Nanoporous Copper with Tunable Nanoporosity for SERS Applications

Nanostructured materials with designable microstructure and controllable physical and chemical properties are highly desired for practical applications in nanotechnology. In this article, it is reported that nanoporous copper with a tunable nanopore size can be fabricated by controlling the dealloying process. The influence of acid concentration and etching potential on the formation of nanoprosity is systematically investigated. With optimal etching conditions, the nanopore sizes can be tailored from ～15 to ～120 nm by controlling the dealloying time. It is found that the tunable nanoporosity leads to significant improvements in surface‐enhanced Raman scattering (SERS) of nanoporous copper and peak values of SERS enhancements for both rhodamine 6G and crystal violet 10B molecules are observed at a pore size of ～30–50 nm. This study underscores the effect of complex three‐dimensional nanostructures on physical and chemical properties and is helpful in developing inexpensive SERS substrates for sensitive instrumentations in molecular diagnostics.     

Cancer Cell Membrane‐Coated Gold Nanocages with Hyperthermia‐Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

The cell‐specific targeting drug delivery and controlled release of drug at the cancer cells are still the main challenges for anti‐breast cancer metastasis therapy. Herein, the authors first report a biomimetic drug delivery system composed of doxorubicin (DOX)‐loaded gold nanocages (AuNs) as the inner cores and 4T1 cancer cell membranes (CMVs) as the outer shells (coated surface of DOX‐incorporated AuNs (CDAuNs)). The CDAuNs, perfectly utilizing the natural cancer cell membranes with the homotypic targeting and hyperthermia‐responsive ability to cap the DAuNs with the photothermal property, can realize the selective targeting of the homotypic tumor cells, hyperthermia‐triggered drug release under the near‐infrared laser irradiation, and the combination of chemo/photothermal therapy. The CDAuNs exhibit a stimuli‐release of DOX under the hyperthermia and a high cell‐specific targeting of the 4T1 cells in vitro. Moreover, the excellent combinational therapy with about 98.9% and 98.5% inhibiting rates of the tumor volume and metastatic nodules is observed in the 4T1 orthotopic mammary tumor models. As a result, CDAuNs can be a promising nanodelivery system for the future therapy of breast cancer.     

适合铝丝键合后热老化要求的金导体浆料

研究了一种适合铝丝键合后热老化要求的金导体浆料，性能达到使用要求。在金浆中添加了少量合金元素，并选用混合型粘结剂。对金导体铝丝焊后热老化失效机理以及添加合金元素的作用，进行了讨论     

Gold Nanorods Electrostatically Binding Nucleic Acid Probe for In Vivo MicroRNA Amplified Detection and Photoacoustic Imaging‐Guided Photothermal Therapy

Developing a comprehensive platform which has both diagnosis and therapeutic strategies is necessary for efficient tumor treatment. In this work, a F uel I mproved micro R NA E xplorer (FIRE) probe with signal amplification capability is designed for sensitive detection of microRNA‐21 (miR‐21), which is upregulated in most tumor cells. Besides, FIRE could be loaded by polyethylenimine (PEI)‐modified gold nanorods (AuNR‐PEI) via facile electrostatic interaction, which could avoid the complicated processes commonly used to covalently conjugate nucleic acid probes onto AuNRs. The as‐fabricated AuNR‐PEI/FIRE system could efficiently distinguish tumor cells from non‐tumor cells. The fluorescence signals in MCF‐7 breast carcinoma and HeLa cervical carcinoma cells treated with AuNR‐PEI/FIRE are enhanced 7‐ and 4.5‐fold, respectively, compared with non‐amplification system. AuNR‐PEI/FIRE improves tumor detection ability in vivo and exhibits excellent tumor inhibition efficacy under the fluorescence imaging and photoacoustic imaging guided photothermal therapy. This is the first time to utilize the combined application of amplified nucleic acid detection and photothermal effect derived from gold nanorods together with PA imaging in a facile manner to provide a promising theranostic strategy for accurate diagnosis and tumor therapy.     

柠檬酸金钾无氰沉金厚度控制研究

柠檬酸金钾化学沉镍金工艺是一种新型无氰沉金工艺。利用单因素变化模拟试验及镀层厚度测试研究了该工艺中反应温度、金盐浓度、添加剂浓度、pH值、副产物等因素对无氰沉金工艺的影响,确定金平均沉积速率随各因素变化的关系,为实际生产中沉金厚度控制提供理论依据。     

电镀软金用硫基无氰金配合物电解质研究进展

电镀金工艺中金氰化物([Au(CN)2]-)溶液在过程中会释放出剧毒的游离氰化物离子,严重危害到生产人员和自然环境的健康;此外,它们还会对光刻胶造成一定的破坏.近年来无氰电解质得到了发展.基于对50余篇文献的分析,本文比较了亚硫酸金([Au(SO3)2]3-)、硫代硫酸金([Au(S2O3)2]3-)和二者混合电解液,...     

焙烧预处理过程中硫的转化对浸金的影响

以贵州某卡林型金矿为悁究对象,采用XRD、化恘分析等方法,探索了焙烧预处理过程中焙烧温度、焙烧时间对硫转化率与金浸出率之间相互影响规律。结果表明,在700℃温度下,焙烧1.5~2 h,可以充分打开金的硫化物包裹,浸出率近90%;硫转化率由83.01%升高至91.02%,金浸出率与硫转化率基本呈线性正相关关系,相关系数r=0.93517。     

新疆阿希勒金矿床成矿流体特征

阿希勒金矿床处于额尔齐斯构造成矿带西北段-玛尔卡库里成矿带.通过流体包裹体研究,认为包裹体类型为富CO2的两相包裹体LH2O - LCO2、水溶液两相包裹体(L-V)、纯H2O的单相包裹体.包裹体均-温度值为97.8～298.7℃,盐度为1.81～14.41wt% NaCl.eq,流体密度为0.59～0.83 g/cm...