PROCESS CONTROL PERSPECTIVE FOR PROCESS ANALYTICAL TECHNOLOGY: INTEGRATION OF CHEMICAL ENGINEERING PRACTICE INTO SEMICONDUCTOR AND PHARMACEUTICAL INDUSTRIES

FDA's Process Analytical Technology (PAT) initiative provides an unprecedented opportunity for chemical engineers to play significant roles in the pharmaceutical industry. In this article, the authors provide their perspectives on (1) the need for chemical engineering principles in pharmaceutical development for a thorough process understanding; (2) applications of chemical engineering principles to meet the challenges from the semiconductor and pharmaceutical industries; and (3) the integration of chemical engineering practice into the semiconductor and pharmaceutical industries to achieve process understanding and the desired state of quality-by-design. A real-world case study from the semiconductor industry is presented to demonstrate how a classic chemical engineering concept, mixing homogeneity, can be implemented by inducing forced flow to ensure an excellent copper electrochemical plating process performance and to improve product quality substantially. Further, a case study of brake system design is discussed with the concept of Dr. Taguchi's robust engineering design to illustrate how quality-by-design can be achieved through appropriate experimental design, in conjunction with the discussion on the concept of quality-by-design in pharmaceuticals. Third, a case study of freeze-dried sodium ethacrynate is presented to demonstrate the vital importance of controlling the processing factors to achieve the desired product stability. Finally, the problems of the current pharmaceutical manufacturing mode, the opportunities and engineering challenges during implementation of PAT in the pharmaceutical industry, and the role of chemical engineering in implementation of PAT is discussed in detail.     

混合H2／H∞控制问题的降阶控制器

考虑混合H2／H∞控制问题的降阶控制器的设计问题．基于线性矩阵不等式（LMI）,分别‘给出了连续和离散情形下混合H2／H∞问题的降阶控制器的设计．     

Robust parametric approach for tracking control of an air-breathing hypersonic cruise vehicle

To realize the stabilization and the tracking of flight control for an air-breathing hypersonic cruise vehicle, the linearization of the longitudinal model under trimmed cruise condition is processed firstly. Furthermore, the flight control problem is formulated as a robust model tracking control problem. And then, based on the robust parametric approach, eigenstructure assignment and reference model tracking theory, a parametric optimization method for robust controller design is presented. The simulation results show the effectiveness of the proposed approach.     

一类离散Markov跳跃系统基于状态观测器的鲁棒H_∞控制

研究了具有不确定性的模式依赖时滞离散Markov跳跃系统基于状态观测器的鲁棒H∞控制问题。目的是构建依赖于系统模式的观测器和控制器,使得闭环系统是随机稳定的且具有较好的H∞干扰抑制性能。通过选取合适的随机Lyapunov函数,利用线性矩阵不等式,给出了鲁棒H∞控制器存在的时滞依赖条件。基于锥补线性化算法对控制器进行求解,得到了模式依赖观测器和控制器。最后通过数值仿真证明了本文方法的可行性。     

基于小波神经网络补偿的飞艇滑模控制

平流层飞艇具有非线性、参数慢时变等特征,在滞空期间,还受到阵风及大气紊流的影响．将反推滑模技术用于实现飞艇姿态的鲁棒控制,保证了系统稳定．为避免变结构控制中固有的抖振现象,使用自回归小波神经网络（Self—RecurrentWaveletNeuralNetworks,SR—WNN）实时调整开关增益的大小,网络的自回归单元可以克11~,J、波函数的振荡特性,使得估计更为平滑．仿真结果表明：控制器能够适应飞艇结构参数变化及外部扰动的影响,获得强的鲁棒性与好的动态性能．     

不确定性线性系统的H_∞输出反馈鲁棒重复控制

为了抑制乘性不确定性线性系统中的外部扰动,提出了一种重复控制器与输出反馈控制器参数同时优化的方法.引入一个假想摄动将系统的扰动抑制问题归结为具有结构型摄动的系统鲁棒稳定性问题.根据小增益定理得到该结构型摄动系统鲁棒稳定性的充分条件.引入一个稳定的定标阵,得到该结构型摄动系统低保守性的鲁棒稳定性充分条件.基于该充分条件和线性矩阵不等式方法(LMI)、锥补线性化方法(CCL),提出的迭代算法可以同时计算出重复控制器中低通滤波器剪切频率的最大值及其对应的输出反馈控制器的参数.最后,低频线振动台系统验证了该方法的有效性。     

超空泡航行体纵向运动的鲁棒极点配置控制

由于空泡及滑行力的存在,使得超空泡航行体的建模及控制问题变得非常复杂,在其模型简化过程中会产生一定的建模误差,采用鲁棒极点配置算法进行超空泡航行体控制可以有效克服这一缺点.对超空泡航行体所受的流体动力、尤其是滑行力的动态特性进行了分析整理;建立了超空泡航行体纵平面内的动力学模型;最后利用鲁棒极点配置算法设计了控制器.仿真结果表明,该控制系统具有较强的鲁棒性及稳定性.对各控制变量的控制效果进行了对比分析,分析结果表明空化器比尾舵具有更好的控制效果.     

基于DDWT的复合型数字图像水印算法

提出了一种鲁棒性数字水印和脆弱性数字水印相结合的复合式水印算法,具有较好的双重保护性能,即用于版权认证方面的鲁棒性数字水印和用于图像内容保护的脆弱性数字水印.首先,对原始图像进行DDWT和SVD变换在频域中嵌入鲁棒性数字水印;然后,在空域中嵌入脆弱性数字水印.仿真实验表明,该算法具有很好的应用前景.     

像素聚类改进二进制描述子鲁棒性

目标：本文通过挖掘图像局部区域特征信息,提出了一种鲁棒性更高的二进制描述子。针对BRIEF关于旋转和视角变化鲁棒性差的问题,本文通过图像补丁分层处理、增加关键点图像补丁个数来捕获更多的局部特征信息,对BRIEF描述子改进。方法：首先,根据灰度序列对补丁内所有像素点分类,像素的一个聚类形成了一个亚补丁,然后在每个亚图像补丁上进行类似BRIEF的随机测试。其次,由于原图像补丁大小、尺度大小影响补丁的像素点成分,从而影响像素聚类的效果,所以在原图像关键点周围分割出多个不同大小的图像补丁,或是将原图像补丁根据尺度金字塔确定几个尺度大小不同的补丁,然后再对图像补丁进行分层、测试。所构建的描述子不仅包含了补丁像素的灰度比较信息,而且包含了灰度排序信息和像素群聚信息,提高了描述子的鲁棒性。结果：通过性能对比实验,发现所提的描述子的性能提高了,而且好于对比的浮点描述子。结论：所以挖掘图像补丁的特征信息能提高二进制描述子的鲁棒性。     

Local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics

Medical image segmentation is of pivotal importance in computer-aided clinical diagnosis. Many factors, including noises, bias field effect, local volume effect, as well as tissue movement may affect the med- ical image, thus causing blurring or uneven characteristics when forming a picture. Such quality defects will inevitably impair the gray-scale difference between adjacent tissues and lead to insufficient segmentation or even leakage during tissue or organ segmentation. In the present investigation, a local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics （LARFS） was proposed. By combining segmentation algorithm principles for traditional region growing （RG） and robust feature statistics （RFS）, the location and neighborhood image information of input seed point can be comprehensively analyzed by LARFS. Results show that, for different segmentation objects, under controlling the input parameter of growing factor within certain range, LARFS segmentation algorithm can adapt well to the regional geometric shape. And be- cause the robust feature statistics is applied in the contour evolution process, LARFS algorithm is not sensitive to noises and not easily influenced by image contrast and object topology. Hence, the leakage and excessive segmentation effects are ameliorated with a smooth edge, and the accuracy can be controlled within the effective error range.