了用户数据的安全性。针对节点上数据的具体销毁,还提出一种新颖的“数据折叠”的数据覆写方法,它充分利用数据本身进行销毁,有效降低了系统的开销。     

Repeatedly foldable AMOLED display

In this study, a 5.9‐inch foldable active‐matrix organic light emitting diode (AMOLED) display was developed. A folding test was performed repeatedly. The display survived the folding test (100,000 folds) with a curvature radius of 2 mm. To protect an organic light emitting diode (OLED) against moisture, inorganic passivation layers are provided on the upper and lower sides of the flexible display. Using our transfer technology, high density passivation layers can be obtained. The measured water vapor transmission rate of the layer is 7 × 10^?6 g/m²?day or less, which improves OLED reliability. With these techniques, we have developed a book‐type display, which is repeatedly foldable like a book, and a tri‐fold display including a display area, which is foldable in three.