γ-氨基丁酸受体同源模建及与黄酮类化合物的分子对接

为研究更有效的γ-氨基丁酸受体激动剂,以海兔烟碱乙酰胆碱结合蛋白(PDB登记号2XYS,0.194 nm)作为模板,运用同源模建的方法构建人γ-氨基丁酸A型受体模型,并利用拉氏图和分子动力学分析验证其模型的合理性.将41个黄酮类化合物与模建的人γ-氨基丁酸A型受体进行对接研究,对接打分与实测活性值相吻合.黄酮类化合物与人γ-氨基丁酸A型受体对接结果显示,黄酮类化合物的母环分别与190位酪氨酸和140位酪氨酸形成共轭,降低体系能量并使体系稳定,验证了模型的合理性.此外,3'位对黄酮类化合物活性的影响至关重要,尤其引入硝基时活性明显提高.38号化合物的对接打分最高,也说明相应的增加取代基个数有利于提高该类化合物活性.     

枝晶间距对镍基单晶合金蠕变性能的影响

为了研究枝晶间距对镍基单晶合金组织与蠕变性能的影响,采用不同抽拉速率制备出两种不同枝晶间距的单晶镍基合金.通过蠕变性能测试及组织形貌观察,研究了枝晶间距对合金成分偏析及蠕变性能的影响.结果表明,随着合金枝晶间距的减小,元素成分偏析程度降低,且在相同热处理条件下,枝晶间距较小的合金具有较好的蠕变性能.合金在稳态蠕变期间的变形机制是位错攀移越过筏状γ′相,而蠕变后期的变形机制是位错在基体中滑移和切入筏状γ′相.蠕变断裂后,在试样不同区域筏状γ′相具有不同的形貌,在远离断口区域,筏状γ′相与应力轴方向垂直,而在近断口区域,筏状γ′相尺寸及扭曲程度均增加.     

大孔Ni_2P/γ-A1_2O_3催化剂的制备及加氢脱硫性能研究

采用酸沉淀法制备大孔γ-Al2O3为载体,并用浸渍法制备Ni2P(25%)/γ-A12O3催化剂。BET、XRD、压汞法的分析结果显示:合成大孔γ-Al2O3载体晶型良好,且具有适宜比表面积和孔结构。催化剂经原位还原处理后,以柴油为原料在连续固定反应装置上,考察了催化剂的制备条件及反应条件对催化剂加氢脱硫活性的影响。结果表明:当载体合成温度为80℃,反应pH为8,反应条件为温度360℃、压力4.0MPa、空速1.0h-1、氢烃体积比500∶1时,催化剂的加氢脱硫活性最好,柴油的脱硫率可达98.2%。     

场地平土和雨水管网的综合优化设计

通过寻求最小土石填挖量的场地标高和坡度设计,在满足土石填挖平衡的基础上,分析了场地平土的优化设计.同时在给定场地坡度的前提下,分析了雨水管网的布置,得出最优的管线布置.其次,将场地平土和雨水管网布置结合起来,在统一考虑场地平土坡度对平土费用和雨水管网布置费用影响的基础上,得出了二者总体费用最小的综合优化模型.最后,通过实例与分步设计方案费用的比较,证实了该综合优化模型的有效性.     

软件外包中分包商选择的优化模型及算法

软件企业常作为发包方将软件项目的某些部分外包给其他企业来转移风险,与多方合作共同承担软件项目的开发,但分包方选择不当同样会给企业带来巨大的风险。为规避分包商选择失误带来的风险,提出了分包商选择的多目标规划模型,该模型以发包方企业成本最小和风险最小为目标对多个软件分包商进行选择。针对模型非线性复杂化整数规划的特点,设计了混合粒子群算法(GA-PSO)对模型进行求解。通过对一个算例的测试,证明了该模型及算法的有效性和可行性。     

The growth of γ-LiAlO2 layer with a highly-preferred orientation on (0001) sapphire

Using vapor transport equilibration (VTE) technique we succeeded in the fabrication of single-phase γ-LiAlO2 layer on (0001) sapphire substrate. X-ray diffraction indicated that the as-fabricated layer was highly textured with [100] orientation at proper VTE treatment temperature range from 1050℃ to 1100℃. The main factors affecting the quality of the γ-LiAlO2 layer were investigated by SEM and transmission spectra. These results reveal the possibility of fabricating γ-LiAlO2 (100)// sapphire (0001) composite substrate for GaN-based epitaxial film by VTE.     

基于能效分布矩阵方程的火电机组热力系统热经济性分析方法

定义了虚拟热力系统的概念,并在常规热平衡法、q—γ—τ矩阵形式和等效热降等概念的基础上,构造了热力系统能效分布矩阵方程。该矩阵方程全面反映了机组主系统和各种辅助系统对机组热经济性的影响状况,每个矩阵物理意义明确、规律性强,可以使热力系统的整体计算和局部分析变得更加清晰、简单、客观,非常适合于计算机程序化。     

基于Canny准则的颗粒图象边缘检测算法

本文详细阐明了Canny准则以及基于Canny准则的算法，并在此基础上结合动态阈值对原有算法加以改进。将其应用于颗粒图象的边缘检测中，取得了良好的效果。     

Chemical Effects of Radiation Emitted from 10B(n, γ)7Li Reaction on Mixture of n-Propylamine and n-Propanol

The long term variation of the mean dose due to natural radiation in Japan received by an individual person was investigated. The mean exposure rate in each prefecture obtained by in-situ measurements was adopted as a basis of the radiation level. Population data were taken from both the resident registration and the census taking into account the essential difference of their meanings. It was revealed that the per capita dose due to outdoor natural radiaiton in Japan has been decreasing in the last approximate 30 yr. It will be due to the population movement from countrysides towards urban areas. That is because countrysides generally consist of stable mountainlands where granitic rocks distribute though urban areas generally consist of alluvial plains where volcanic ash or humus dominates. Although the contribution of low radiation level (below 9.0μR/h) areas to the nation-wide collective dose still remains under 50%, its relative importance has certainly been increasing in the last three decades. It is expected that human population will be the dominating factor which eventually controls the mean dose due to natural radiation in Japan.     

The dependence of fatigue crack growth on hydrogen in warm-rolled 316 austenitic stainless steel

The fatigue crack growth rate of warm-rolled AISI 316 austenitic stainless steel was investigated by controlling rolling strain and temperature in argon and hydrogen gas atmospheres. The fatigue crack growth rates of warm-rolled 316 specimens tested in hydrogen decreased with increasing rolling temperature, especially 400 °C. By controlling the deformation temperature and strain, the influences of microstructure (including dislocation structure, deformation twins and α′ martensite) and its evolution on hydrogen-induced degradation of mechanical properties were separately discussed. Deformation twins deceased and dislocations became more uniform with the increase in rolling temperature, inhibiting the formation of dynamic α′ martensite during the crack propagation. In the cold-rolled 316 specimens, deformation twins accelerated hydrogen-induced crack growth due to the α′ martensitic transformation at the crack tip. In the warm-rolled specimens, the formation of α′ martensite around the crack tip was completely inhibited, which greatly reduced the fatigue crack growth rate in hydrogen atmosphere.