On the polynomial solvability of distributionally robust k-sum optimization

In this paper, we define a distributionally robust k-sum optimization problem as the problem of finding a solution that minimizes the worst-case expected sum of up to the k largest costs of the elements in the solution. The costs are random with a joint probability distribution that is not completely specified but rather assumed to be known to lie in a set of probability distributions. For k=1, this reduces to a distributionally robust bottleneck optimization problem while for k=n, this reduces to distributionally robust minimum sum optimization problem. Our main result is that for a Fréchet class of discrete marginal distributions with finite support, the distributionally robust k-sum combinatorial optimization problem is solvable in polynomial time if the deterministic minimum sum problem is solvable in polynomial time. This extends the result of Punnen and Aneja [On k-sum optimization, Oper. Res. Lett. 18(5)(1996), pp. 233–236] from the deterministic to the robust case. We show that this choice of the set of distributions helps preserve the submodularity of the k-sum objective function which is an useful structural property for optimization problems.     

Efficient Evaluation of Monitoring Top-t Most Influential Places

The continuous top-t most influential place (CTtMIP)query is defined formally and solved efficiently in this paper.A CTtMIP query continuously monitors the t places with the maximum influence from the ...     

Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant

Carbon nanotubes (CNTs) may elicit inflammatory responses following pulmonary exposure. Conversely, enzymatic biodegradation of CNTs by inflammatory cells has also been reported. The aim of this study was to study the degradation of oxidized single-walled CNTs (ox-SWCNTs) by lactoperoxidase (LPO), a secreted peroxidase present in the airways, and whether pulmonary surfactant affects this biodegradation. To this end, ox-SWCNTs were incubated in vitro with recombinant bovine LPO + H₂O₂ + NaSCN in the presence and absence of porcine lung surfactant (Curosurf®) and biodegradation was monitored using UV–Vis–NIR spectroscopy, Raman spectroscopy, and scanning electron microscopy. The interaction of recombinant LPO with bundles of ox-SWCNTs was confirmed by atomic force microscopy. Cell-free biodegradation of ox-SWCNTs was also observed ex vivo in murine bronchoalveolar lavage fluid in the presence of H₂O₂ + NaSCN. Our study provides evidence for biodegradation of ox-SWCNTs with a lung surfactant ‘bio-corona’ and expands the repertoire of mammalian peroxidases capable of biodegradation of ox-SWCNTs. These findings are relevant to inhalation exposure to these materials, as LPO serves as an important component of the airway defense system.     

Nanosponge-based pediatric-controlled release dry suspension of Gabapentin for reconstitution

Abstract

Context: Gabapentin was selected to formulate oral controlled release dry suspension because of short biological half life of 5–7?h and low bioavailability (60%). Gabapentin is a bitter drug so an attempt was made to mask its taste.

Objective: To formulate and evaluate controlled release dry suspension for reconstitution to increase the bioavailability and to control bitter taste of drug.

Materials and methods: Cyclodextrin based nanosponges were synthesized by previously reported melt method. The nanosponge–drug complexes were characterized by FTIR, DSC and PXRD as well as evaluated for taste and saturation solubility. The complexes were coated on Espheres by a suspension layering technique followed by coating with ethyl cellulose and Eudragit RS-100. A dry powder suspension for reconstitution of the microspheres was formulated and evaluated for taste, redispersibility, in vitro dissolution, sedimentation volume, leaching and pharmacokinetics.

Results and discussion: The complexes showed partial entrapment of drug nanocavities. Significant decrease in solubility (25%) was observed in the complexes than pure drug in different media. The microspheres of nanosponge complexes showed desired controlled release profile for 12?h. Insignificant drug leaching was observed in reconstituted suspension during storage for 7 days at 45?°C/75% RH. Nanosponges effectively masked the taste of Gabapentin and the coating polymers provided controlled release of the drug and enhanced taste masking. The results of in vivo studies showed increase in bioavailability of controlled release suspension by 24.09% as compared to pure drug.

Conclusion: The dry powder suspension loaded with microspheres of nanosponges complexes can be proposed as a suitable controlled release drug delivery for Gabapentin.     

PEIOO-RC管道专用料的发展及国内应用情况

本文简要介绍了聚乙烯（PE）压力管道材料的发展、耐开裂聚乙烯（PEl00一RC）材料的定义,PE压力管道混配料质量性能及要求,特别是PEl00一RC的关键技术要求、应用经济性能比较及绿色环境效益,还介绍了PEl00一RC管道在国内的应用情况。     

Development of mefenamic acid–loaded polymeric microparticles using solvent evaporation and spray-drying technique

Ethyl cellulose (EC) and Eudragit RL-100 (ERL-100) were used for the preparation of sustained released microparticles of mefenamic acid (MFN) by using oil-in-oil (o/o) solvent evaporation as well as spray drying. A Plackett-Burman design was employed using Design-Expert software. The resultant microparticles were characterized for their size, surface morphology, encapsulation efficiency, and drug release. Imaging of microparticles was performed by field emission scanning electron microscopy. The drug and polymer interaction was investigated by Fourier transform infrared (FTIR) spectroscopy and X-ray powder diffractometry (XRPD). The microparticles showed encapsulation efficiency in the range of 29.44 to 89.20% by solvent evaporation and 83.73 to 96.69% by spray drying. The surface of the microparticles was smooth, round, and regular, without any erosion and cracking. The size of the microparticles was found to be in the range of 6.55 to 41.1 µm. FTIR analysis confirmed no interaction of MFN with the polymers. XRPD showed the dispersion of the drug within the microparticle formulation. These results helped in finding the optimum formulation variables for encapsulation efficiency (EE) of microparticles.     

基于AMESim的100%低地板轻轨车制动系统仿真研究

100%低地板轻轨车是目前城市轨道交通系统中发展十分迅速的交通形式。由于它采用低地板结构,导致车下空间狭小,需采用体积较小的液压制动系统。针对应用最普遍的2M1T模块的100%低地板轻轨车制动系统进行研究,在提出制动系统方案的基础上运用AMESim软件完成制动系统建模,选择超员载荷工况下的最大常用制动和紧急制动两种制动工况进行仿真分析,仿真结果验证了该方案的正确性,可对100%低地板轻轨车制动系统的研究与开发提供参考。     

Effect of Ionic Liquids on Surface and Aggregation Properties of Non-ionic Surfactant Triton™ X-100 in Aqueous Media

The effect of the hydrophilic ionic liquids (ILs) 1-butyl-2,3-dimethylimidazolium bromide [bdmim][Br] and 1-hexyl-2,3-dimethylimidazolium bromide [hdmim][Br] on the aggregation and surface active behaviour of the non-ionic surfactant Triton? X-100 (TX-100) was studied in aqueous media. Several aggregation properties of TX-100 + IL/water systems, such as critical micelle concentration (CMC), surface active parameters, aggregation number (N _agg) and aggregate size, were determined by surface tension, fluorescence and dynamic light scattering (DLS) techniques. It was found that the average micellar size and aggregation number decrease, whereas the CMC increases with increasing concentration of ILs. Interestingly, the CMC value of TX-100 is reduced slightly below 0.5 wt% of both the ILs in the medium. At higher wt% of IL in the system the CMC increases. It was demonstrated that ILs [bdmim][Br] and [hdmim][Br] can be judiciously used at different wt% for modifying the physico-chemical properties of TX-100.