The development of a high-speed spindle measurement system using a laser diode and a quadrants sensor

Reducing the manufacturing time is the trend of precision manufacturing, and the precision of a work-piece is very important for manufacturing industry. High-speed cutting is becoming more widely used and the high-speed spindle is a very important element, whose precision may affect the overall performance of high-speed cutting. Most of the studies on high-speed cutting are focused on the cutting force, the vibration of the spindle and the effects of the spindle's thermal expansion; however, the measurement of the high-speed spindle continues to use the conventional spindle measurement method.As with the measurement of the high-speed spindle, more strict demands are set on the dynamic balance of cutting tools and the bandwidth of the measurement systems when compared with common spindles. The capacitance displacement sensor has been employed for the spindle error test. The precision of the measurement system is limited by the reference (such as a master ball or a master cylinder). Also the capacitance sensor and the reference must be grounded together. This paper presents a simple spindle measurement system using a laser diode and a quadrants sensor, with accuracy up to 1 μm, within 300,000 rpm for various spindles. The system does not need any reference and it is easy to set up. This system can be applied to measure the spindle errors, the spindle speed and the spindle indexing.     

Human Milk Antibodies against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with a Confirmed COVID-19 PCR,Viral SYMPTOMS,and Unexposed Mothers

Background: Preexisting immunity to SARS-CoV-2 could be related to cross-reactive antibodies to common human-coronaviruses (HCoVs). This study aimed to evaluate whether human milk antibodies against to S1 and S2 subunits SARS-CoV-2 are cross-reactive to S1 and S2 subunits HCoV-OC43 and HCoV-229E in mothers with a confirmed COVID-19 PCR test, in mothers with previous viral symptoms during COVID-19 pandemic, and in unexposed mothers; Methods: The levels of secretory IgA (SIgA)/IgA, secretory IgM (SIgM)/IgM, and IgG specific to S1 and S2 SARS-CoV-2, and reactive to S1 + S2 HCoV-OC43, and HCoV-229E were measured in milk from 7 mothers with a confirmed COVID-19 PCR test, 20 mothers with viral symptoms, and unexposed mothers (6 Ctl1-2018 and 16 Ctl2-2018) using ELISA; Results: The S2 SARS-CoV-2 IgG levels were higher in the COVID-19 PCR (p = 0.014) and viral symptom (p = 0.040) groups than in the Ctl1-2018 group. We detected a higher number of positive correlations between the antigens and secretory antibodies in the COVID-19 PCR group than in the viral symptom and Ctl-2018 groups. S1 + S2 HCoV-OC43-reactive IgG was higher in the COVID-19 group than in the control group (p = 0.002) but did not differ for the other antibodies; Conclusions: Mothers with a confirmed COVID-19 PCR and mothers with previous viral symptoms had preexisting human milk antibodies against S2 subunit SARS-CoV-2. Human milk IgG were more specific to S2 subunit SARS-CoV-2 than other antibodies, whereas SIgA and SIgM were polyreactive and cross-reactive to S1 or S2 subunit SARS-CoV-2.     

无线传感器网络移动Sink网关系统的设计与实现*

针对无线传感器网络传统Sink网关的不足,提出了一种基于PDA的移动Sink网关系统的设计与实现方案,对其设计目标、体系结构和工作原理进行了论述,重点讨论了PDA与Sink节点之间的连接,PDA与Sink节点、PDA与GPS接收机及PDA与控制终端之间通信的一些关键技术.     

Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA

Reactive intermediate deaminase (Rid) proteins are enzymes conserved in all domains of life. UK114, a mammalian member of RidA subfamily, has been firstly identified as a component of liver perchloric acid-soluble proteins (L-PSP). Although still poorly defined, several functions have been attributed to the mammalian protein UK114/RIDA, including the reactive intermediate deamination activity. The expression of UK114/RIDA has been observed in some tumors, arousing interest in this protein as an evaluable tumor marker. However, other studies reported a negative correlation between UK114/RIDA expression, tumor differentiation degree and cell proliferation. This work addressed the question of UK114/RIDA expression in human non-tumor HEK293 cell lines and in some human tumor cell lines. Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation. In HEK293, hRIDA K-succinylation was negatively correlated to the cell proliferation rate and was under the control of SIRT5. Moreover, K-succinylation clearly altered hRIDA quantification by immunoblotting, explaining, at least in part, some discrepancies about RIDA expression reported in previous studies. We found that hRIDA was able to deaminate reactive enamine-imine intermediates and that K-succinylation drastically reduced deaminase activity. As predicted by in silico analysis, the observed reduction of deaminase activity has been related to the drastic alterations of hRIDA structure inferred by K-succinylation. The role of hRIDA and the importance of its K-succinylation in cell metabolism, especially in cancer biology, have been discussed.     

非晶金属丝的电磁性能及其在传感技术中的应用

非晶金属丝具有高的机械强度和优异的电磁特性。利用这些性能，可以用它制作各种传感器件。尤其，Ｆｅ基非晶丝存在大的巴克豪森和迈悌欧斯效应，是无颤动尖锐脉冲电动势发生器件材料。Ｃｏ－Ｆｅ基非晶丝具有零磁致伸缩效应。两类非晶金属丝主要被应用到制作传感器方面。非晶金属丝以它的圆截面形状，可高度集成的优点正在引进电子仪表进行的兴趣。     

高技术产品用无源元件与中国钽工业发展

世界高技术产品市场总体看呈增长趋势，预计2020年销售额将比2000年翻一番。以高技术产品为主要应用领域的电阻、电容、电感等无源元件，也将随着高技术产业的发展呈现出良好的市场前景，但是钽电容器市场近几年表现出骤涨急落的发展态势。由于钽电容器产能过剩，且面临着被替代的威协，因此价格将无法返回到2000年以前的水平，并呈现整体持续走低的趋势。中国的钽工业发展应注重提高企业自身的综合竞争力，加强企业间的沟通、交流与合作，维护我国钽工业的整体利益，增强环保意识，做好国外转移到我国的初级产品和低端产品生产的环保工作。     

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 传感器采用的28 μm厚的4层结构PVDF压电薄膜制成，传感器表面电极形状的制作采用剪切加丙酮腐蚀的方法，保证了传感器有一定的非金属化的边缘。对于电极的引出是将传感器上、下电极面引脚错开，引出电极比较容易做到穿透式，采用压接端子压接和空心小铆钉铆接两种方法。     

软测量建模方法分析

介绍软测量技术的基本原理，论述了工业过程控制中常用的六种软测量建模方法及其优缺点，指出软测量技术与其它技术相结合，将会取得更广泛的应用。     

Humidity Sensor Characteristics of Woodceramics

The humidity sensor characteristics of Woodceramics were investigated. The Woodceramics used in this experiment were prepared at 650–900°C. The size of specimens selected was 1 × 1 × 10 mm . One was used as-cut and the other was polished. Above 700°C, the resistance of the specimen was below 50 and the decrease of resistance with increasing relative humidity was small. The specimen prepared at 650°C had a resistance of about 1 k. The resistance of as-cut specimens decreased with increase in relative humidity, but that of the polished specimen did not change significantly. The difference between as-cut and polished samples was explained by the differences in surface micro-structure.     

A carboxyalkanethiol monolayer modified electrode for blocking of ascorbic acid oxidation and its application to a biosensor

Upon the application of amperometric biosensor to the biological fluid, ascorbic acid interferes the amperometric determination of analytes, because the oxidative potential of ascorbic acid is lower than that of electro active substances such as H₂O₂ produced by the enzymatic reaction. In this study we propose a method to block ascorbic acid based on the electrostatic interaction with self-assembled monolayer (SAM) and its application of the surface modified electrode to biosensor. In order to form SAM on the gold electrode with carboxyl group, 7-carboxy-heptanethiol (7-CHT) was used. The 7-CHT modified electrode did not show anodic response to ascorbic acid, but oxidized phenanthroline cobalt complex [Co(phen)₃²⁺], which can be used as a mediator of biosensor. Thus, the 7CHT-modified electrode was applied to biosensor mediated with Co(phen)₃²⁺. Fructose dehydrogenase (FDH) was immobilized to the 7-CHT modified electrode. Fructose was determined selectively with the FDH/7-CHT modified electrode at the range of 0.2-2 mM.