Pre-Transplant Serum Leptin Levels and Relapse of Acute Myeloid Leukemia after Allogeneic Transplantation

Weight loss and metabolic activity influence outcome after allogeneic stem cell transplantation (alloSCT). This study evaluates pre-conditioning Leptin, a peptide hormone involved in metabolism and immune homeostasis, as a prognostic factor for survival, relapse and non-relapse mortality (NRM) following alloSCT. Leptin serum levels prior to conditioning were determined in a cohort of patients transplanted for various hematologic malignancies (n = 524) and correlated retrospectively with clinical outcome. Findings related to patients with acute leukemia (AL) from this sample were validated in an independent cohort. Low pre-conditioning serum Leptin was an independent prognostic marker for increased risk of relapse (but not of NRM and overall mortality) following alloSCT for AL of intermediate and advanced stage (beyond first complete remission). Multivariate analysis revealed a hazard ratio (HR) for relapse of 0.75 per log2 increase (0.59–0.96, p = 0.020). This effect was similar in an independent validation cohort. Pre-conditioning serum Leptin was validated as a prognostic marker for early relapse by fitting the multivariate Cox model to the validation data. Pre-conditioning serum Leptin levels may serve as an independent prognostic marker for relapse following alloSCT in intermediate and advanced stage AL patients. Prospective studies are required to prove whether serum Leptin could be used for guiding nutritional intervention in patients with AL undergoing alloSCT.     

基于指标验证法的移动用户定量预测方法

针对移动用户发展预测,本文在传统数学预测方法的基础上,提出一种新的指标验证法。该方法充分考虑了指标的控制因素,将ARPU、MOU及资费纳入用户预测的整体考虑,从而达到对移动用户的预测更加合理准确。本文最后以实例验证了该方法的合理性和准确性。     

建设高品质通信电源系统

如何建设高品质通信电源系统,对于保证网络运行起到非常关键的作用。本文通过分析通信系统用电负载类别、负载对电源系统的要求及配制方式进行探讨,提出解决方案。     

水平简谐荷载对深基坑开挖变形的影响

深基坑开挖过程中,由于土体内应力重新分配,导致基坑及周边环境产生变形,影响基坑及周围建筑的安全.论文建立了深开挖条件下基坑变形简化分析模型;采用非线性有限元法,计算了水平简谐荷载作用下支护桩的测向位移、坑底土体隆起量以及地表沉降量,并对深开挖条件下产生的动位移和静位移进行了对比分析,得出了具有工程意义的结论.     

负荷建模的基本原则和方法

回顾了国内外电力系统负荷建模技术的发展以及负荷模型对电力系统计算分析的影响。在基于仿真计算和事故校验的电力负荷校核及调整研究、统计综合法负荷模型软件开发、电力系统负荷特性监测与辨识技术研究3个课题的研究成果基础上,提出了电力系统负荷建模的基本原则与方法。     

实腹式型钢截面压弯构件设计的简化算法

提出一种主要根据内力和计算长度估计型钢截面特性的方法,可提高初选截面的准确性,减少试算次数,从而使实腹式型钢截面压弯构件的计算得到简化,可供工程设计、教学和科研参考。     

Blood Thiol Redox State in Chronic Kidney Disease

Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients with moderate-to-severe chronic kidney disease (CKD) compared to healthy subjects, as well as in end-stage renal disease (ESRD) patients on haemodialysis or peritoneal dialysis. The levels of protein thiols (a measure of the endogenous antioxidant capacity inversely related to protein oxidation) and S-thiolated proteins (mixed disulphides of protein thiols and low molecular mass thiols), and the protein thiolation index (the molar ratio of the S-thiolated proteins to free protein thiols in plasma) have been investigated in the plasma or red blood cells of CKD and ESRD patients as possible biomarkers of oxidative stress. This type of minimally invasive analysis provides valuable information on the redox status of the less-easily accessible tissues and organs, and of the whole organism. This review provides an overview of reversible modifications in protein thiols in the setting of CKD and renal replacement therapy. The evidence suggests that protein thiols, S-thiolated proteins, and the protein thiolation index are promising biomarkers of reversible oxidative stress that could be included in the routine monitoring of CKD and ESRD patients.     

柳钢中板轧机工作辊的选择和使用

本文对比分析了轧辊的类型、硬度及技术经济指标,确定了工作轧辊的选择依据,并对生产中出现的实际问题提出了相应的措施。     

区间模型非概率可靠性指标的一维优化算法

证明了基于区间模型的非概率可靠性指标只可能存在于:标准化区间向量张成的凸域及其扩展空间中,通过原点和凸域顶点的有限条超射线与标准化失效面的某个交点处,从而极大地缩小了优化方法求取非概率可靠性指标的可行域,使放弃计算结果极易扩张的区间运算法则和计算量太大的高维寻优方法成为可能。提出了求取非概率可靠性指标的一维优化方法,讨论了一维优化方法搜索区间关于0对称且具有半径递减的特性,利用该特性明显提高一维优化算法的效率。     

大客户电力负荷管理系统自动检测技术的研究

基于GPRS和CDMA无线公网技术的新一代大客户负荷管理终端和通信前置机是构建大客户负荷管理系统的关键.对终端检测采用自动检测技术,不仅大大提高了测试的速度和准确性,同时利用统一的测试基准平台,有效保证了不同厂商终端和前置机功能的一致性和兼容性,为建立开放系统,实现不同厂商间系统和终端产品的互连、互通、互换,以及营造公平竞争环境提供了基本保证.