Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment

Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients’ low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients.     

食用油碟式分离机碟片的渗氮激光相变硬化复合处理研究

介绍了食用油碟式分离机碟片的常规表面处理方法,提出了渗氮激光相变硬化复合处理技术,通过硬度实验、耐磨性实验、抗腐蚀性实验及残余应力分布曲线,对实验结果进行了较深入的分析,得出渗氮激光相变硬化复合处理技术可提高4C r13钢碟片抗腐蚀能力和抗疲劳性能的结论。     

2%CrMoNiWV高低压复合转子材料的研究

试验研究了2%CrMoNiWV高低压复合转子材料。试验件在950℃奥氏体化,高压区模拟直径1350mm,模拟喷雾冷速为2.5℃/min,回火温度为660～690℃;低压区模拟直径2500mm,模拟喷水冷速为3℃/min,回火温度为630～660℃。结果表明,综合力学性能达到了目标要求。     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.     

热处理工艺对SCM822H钢的组织及性能的影响

对Cr-Mo系列有代表性钢种SCM822H的临界点、连续冷却曲线进行了测试,探讨了不同热处理状态对其晶粒度、组织和性能的影响,为进一步优化和完善该钢的生产工艺提供了理论依据。     

水电站微机调速器典型故障处理方法

对水电站带空放阀的微机调速器的几个典型故障做了较详细的阐述,分析故障的原因,简要介绍相应的处理方法。     

湿法脱硫GGH结垢原因分析与对策

根据嘉兴发电厂一期2×300MW机组烟气湿法脱硫装置的实际运行情况,分析GGH积灰结垢的原因,提出了相应的对策与控制措施,保障脱硫系统安全、可靠和经济运行。     

烟气预洗涤处理技术在1 000 MW机组无旁路脱硫系统中的应用

通过分析沁北电厂三期工程1 000 MW机组无旁路脱硫系统,论证了湿法脱硫系统采用预洗涤系统的必要性。阐述了预洗涤系统的流程、设计原则、设备选型及实际应用。实践证明,烟气预洗涤系统在控制油污、粉尘和防止高温烟气进入脱硫系统方面效果良好。     

超滤系统的经济运行与维护

对荷兰诺瑞特超滤(UF)系统在深南电(中山)电力有限公司水处理设备中的运行特点和影响因素进行较系统、详细的阐述,总结了经济运行与维护应注意的问题。