Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma

Primary vitreoretinal lymphoma (PVRL) or primary intraocular lymphoma, a subtype of primary central nervous system lymphoma, often masquerades as uveitis. The diagnosis of PVRL requires identification of lymphoma cells inside the eye, which is often challenging due to the frequent necrosis and admixing of PVRL cells with reactive lymphocytes. Therefore, detection of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements provide molecular diagnosis of B- and T-cell lymphoma, respectively. We retrospectively evaluated 208 cases with a clinical diagnosis of masquerade syndrome from 1998 to 2010. In 200 cases with molecular analyses using microdissection and polymerase chain reaction, we found that 110 cases had IgH gene rearrangement, 5 cases had TCR gene rearrangement, and 85 cases were negative for these two gene arrangements. The molecular data corroborated the cytopathological diagnoses of PVRL and uveitis in the majority of cases. Cytokine above the detected levels in the specimens were also measured in 80 of the 208 cases. A ratio of vitreous IL-10 to IL-6 greater than 1, suggesting PVRL, was found in 56/80 cases; 53/56 had the correct diagnosis. A ratio less than 1, suggesting uveitis, was found in 24/80 cases; 17/24 correctly confirmed the diagnosis. Moreover, the molecular data corresponded well with the clinical course of the diseases. The sensitivity and specificity of these molecular biomarkers for the diagnosis of PVRL are higher than 95%.     

关于锅炉胀口泄漏修复的探讨

锅炉胀口在大面积管群泄漏时宜采用胀接修复法，而不宜采用焊接修复法的原因．传统的胀接工艺采用锅炉胀口交错排列或顺排列反阶式方法，它对新制造的锅炉是可行的，但对于在役锅炉大面积管群泄漏的修复往往效果不好．在此推出我们所设计的插花式胀管次序，多次实践已证明了其明显的优势．同时，还介绍了个别管孔经补胀后仍泄漏的修复法．     

蓄能供热型太阳能集热器结构优化

提出一种蓄能供热型太阳能集热器,将太阳能真空集热管、重力热管蒸发段、热泵蒸发器和相变材料集于一体,可有效克服太阳辐射波动性影响,结构紧凑,集热效率高. 利用FLUENT软件模拟研究蓄能供热型太阳能集热器内相变材料的蓄放热特性. 对比分析集热器内不同结构:重力热管蒸发段和蒸发器管路采用并排布置或三角布置时相变材料的温度场和速度场,结果表明,并排布置方式优于三角布置方式,相变材料完全熔化时间可缩短22.6%,完全熔化时相变材料储存的热量更多. 研究集热器倾斜角度对相变材料蓄热/释热过程的影响,结果表明,蓄热过程倾斜放置比竖直放置时相变材料的完全熔化时间缩短了约28%,而释热过程完全熔化时间不受倾斜角度的影响. 最后研究了相变材料的相变温度和相变潜热对相变过程的影响,结果表明,在能够满足相变材料蓄热所需的相变温度范围内,应选取相变温度较低、相变潜热较大的相变材料.     

Pore pressure development in hybrid fibre-reinforced high strength concrete at elevated temperatures

The present experimental work investigates the build-up of pore pressure at different depths of High Strength Concrete (HSC) and Hybrid-Fibre-Reinforced High Strength Concrete (HFRHSC) when exposed to different heating rates. First, the effect of the measurement technique on maximum pore pressures measured was evaluated. The pressure measurement technique which utilised a sintered metal and silicon oil was found to be the most effective technique for pore pressure measurement. Pore pressure measurements carried out showed that addition of polypropylene fibres is very effective in mitigation of spalling and build-up of pore pressure inside heated HSC. Addition of steel fibres plays some role in pore pressure reduction at relatively higher pressures in deeper regions of concrete during fast heating. Pore pressure development is highly influenced by the rate of heating with fast heating leading to higher pore pressures in the deeper regions of concrete compared to slow heating.     

蒸汽管道设计要点分析

蒸汽管道是化工装置中重要的公用工程管道。从工艺系统和管道布置角度出发,阐述了蒸汽管道管径的合理原则、管道布置和应力的结合、蒸汽疏水系统的设置、蒸汽冷凝液的回收以及蒸汽管道布置避免水锤现象的设计要点。     

涉外项目离心式消防水泵的设计选用要点

与石油化工流程泵的选用不同,离心式消防水泵的选用自成体系,涉外项目消防水泵的选择通常要求遵守NFPA 20标准.简要介绍了消防水泵及其驱动机、控制系统的选型要求,介绍了相关消防产品的认证,以及工程设计中所遇到的相关问题.     

构建现代城市的多元化特色空间——湖北省京山县人民广场规划设计投标方案介绍

在详细分析京山县人民广场设计背景以及对现状用地和周边环境进行认真调查的基础上 ,介绍了该投标方案的设计内容 ,其中包括规划定位和设计目标、功能布局和空间设计、景观组织和交通组织、设计意境等 .本设计不追求气魄 ,旨在寻求功能的多元化和绿色的生态化     

新型包装材料CFP的研制

本文论述了新型包装材料CFP的研制原理、生产工艺、技术性能及特点,介绍了CFP与其它复合材料的性能比较及其应用范围。     

分布器结构对气固鼓泡流化床内气相分布影响的数值模拟

根据双流体模型,利用计算流体力学软件Fluent 6.3,在布风板开孔率Φ=3.86%时,对6种布孔方式不同的流化床中气相的分布特性进行了数值模拟,得到了各布孔条件下气相分布规律。结果显示,均匀布孔流化床内产生大量的气泡,气泡分布不均且存在大片流化率很低的区域。在各不均匀布孔流化床中,大小孔间隔排布布风板流化床(E型布风板流化床)内产生的气泡相对较小且分散性较好,气相速度矢量分布较分散均一,流化效果最好。与均匀布孔流化床相比,E型布风板的流化床轴向气相压力脉动更小,径向等压线分布更平缓,表现出轴向和径向气相分布更均匀,对鼓泡流化床的优化设计最有参考价值。     

排列方式对Y形单元厚屏频率选择表面传输特性的影响

厚屏频率选择表面（TFSS）是在薄屏FSS基础上,通过增加金属屏厚度,构成一种波导单元传输模式的新型FSS,使其具有更好的中心频点稳定性和工作带宽特性。本文通过设计一种Y型单元的TFSS结构,并利用矩量法,研究了单元排列方式对其传输特性的影响。结果表明：TFSS的工作带宽较薄屏FSS的工作带宽大,且随着单元排布紧密程度上升;随着单元排布紧密程度上升,透过率和带宽都呈上升趋势;电磁波正入射较斜入射的工作带宽大,透过率随着单元排布紧密程度上升,而趋于稳定;随着金属屏厚度的增加,透过率和工作带宽都呈减小趋势。