Age-Dependent Control of Collagen-Dependent Platelet Responses by Thrombospondin-1—Comparative Analysis of Platelets from Neonates,Children, Adolescents,and Adults

Platelet function is developmentally regulated. Healthy neonates do not spontaneously bleed, but their platelets are hypo-reactive to several agonists. The mechanisms underlying immature platelet function in neonates are incompletely understood. This critical issue remains challenging for the establishment of age-specific reference ranges. In this study, we evaluated platelet reactivity of five pediatric age categories, ranging from healthy full-term neonates up to adolescents (11–18 years) in comparison to healthy adults (>18 years) by flow cytometry. We confirmed that platelet hypo-reactivity detected by fibrinogen binding, P-selectin, and CD63 surface expression was most pronounced in neonates compared to other pediatric age groups. However, maturation of platelet responsiveness varied with age, agonist, and activation marker. In contrast to TRAP and ADP, collagen-induced platelet activation was nearly absent in neonates. Granule secretion markedly remained impaired at least up to 10 years of age compared to adults. We show for the first time that neonatal platelets are deficient in thrombospondin-1, and exogenous platelet-derived thrombospondin-1 allows platelet responsiveness to collagen. Platelets from all pediatric age groups normally responded to the C-terminal thrombospondin-1 peptide RFYVVMWK. Thus, thrombospondin-1 deficiency of neonatal platelets might contribute to the relatively impaired response to collagen, and platelet-derived thrombospondin-1 may control distinct collagen-induced platelet responses.     

Temperature Dependence of Permeability of Co66Fe4Mo2Si16B12 Alloy

At different annealing temperatures, the saturation magnetostrictions and the correlation between the permeability μi and the temperature T (μi-T curves) of the Co66Fe4Mo2Si16B12 alloy were investigated using a small-angle magnetization tester and core tester. The experimental results showed that the μi-T curves had different shapes at different ranges of annealing temperature;the permeability μi of the alloy improved with the increase of the annealing temperatures below 460℃; when the alloy was annealed above 480℃, the poor magnetic properties were considered to be caused by larger saturation magnetostriction.     

The LR-Chart: An Alternative to the MR-Chart

An individuals chart is proposed in which the mean level is estimated using the regression smoother LOWESS, and deviations from this mean estimate are plotted. This LOWESS-range (LR) chart yields an estimator of the process variance from stable measurements, which is almost as efficient as the estimator based on the sample standard deviation. The estimator often has lower mean squared-error than a moving-range-based estimator when applied to mean-shifted measurements.     

交-交变频器双变量控制理论的新拓展

本文介绍了双变量控制理论,对频段的结合作了进一步的研究,给出了3分频以下频段结合的经验公式,并对频率为25Hz以上的调速进行了磁势分析和谐波分析,均给出了实验数据。     

基于空间仿射对应点列的双曲抛物面三维构建及分析

利用计算机3D软件构建基于空间仿射对应点列的双曲抛物面。对双曲抛物面进行不同方向的投射,可以准确得到双曲抛物面不同方位和角度的投影图。从这些投影图中,可以更直观、清楚的了解双曲抛物面的投影特点。使用多个不同位置的平面对双曲抛物面进行截切,并通过分析、观察截交线的变化趋势,得出几点规律性的结论。     

双摇块五连杆机构

本文论述了双摇块五连杆机构 ,分析了双摇杆五连杆机构的正解和逆解 ,分析了双摇杆五连机构的运动范围。     

水工混凝土28d龄期强度控制范围确定方法探讨

为提高西南某大型水电站混凝土生产质量控制水平,加强混凝土生产质量管理,探讨了水工长龄期混凝土28 d龄期立方体抗压强度标准值及其立方体抗压强度建议控制范围的确定方法,提出了28 d龄期立方体抗压强度标准值和建议控制范围的计算公式,并结合工程应用实例对提出的计算确定方法进行了验证,验证结果能较好地指导水工混凝土生产质量控制。     

Frequency-range discriminations and absolute pitch in black-capped chickadees (Poecile atricapillus), mountain chickadees (Poecile gambeli), and zebra finches (Taeniopygia guttata).

The acoustic frequency ranges in birdsongs provide important absolute pitch cues for the recognition of conspecifics. Black-capped chickadees (Poecile atricapillus), mountain chickadees (Poecile gambeli), and zebra finches (Taeniopygia guttata) were trained to sort tones contiguous in frequency into 8 ranges on the basis of associations between response to the tones in each range and reward. All 3 species acquired accurate frequency-range discriminations, but zebra finches acquired the discrimination in fewer trials and to a higher standard than black-capped or mountain chickadees, which did not differ appreciably in the discrimination. Chickadees' relatively poorer accuracy was traced to poorer discrimination of tones in the higher frequency ranges. During transfer tests, the discrimination generalized to novel tones when the training tones were included, but not when they were omitted. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

联合数值域的凸性

本文研究了交换算子组的联合数值域的凸性;特别地,我们对重交换亚正规算子组性形证明了Toeplitz-Hausdorff 定理.     

Thermal comfort in residential buildings: Comfort values and scales for building energy simulation

Building Energy Simulation (BES) programmes often use conventional thermal comfort theories to make decisions, whilst recent research in the field of thermal comfort clearly shows that important effects are not incorporated. The conventional theories of thermal comfort were set up based on steady state laboratory experiments. This, however, is not representing the real situation in buildings, especially not when focusing on residential buildings. Therefore, in present analysis, recent reviews and adaptations are considered to extract acceptable temperature ranges and comfort scales. They will be defined in an algorithm, easily implementable in any BES code. The focus is on comfortable temperature levels in the room, more than on the detailed temperature distribution within that room.