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41.
Gleevec是抑制致癌的融合蛋白BCR-ABL的一种分子靶向治疗药物,BCR-ABL是一种与慢性髓细胞性白血病(CML)有关的酪氨酸激酶抑制剂。用Gleevec选择性地抑制BCR-ABL活性在治疗CML中显示出很好的效果,特别是在CML慢性期,因此,监测疗效非常重要。现就Gleevec的研究进展及如何监测其在CML中的疗效作一简单综述。 相似文献
42.
Joel P. Martin J. Edward Swan II Robert J. Moorhead II Zhanping Liu Shangshu Cai 《Computer Graphics Forum》2008,27(3):991-998
We present the results from a user study looking at the ability of observers to mentally integrate wind direction and magnitude over a vector field. The data set chosen for the study is an MM5 (PSU/NCAR Mesoscale Model) simulation of Hurricane Lili over the Gulf of Mexico as it approaches the southeastern United States. Nine observers participated in the study. This study investigates the effect of layering on the observer's ability to determine the magnitude and direction of a vector field. We found a tendency for observers to underestimate the magnitude of the vectors and a counter‐clockwise bias when determining the average direction of a vector field. We completed an additional study with two observers to try to uncover the source of the counter‐clockwise bias. These results have direct implications to atmospheric scientists, but may also be able to be applied to other fields that use 2D vector fields. 相似文献
43.
波分复用系统将不同波长的光复用在一起进行传输,以满足对传输容量和传输距离的各种需求。介绍了一种开销监视与提取的设计方法,使用VSC8150提取承载在波分复用系统相应波长上SDH信号的开销。分析了VSC8150的工作原理,管脚和外部接口,以及与FPGA、单片机共同完成B1重新计算,开销提取,B1,J0提取。此外,还提出将帧丢失,帧失步等错误状态传送给单片机和网管的方法。本设计增强了波分复用系统网管管理参数,功能和灵活性,这会在系统维护时带来较大的方便。该设计已经成熟应用在实际的波分复用系统中。 相似文献
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No authorship indicated 《Canadian Metallurgical Quarterly》2003,58(8):554
Presents the 2003 American Psychological Foundation's Gold Medal Award for Life Achievement in the Science of Psychology, which was presented to Robert Rosenthal. A biography of Rosenthal is provided, along with a selected bibliography and the text of the award citation: "For outstanding scientific contributions that have had a profound influence on research methods, empirical investigations, theory, and applications. Robert Rosenthal's seminal research on interpersonal expectancy inspired hundreds of studies with applications within and beyond psychology. His amplification of experimenter- and subject-related artifacts and his insights about ethical issues have improved the way that research is conducted. His statistical contributions are classic and wide ranging, including his body of work on meta-analysis and contrast analysis and his formulation of valuable procedures, such as the binomial effect-size display and counternull statistics. An exceptional scientist, teacher, mentor, and author, Rosenthal, with his generous and brilliant touch, has shaped the lives and work of countless others." (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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该文介绍了Mall的产生条件和国内发展概况,并结合实例分析,着重论述建筑设计方面的有关问题。 相似文献
49.
B. P. PEHRSON J. D. LANDES 《Fatigue & Fracture of Engineering Materials & Structures》2007,30(2):73-86
The purpose of this study is to examine the current standard fracture toughness test procedure to determine if there could be an easier method to get a JIc value from the test record. The current method for determining JIc involves a detailed computational and construction procedure. The objective in this study is to simplify the analysis for the determination of JIc. The results of this study show that the load and displacement record for a fracture toughness test can be used to directly estimate a JQ value, a provisional value for fracture toughness, JIc. The J value taken at the maximum load point can be used along with an adjustment factor to estimate a JQ value. This JQ estimate is close to the one obtained from the construction procedure of ASTM Standard E 1820. When a unit‐sized specimen is tested, that is, a specimen with a width of 50 mm and a thickness of 25 mm the maximum load point provides a direct estimate of JQ. Other sizes require a size adjustment factor, which is simply a square root relationship between the width of the test specimen and a unit width. The proposed new method of estimating JQ is simple in concept and requires a minimum number of calculations. It appears to produce values of JQ which are comparable to those obtained from the ASTM E1820 construction procedure and may produce less scatter. 相似文献
50.
No authorship indicated 《Canadian Metallurgical Quarterly》2007,62(5):388
Announces the 2007 recipient of the Gold Medal Award for Life Achievement in the Practice of Psychology: Patricia M. Bricklin. A brief biography, highlighting areas of special focus in Bricklin's work, is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献