ABSTRACT In recent debates on the issues of privacy and the Internet, Deep Packet Inspection (DPI) has been grossly oversimplified as a technology that is primarily harmful to consumers. Much of the commentary has been based on a poor understanding of what DPI is and how DPI works. All too often the debate over DPI is focused on unrelated issues such as free speech and censorship, which are largely political and not technological issues. DPI usage has been described as a violation of consumer privacy when the reality is far more complex and nuanced. What has been missing is a broader discussion on the full nature and application of DPI technology; DPI enables a wide range of applications, most of which are not only positive but also essential to the survival of the Internet. This paper will explain how DPI technology works and explore practical applications of its use. DPI will be an important tool to control economies of scale with the explosive growth of the Internet. While there will always be privacy concerns over the intrusive nature of DPI technology, this worry will be overshadowed by the security and control it allows. 相似文献
Context: Dry powder inhalers (DPIs) consisting of a powder mixture containing coarse carrier particles (generally lactose) and micronized drug particles are used for lung drug delivery. The effective drug delivery to the lungs depends on size and shape of carrier particles. Thus, various methods have been proposed for engineering lactose particles to enhance drug delivery to lungs.
Objective: The objective of current work was to assess suitability of electrospray technology toward crystal engineering of lactose. Further, utility of the prepared lactose particles as a carrier in DPI was evaluated.
Materials and methods: Saturated lactose solutions were electrosprayed to obtain electrosprayed lactose (EL) particles. The polymorphic form of EL was determined using Fourier transform infrared spectroscopy, powder X-ray diffractometry, and differential scanning calorimetry. In addition, morphological, surface textural, and flow properties of EL were determined using scanning electron microscopy and Carr’s index, respectively. The aerosolization properties of EL were determined using twin-stage impinger and compared with commercial lactose particles [Respitose® (SV003, Goch, Germany)] used in DPI formulations.
Results and discussion: EL was found to contain both isomers (α and β) of lactose having flow properties comparable to Respitose® (SV003). In addition, the aerosolization properties of EL were found to be significantly improved when compared to Respitose® (SV003) which could be attributed to morphological (high elongation ratio) and surface characteristic (smooth surface) alterations induced by electrospray technology.
Conclusion: Electrospray technology can serve as an alternative technique for continuous manufacturing of engineered lactose particles which can be used as a carrier in DPI formulations. 相似文献