基于多幅图像的有效点扩散函数的高精度测量

将图像融合以及高精度测量方法应用于天文图像处理,对图片进行处理得到有效点扩散函数,并将有效点扩散函数拟合星像,得到星体的位置与光度信息．结果表明, 方向平均定位精度为0．036 pixel,Y方向平均定位精度为0．O44 pixel,平均测光精度达到0．032 magnitude,测量结果验证了该算法的有效性．     

D-S证据融合的中医辨证模型

为提高传统不确定性推理在中医辨证中的准确率和灵活性,提出了基于D-S证据理论的中医辨证模型。模型采用群决策理论,以证素为识别框架,以不同专家的诊断结果为基本可信度分配,对专家的诊断结果进行证据融合,模型能够降低系统的不确定性,提高证素诊断的准确率和可信度。以冠心病的中医诊断为例,验证了模型的有效性。     

Reduced VDAC1, Maintained Mitochondrial Dynamics and Enhanced Mitochondrial Biogenesis in a Transgenic Tau Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is one of the most common forms of neurodegeneration, defined by reduced cognitive function, which is caused by the gradual death of neurons in the brain. Recent studies have shown an age-dependent rise in the levels of voltage-dependent anion channel 1 (VDAC1) in AD. In addition, we discovered an aberrant interaction between VDAC1 and P-TAU in the brains of AD patients, which led to abnormalities in the structural and functional integrity of the mitochondria. The purpose of our study is to understand the protective effects of reduced VDAC1 against impaired mitochondrial dynamics and defective mitochondrial biogenesis in transgenic TAU mice. Recently, we crossed heterozygote VDAC1 knockout (VDAC1^+/−) mice with transgenic TAU mice to obtain double-mutant VDAC1^+/−/TAU mice. Our goal was to evaluate whether a partial decrease in VDAC1 lessens the amount of mitochondrial toxicity in transgenic Tau (P301L) mice. We found that mitochondrial fission proteins were significantly reduced, and mitochondrial fusion and biogenesis proteins were increased in double-mutant mice compared to TAU mice. On the basis of these discoveries, the current work may have significance for the development of reduced-VDAC1-based treatments for individuals suffering from AD as well as other tauopathies.     

用数据挖掘技术分析融合系统的性能

使用数据挖掘技术对融合系统性能测试结果进行分析 ,以便找出影响融合性能的因素 ,发现各种影响因子间的相互关系 ,通过调整不利因素 ,改进设计方法 ,进一步提高了融合系统的性能     

音素关联的多文种语音融合编码方法

依据异类文种之间、同类文种不同语音之间存在音素数据关联的特性,提出多文种语音数据融合编码方法。将不同文种存在的相同音素数据段块按段块模板截取语音样本序列,小波变换,提取特征矢量,生成共享模板集;任意字音或语句音串均按共享模板集提供的元素进行编码与解码;以模板音素串构成的语音记录库按（音节、音素）索引。实验结果表明,单字语音数据压缩比、语音数据存储量、语音还原分段信噪比、主观评价得分等参数均明显优于已有方法,语音还原质量良好。     

多传感器信息融合技术探析

多传感器信息融合是一门涉及信号处理、信息论、人工智能、模糊数学等理论的多学科交叉技术,被广泛应用于军事和民用领域。文章介绍了多传感器信息融合的概念,描述了多传感器信息融合的功能模型、主要方法和应用,并对其发展趋势进行了分析。     

Attraction and Repulsion of Nucleons: Sources of Stellar Energy

The potential energy of a nuclide is enhanced by about 10 MeV per nucleon from the repulsion between like nucleons, and diminished by about 20 MeV per nucleon from the attraction between unlike nucleons. Nuclear stability results mostly from the interplay of these opposing forces, plus Coulomb repulsion of positive charges. Whereas fusion may be the primary mechanism by which first generation stars produce energy, repulsion between like nucleons may cause neutron emission from the collapsed core (neutron star) produced in a terminal supernova explosion and initiate luminosity in second generation stars that accrete on such objects. As noted earlier [1], the scarcity of solar neutrinos, the enrichment of light isotopes in the solar wind, and the presence of abundant short-lived nuclides and interlinked chemical and isotopic heterogeneities in the early solar system might also be explained if the Sun formed in this manner.     

基于双CPU技术的泵和马达控制系统的研究与设计

为获取泵和马达的静态与动态特性,设计了基于ADμC812和TMS320F206的双CPU结构的多传感器融合与控制系统。介绍了该系统的体系结构、硬件配置、接口电路、工作原理和工作流程。实现了传感器信息融合的高速高精度采集、复杂算法的大数据量实时计算以及模拟与开关量并有的多通道控制等功能,系统硬件结构简单。该系统作为泵、马达综合试验台的子系统,用于泵、马达性能试验。应用表明该系统能够满足试验要求,具有很好的可靠性和实时性。     

Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly

Vimentin, a type III intermediate filament protein, is found in most cells along with microfilaments and microtubules. It has been shown that the head domain folds back to associate with the rod domain and this association is essential for filament assembly. The N-terminally tagged vimentin has been widely used to label the cytoskeleton in live cell imaging. Although there is previous evidence that EGFP tagged vimentin fails to form filaments but is able to integrate into a pre-existing network, no study has systematically investigated or established a molecular basis for this observation. To determine whether a tag would affect de novo filament assembly, we used vimentin fused at the N-terminus with two different sized tags, AcGFP (239 residues, 27 kDa) and 3 × FLAG (22 residues; 2.4 kDa) to assemble into filaments in two vimentin-deficient epithelial cells, MCF-7 and A431. We showed that regardless of tag size, N-terminally tagged vimentin aggregated into globules with a significant proportion co-aligning with β-catenin at cell–cell junctions. However, the tagged vimentin aggregates could form filaments upon adding untagged vimentin at a ratio of 1:1 or when introduced into cells containing pre-existing filaments. The resultant filament network containing a mixture of tagged and untagged vimentin was less stable compared to that formed by only untagged vimentin. The data suggest that placing a tag at the N-terminus may create steric hinderance in case of a large tag (AcGFP) or electrostatic repulsion in case of highly charged tag (3 × FLAG) perhaps inducing a conformational change, which deleteriously affects the association between head and rod domains. Taken together our results shows that a free N-terminus is essential for filament assembly as N-terminally tagged vimentin is not only incapable of forming filaments, but it also destabilises when integrated into a pre-existing network.