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排序方式: 共有1392条查询结果,搜索用时 15 毫秒
31.
Alaa Fehaid 《Science and Technology of Advanced Materials》2018,19(1):526-534
Silver nanoparticles (AgNPs) are widely known to have anti-inflammatory properties, but the exact mechanism underlying this anti-inflammatory effect is not clearly understood. Tumor necrosis factor-α (TNFα) is a major pro-inflammatory cytokine that is expressed in the early stage of cell inflammation and induces apoptosis by several known pathways. Our study aimed to investigate the effect of AgNPs on the response of lung epithelial cells to TNFα and the molecular mechanism of this response. Lung epithelial cell line NCI-H292 cells were exposed to AgNPs (5 µg/mL) and/or TNFα (20 ng/mL) for 24 h, then cellular uptake was analyzed using flow cytometry. Our results showed that AgNPs were taken up by cells in a dose-dependent manner and that the cellular uptake ratio of AgNPs was significantly increased in the presence of TNFα. Apoptosis assays indicated that exposure to AgNPs significantly decreased the apoptotic effect of TNFα. Confocal microscopy was used to localize the tumor necrosis factor receptor 1 (TNFR1) and revealed that TNFR1 localized on the surface of cells exposed to TNFα. In contrast, TNFR1 localized inside cells exposed to both AgNPs and TNFα, with very few receptors scattered on the cell membrane. The results indicated that AgNPs reduced the cell surface TNFR1 expression level. The results suggested that the reduction of surface TNFR1 reduced cellular response to TNFα, resulting in an anti-apoptotic effect. 相似文献
32.
The extent of the peril associated with cancer can be perceived from the lack of treatment, ineffective early diagnosis techniques, and most importantly its fatality rate. Globally, cancer is the second leading cause of death and among over a hundred types of cancer; lung cancer is the second most common type of cancer as well as the leading cause of cancer-related deaths. Anyhow, an accurate lung cancer diagnosis in a timely manner can elevate the likelihood of survival by a noticeable margin and medical imaging is a prevalent manner of cancer diagnosis since it is easily accessible to people around the globe. Nonetheless, this is not eminently efficacious considering human inspection of medical images can yield a high false positive rate. Ineffective and inefficient diagnosis is a crucial reason for such a high mortality rate for this malady. However, the conspicuous advancements in deep learning and artificial intelligence have stimulated the development of exceedingly precise diagnosis systems. The development and performance of these systems rely prominently on the data that is used to train these systems. A standard problem witnessed in publicly available medical image datasets is the severe imbalance of data between different classes. This grave imbalance of data can make a deep learning model biased towards the dominant class and unable to generalize. This study aims to present an end-to-end convolutional neural network that can accurately differentiate lung nodules from non-nodules and reduce the false positive rate to a bare minimum. To tackle the problem of data imbalance, we oversampled the data by transforming available images in the minority class. The average false positive rate in the proposed method is a mere 1.5 percent. However, the average false negative rate is 31.76 percent. The proposed neural network has 68.66 percent sensitivity and 98.42 percent specificity. 相似文献
33.
34.
Michalis Savelonas Dimitris Maroulis Manolis Sangriotis 《Computer methods and programs in biomedicine》2009,96(1):25-32
In this paper, a novel computer-based approach is proposed for malignancy risk assessment of thyroid nodules in ultrasound images. The proposed approach is based on boundary features and is motivated by the correlation which has been addressed in medical literature between nodule boundary irregularity and malignancy risk. In addition, local echogenicity variance is utilized so as to incorporate information associated with local echogenicity distribution within nodule boundary neighborhood. Such information is valuable for the discrimination of high-risk nodules with blurred boundaries from medium-risk nodules with regular boundaries. Analysis of variance is performed, indicating that each boundary feature under study provides statistically significant information for the discrimination of thyroid nodules in ultrasound images, in terms of malignancy risk. k-nearest neighbor and support vector machine classifiers are employed for the classification tasks, utilizing feature vectors derived from all combinations of features under study. The classification results are evaluated with the use of the receiver operating characteristic. It is derived that the proposed approach is capable of discriminating between medium-risk and high-risk nodules, obtaining an area under curve, which reaches 0.95. 相似文献
35.
Erick Corrêa da Silva Aristófanes Corrêa Silva Anselmo Cardoso de Paiva Rodolfo Acatauassu Nunes 《Pattern Analysis & Applications》2008,11(1):89-99
This paper analyzes the application of Moran’s index and Geary’s coefficient to the characterization of lung nodules as malignant
or benign in computerized tomography images. The characterization method is based on a process that verifies which combination
of measures, from the proposed measures, has been best able to discriminate between the benign and malignant nodules using
stepwise discriminant analysis. Then, a linear discriminant analysis procedure was performed using the selected features to
evaluate the ability of these in predicting the classification for each nodule. In order to verify this application we also
describe tests that were carried out using a sample of 36 nodules: 29 benign and 7 malignant. A leave-one-out procedure was
used to provide a less biased estimate of the linear discriminator’s performance. The two analyzed functions and its combinations
have provided above 90% of accuracy and a value area under receiver operation characteristic (ROC) curve above 0.85, that
indicates a promising potential to be used as nodules signature measures. The preliminary results of this approach are very
encouraging in characterizing nodules using the two functions presented.
相似文献
Rodolfo Acatauassu NunesEmail: |
36.
Scanning electron microscopic observations were made on the micro-organisms of root nodules of Tribulus terrestris L. The results showed that nodules of T. terrestris contained dual infection consisting of Rhizobium sp. and Newmania karachiensis. Based on these observations, T. terrestris should be grouped with nonlegume Parasponia-type bacterial nodules. 相似文献
37.
蛙皮素受体亚型-3(BRS-3)属G蛋白偶联受体,至今未发现天然配体。BRS-3具有广泛的生物学作用,可调控神经内分泌功能、能量代谢及细胞生长增殖。在啮齿类动物及哺乳动物体内都有分布,大多数组织表达水平很低(包括正常肺组织),但在某些肺部疾病及胎肺中表达增加。就BRS-3受体特点、激活后信号转导机制及其与肺肿瘤、肺发育、慢性炎症性肺病的联系作一综述。 相似文献
38.
张贺 《辽东学院学报(自然科学版)》2013,(4):247-252
通过观察大气污染物引起大鼠肺损伤的病理组织学变化,分析肺组织内血红素氧合酶1(HO-1)的表达量的变化,为大气污染所致肺损伤的生物学标记物的研究提供科学依据。实验方法如下:将30只Wistar大鼠,随机分为3个实验组(3d、7d、30d组)和3个对照组(3d、7d、30d组),对实验组大鼠染尘染毒后提取所有大鼠肺组织,观察其病理组织学变化;RT-PCR技术检测各组肺组织中HO-1的mRNA表达;Western-blot技术检测各组肺组织中HO-1蛋白的表达。结果显示:实验组(7d及30d)的肺组织病理形态学评分显著高于对照组(7d及30d),实验组(7d及30d)大鼠肺组织HO-1mRNA表达与对照组相比,具有显著性差异(P均〈0.05)。随着吸入大气混合污染物的时间延长,肺组织内的HO-1蛋白表达水平逐渐增高,实验组(7d及30d)与对照组(7d及30d)相比,差异有显著性意义(P〈0.05)。在吸入大气混合污染物后早期(7d),HO-1转录水平升高。持续吸入混合大气污染物(30d),大鼠肺组织出现明显的病理组织学变化,HO-1转录水平、蛋白表达水平均比对照组明显升高。得出结论:可将HO-1作为大气混合污染物所致的肺损伤的早期生物学标记物;采取某些手段增加肺组织HO-1的表达,可能会减少混合大气污染物对肺组织造成的损伤。 相似文献
39.
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