高温炉管断裂的两种机制

通过对过热炉管受热冲击影响的事件考察，指出了在高温炉管的断裂中存在着超温引起过早的蠕变断裂，通常有明显的变形和热冲击导致快速的脆性断裂两种不同的机制。在失效成因的分析中，讨论了Manson—Haferd参量外推技术、热应力沿壁厚的分布和热冲击产生应力峰值问题，给出了热冲击的安全曲线。     

Characterization of residual stresses from cold expansion using spatial statistics

Residual stress fields from cold expansion have been widely used to extend the fatigue life of aircraft structures. However, the spatial statistical character of these residual stress fields has not been established and has not been incorporated in current analysis methods. The objective of this study was to establish a spatial statistical method to quantify the residual stress field around a cold expanded hole. A framework called the Spatial Analysis of Residual Stress (SpARS) was developed utilizing spatial correlation, response surface modelling techniques and statistical resampling methods to characterize the residual stress field. Our results showed that tolerance bounds on residual stress can be quantified using this method. We also demonstrated the SpARS method using recently published round robin case studies. The newly developed model will be useful for aircraft structural fatigue crack growth analyses to incorporate residual stress fields for extending inspection intervals for fatigue and fracture critical structures.     

水中爆炸对围岩增耦的实验研究

为研究水中爆炸对围岩的增耦,在一个直径1.6 m的水泥砂浆半球体装置上,将其中心预留的直径0.3 m的腔室内注水和置入水泥砂浆芯体,对比性地进行了一系列的1.00 gTNT(2,4,6-三硝基甲苯)当量的填实和空腔爆炸实验.水泥砂浆球表运动测量数据表明,与水泥砂浆中的空腔解耦相比,水中空腔爆炸的解耦效果较差,尤其水腔中爆炸可大大增强爆炸能量的耦合.可以推断,水下爆炸会明显增强围岩中的爆炸应力波强度,近水域中的空中爆炸也可能会增强围岩中的爆炸能耦合,因而相对于围岩和堤坝中同距离、同药量的爆炸来讲,所引起的破坏危险更大.     

Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes

Curcumin has been suggested as a promising treatment for metabolic diseases, but the high doses required limit its therapeutic use. In this study, a new curcuminoid is synthesised to increase curcumin anti-inflammatory and antioxidant potential and to achieve hypoglycaemic and protective vascular effects in type 2 diabetic rats in a lower dose. In vitro, the anti-inflammatory effect was determined through the Griess reaction, and the antioxidant activity through ABTS and TBARS assays. In vivo, Goto-Kakizaki rats were treated for 2 weeks with the equimolar dose of curcumin (40 mg/kg/day) or curcuminoid (52.4 mg/kg/day). Fasting glycaemia, insulin tolerance, plasma insulin, insulin signalling, serum FFA, endothelial function and several markers of oxidative stress were evaluated. Both compounds presented a significant anti-inflammatory effect. Moreover, the curcuminoid had a marked hypoglycaemic effect, accompanied by higher GLUT4 levels in adipose tissue. Both compounds increased NO-dependent vasorelaxation, but only the curcuminoid exacerbated the response to ascorbic acid, consistent with a higher decrease in vascular oxidative and nitrosative stress. SOD1 and GLO1 levels were increased in EAT and heart, respectively. Altogether, these data suggest that the curcuminoid developed here has more pronounced effects than curcumin in low doses, improving the oxidative stress, endothelial function and glycaemic profile in type 2 diabetes.     

Modulation of Steroid and Triterpenoid Metabolism in Calendula officinalis Plants and Hairy Root Cultures Exposed to Cadmium Stress

The present study investigated the changes in the content of steroids and triterpenoids in C. officinalis hairy root cultures and plants exposed to cadmium stress. The observed effects included the content and composition of analyzed groups of compounds, particularly the proportions among individual sterols (e.g., stigmasterol-to-sitosterol ratio), their ester and glycoside conjugates. The total sterol content increased in roots (by 30%) and hairy root culture (by 44%), whereas it decreased in shoots (by 15%); moreover, these effects were inversely correlated with Cd-induced growth suppression. Metabolic alterations of sterols and their forms seemed to play a greater role in the response to Cd stress in roots than in shoots. The symptoms of the competition between general metabolites (sterols) and specialized metabolites (triterpenoids) were also observed, i.e., the increase of the sterol biosynthesis parallel to the decrease of the triterpenoid content in C. officinalis plant roots and hairy root culture, and the inverse phenomenon in shoots. The similarity of the metabolic modifications observed in the present study on C. officinalis plant roots and hairy roots confirmed the possibility of application of plant in vitro cultures in initial studies for physiological research on plant response to environmental stresses.     

Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosclerosis and, like the latter, partly of inflammatory origin. Patients with high-grade AVS have a highly disturbed blood flow associated with high levels of shear stress. The immediate reopening of the valve during TAVR leads to a sudden restoration of a normal blood flow hemodynamic. Despite its good prognosis for patients, TAVR remains associated with bleeding or thrombotic postprocedural complications, involving mechanisms that are still poorly understood. Many studies report the close link between blood coagulation and inflammation, termed thromboinflammation, including monocytes as a major actor. The TAVR procedure represents a unique opportunity to study the influence of shear stress on human monocytes, key mediators of inflammation and hemostasis processes. The purpose of this study was to conduct a review of the literature to provide a comprehensive overview of the impact of TAVR on monocyte phenotype and subset repartition and the association of these parameters with the clinical outcomes of patients with severe AVS who underwent TAVR.     

有岩爆倾向深井矿山采矿巷道的失稳模式分析及其控制技术

冬瓜山铜矿深井具有高应力(30～38 MPa)、存在岩爆倾向的特点。根据原岩应力测量、岩石物理力学试验、岩体结构调查、数值模拟计算以及工程实际, 详细分析了处于各类岩体中的采矿巷道的失稳模式, 针对采矿巷道的岩体特性、工程部位及其作用以及预测破坏模式, 提出了不同的支护方式及参数, 取得了较好的效果。     

不同地应力下的地下硐室动态特征分析

采用FLAC3D对地震动荷载作用下不同地应力状态的地下岩体硐室的动态特性进行了初步分析。分析结果表明,地震荷载作用下,硐室位移随地应力侧压系数的增加明显减小,地应力侧压系数λ<1时的硐室位移量值随侧压系数的变化幅度明显大于地应力侧压系数λ>1时的情况;当侧压系数λ<1,随剪切波入射角的变化,硐室测量点位移响应先增加后减小;而当侧压系数λ>1,随剪切波入射角的增加,硐室测点位移先减小后增加,同时随地应力侧压系数的增加有减小的趋势。     

基于露天矿高陡边坡岩体的爆炸应力波响应仿真研究

通过爆炸应力波在高陡边坡体远场传播的三自由度动力学模型,利用Matlab仿真了其动态响应过程。单点爆源的爆炸应力波激励的仿真结果表明,边坡岩体介质位移响应下部的最大,中部的次之,上部的最小,之间呈幂律关系衰减,同时具有明显的滞后效应;频率响应与位移响应相同,随着步长增加,高频成份迅速衰减。多点爆源的爆炸应力激励仿真结果表明,边坡岩体介质位移响应上部的最大,中间的次之,下部的最小,爆炸应力波在边坡顶部呈动力放大效应;频率响应则相反,下部最大,中部的次之,上部最小。仿真结果与现场测试结果相符。