Disposable 3D GNAs/AuNPs DNA‐Circuit Strip for miRNAs Dynamic Quantification

Real‐time quantitative monitoring of miRNAs plays an essential role in diagnosis and therapeutics. Herein, a DSN‐coupled graphene nanoarray/gold nanoparticles (GNAs/AuNPs) carbon paper (CP) electrode for the dynamic, sensitive, and real‐time analysis of miRNAs is reported. GNAs are vertically grown on the conductive CP by radio frequency plasma enhanced chemical vapor deposition, and AuNPs are electrodeposited on CP/GNAs to build a 3D ultrasensitive sensing interface with large specific surface area, good conductivity and biocompatibility. The dynamic quantitative monitoring of microRNA‐21 (miR‐21) is realized by cyclic voltammetry with a series of different concentrations within 16 min, and this 3D GNAs/AuNPs DNA‐circuit strip shows good performance for the simultaneous detection of miR‐21 and miR‐155, and the detection limits are as low as 21.4 and 30.3 am, respectively. Moreover, comparable detection results are achieved for clinical samples between the proposed sensor and qRT‐PCR, suggesting the reliability of the constructed sensor. This ultrasensitive sensing and disposable DNA‐circuit strip with 3D structure can efficiently shorten the diffusion distance between reactive biomolecules and the sensing interface, enhance the hybridization of probes and improve the sensitivity of the biosensor, holding great promise for the rapid, quantitative and dynamic monitoring of multiple low concentrations of biomolecules in point‐of‐care clinical analysis.     

基于NSGAⅡ的高精铜板带配料优化问题

为实现高精铜板带配料过程的优化,建立了考虑降低成本、减少烧损、循环利用旧料且满足多种旧料可代用性等配料原则的配料优化模型,并利用拉格朗日松弛法对模型进行了变换.针对所建模型,设计了基于第2代非支配排序遗传算法（NSGAⅡ）的求解方法,重点研究了染色体表示、比较算子和基于模糊集合理论的Pareto选优方法.研究结果表明,与现有配料算法相比,此种求解方法可获得更优的结果且一次运行便可提供多种可行的配料方案.     

TC17钛合金整体叶盘腐蚀表面“亮条”的成因及其对性能的影响

存对半成品TC17钛合金整体叶盘进行表面腐蚀俭查时,发现有的表面存在“亮条”的则象。通过显微组织观察、成分分析、硬度和力学性能测试等手段对“亮条”产生的原因及其对产品力学性能的影响进行了研究,由于TC17钛合金铸锭头部容易产生Cr偏析,从而形成Cr元素富集区,这些区域的相变点温度比基体低25～30℃,存热加工过程中形成了β斑点。这些β斑点即是“亮条”产生的原因。由于整体叶盘表面的β斑点较小,对室温拉伸性能和低剧疲劳性能影响小大,仍满足使用要求。     

New Realization Method for Airborne SAR Motion Compensation

After analyzing the characteristics of airborne SAR motion deviation in detail, a new realization method for airborne SAR motion compensation based on two-dimensional division processing is described. By combining the division of local tracks in azimuth direction and the division of sub-mapping strips in range direction, the motion deviation will be compensated accurately. Furthermore, both theoretic analysis and simulation result show that by using this method the problems of motion compensation under complex condition with large motion deviation and large mapping strip width can be resolved well.     

A Fracture Mechanics Approach to Failure in Fibrous Composites

This paper presents a review of the fracture processes which occur in brittle thermosetting resins containing long strong fibers of carbon, boron and glass. Important material variables affecting the fracture behavior of the fibrous composite include fiber strength and strength of the fiber-matrix interface. Other parameters which must be considered include component geometry, environment, loading mode and nondestructive inspection capability. The effects of microstructural features including fiber volume fraction, together with a consideration of the fiber-resin interface are discussed in relation to the fracture stress and toughness of the composite material. The influence of the fiber-resin interface and environment on slow crack growth in carbon fiber-reinforced epoxy resin is also reviewed.     

螺旋纽带自动清洗式高效蒸发器技术可行性研究

螺旋纽带自动清洗式高效蒸发器的技术原理 ,是利用蒸发溶液的循环流动能带动加热管内的螺旋纽带旋转清洗结晶垢。根据结晶动力学原理 ,采用碳钢管内Na2 SO4 、KCLO3的冷却过饱和溶液的结晶盐垢进行流体动力学模拟清洗试验。结果表明 ,螺旋纽带的旋转清洗能力能够满足蒸发器结晶垢的自动清洗要求 ,使蒸发生产长期连续 ,能力提高 ,能耗降低 ,可以在制糖、制盐、烧碱、化工、食品、制药等工业生产部门广泛应用 ,获得相当高的综合经济效益     

大面积无筋混凝土整体地面的裂缝控制

结合哈尔滨国际机场跑道,停机坪,飞机维修库地面施工,正确地分析了大面积无筋混凝土整体面施工阶段的裂缝出现的原因是变形变化引起的,即结构由温度,收缩与膨胀,不均匀积降等因素引起的。通过工程实践和理论分析提出了行之有效的控制裂缝限度的施工技术措施：采用分条跳仓浇筑法,控制混凝土配合比的水泥和水的用量以及骨料级配,加强混凝土的振捣和养护,设置永久性缩缝。     

智能教学系统中自动推理模块的设计与实现

以本实验室研制的约束逻辑程序设计系统BPU-CLP为基础,研制了一个适用于中学数学,面向学生的智能教学系统BPU-ITS-Math. 介绍了BPU-ITS-Math的自动推理模块的设计方法和实现技术,BPU-ITS-Math采用经典的Strips算子表达规则,用BPU-CLP语言的程序实现学科知识库、题库和通用推理机. 以中学教学求函数值域问题为例,详细介绍了规则的设计方法和表达方式,并且给出了通用推理机的向后推理算法. 当前BPU-ITS-Math已成功地解决了200余道求函数值域的习题.     

粘贴竹片加固木梁的研究

木结构使用功能变更或使用荷载增加均可能导致木梁受弯承载力不足,需采用措施进行加固。共进行了6根木梁采用竹片加固的对比试验研究,其中3根为对比试件,3根为粘贴竹片加固木梁试件。研究结果表明:粘贴竹片加固木梁受弯承载力可提高48.0%～83.1%,平均提高69.5%;同时破坏位移亦有所增加。加固木梁跨中截面仍基本符合平截面假定;在相同荷载作用下,加固木梁受拉边缘拉应变和受压边缘压应变明显小于对比试件;不同位置竹片随荷载增加时的应变变化基本一致,且应变值相近。粘贴竹片加固木梁是一种低碳高效的加固技术。     

格构木梁加固方法的研究

进行了10根木梁的对比试验研究,其中3根为对比普通木梁,3根为未加固格构木梁,4根为加固格构木梁。研究结果表明:未加固格构木梁的受弯承载力和初始弯曲刚度较普通木梁均略有降低;底面粘贴1层碳纤维(CFRP)布加固格构木梁的受弯承载力较未加固格构木梁显著提高54%,初始弯曲刚度提高34%,极限位移显著提高63%。空隙处采用结构胶或灌浆料填充的格构木梁的受弯承载力平均提高30%,初始弯曲刚度显著提高195%,极限位移则显著降低54%。结构胶填充并在梁底面粘贴1层CFRP布的加固格构木梁受弯承载力显著提高92%,初始弯曲刚度显著提高251%,极限位移则降低48%。未加固格构木梁和粘贴1层CFRP布加固格构木梁的受拉肢和受压肢跨中应变变化分别保持平截面假定;其受压肢和受拉肢均为下侧受拉上侧受压,中间木垫块基本不受力。空隙采用结构胶填充的加固格构木梁跨中全截面应变变化基本保持平截面假定;其受压肢受压,受拉肢受拉,中间木垫块亦参与全截面受力。研究表明:在格构木梁空隙处填充灌浆料或结构胶可显著提高其初始弯曲刚度,但对提高承载力不显著;在格构木梁底面粘贴CFRP布可显著提高其承载力,但对提高初始弯曲刚度不明显。格构木梁有限元数值模拟结果可满足工程应用的精度要求。