Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion

In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funny current (I(f)), Ivabradine may also play a role against cardiac necrosis by reducing EMMPRIN/CyPA-mediated cardiac inflammation. In a porcine model of cardiac ischemia/reperfusion (IR), we found that administration of 0.3 mg/kg Ivabradine significantly improved cardiac function and reduced cardiac necrosis by day 7 after IR, detecting a significant increase in cardiac CyPA in the necrotic compared to the risk areas, which was inversely correlated with the levels of circulating CyPA detected in plasma samples from the same subjects. In testing whether Ivabradine may regulate the levels of CyPA, no changes in tissue CyPA were found in healthy pigs treated with 0.3 mg/kg Ivabradine, but interestingly, when analyzing the complex EMMPRIN/CyPA, rather high glycosylated EMMPRIN, which is required for EMMPRIN-mediated matrix metalloproteinase (MMP) activation and increased CyPA bonding to low-glycosylated forms of EMMPRIN were detected by day 7 after IR in pigs treated with Ivabradine. To study the mechanism by which Ivabradine may prevent secretion of CyPA, we first found that Ivabradine was time-dependent in inhibiting co-localization of CyPA with the granule exocytosis marker vesicle-associated membrane protein 1 (VAMP1). However, Ivabradine had no effect on mRNA expression nor in the proteasome and lysosome degradation of CyPA. In conclusion, our results point toward CyPA, its ligand EMMPRIN, and the complex CyPA/EMMPRIN as important targets of Ivabradine in cardiac protection against IR.     

V2O5/g⁃C3N4催化剂的制备及其模拟油中硫化物的脱除

以三聚氰胺、偏钒酸铵、硼酸为前驱体,通过煅烧法制备V₂O₅/g⁃C₃N₄催化剂。采用XRD、FT⁃IR、XPS、SEM和BET等技术对催化剂的结构与形貌进行表征。以V₂O₅/g⁃C₃N₄为催化剂,乙腈为萃取剂,H₂O₂为氧化剂对模拟油中二苯并噻吩（DBT）的脱除进行考察。探究了反应温度、催化剂质量、萃取剂体积、n(H₂O₂)/n(S)以及不同硫化物等因素对脱硫效果的影响。在模拟油体积为5.0 mL、萃取剂乙腈体积为3.0 mL、n(H₂O₂)/n(S)=8、催化剂质量为0.02 g、反应温度为30 ℃和反应时间为60 min的最佳条件下,DBT的脱除率达到91.9%,经过5次催化剂再生后脱硫率仍可以达到85.7%。     

欠驱动异构式下肢康复机器人动力学分析及参数优化

针对现有外骨骼机器人人机自由度不匹配和关节对中性差的问题,提出欠驱动下肢康复机器人. 欠驱动机器人只有4个直线驱动,驱动的直线运动通过推杆和人机连接机构转化为人下肢在矢状面内的屈伸运动,带动人体进行步态康复训练. 建立机器人系统的人机耦合模型,进行模型的动力学分析,对人机耦合模型中影响动力学结果的参数进行分析,建立驱动力与肢体推动力之间的关系模型,并以推力系数最大为目标进行参数分析与优化,得到最佳的结构参数. 根据优化后的结构参数搭建康复机器人实验系统,对髋、膝关节驱动力与角度进行对比. 实验结果表明最大髋关节角度误差为2.9°,最大膝关节角度误差为6.4°,最大误差均约为9%,验证了动力学模型和参数优化结果的正确性.     

单关节机器人伺服系统的建模与仿真

为了深入研究机器人驱动系统,需要进行单关节机器人伺服系统的建模与仿真。首先对单关节机器人的规划轨迹、机械结构、电气结构和控制器分别建立数学模型;然后根据数学模型在MATLAB/Simulink平台上搭建伺服系统的仿真模型;最后对仿真结果做了分析,为机器人系统的优化设计与调试提供了有效模型和依据。     

短开路耦合谐振器加载的宽带带通滤波电路

提出了一种基于短开路耦合器加载的宽带带通滤波电路. 该滤波电路通过在输入和输出端口之间,并连加载短路耦合微带谐振器和开路耦合微带谐振器实现5个传输极点和3个传输零点的带通选择特性. 对所提出的短开路耦合谐振器进行了奇偶模理论分析,揭示了其传输零极点形成的物理机理. 最后,对所提出的滤波电路进行了加工测试. 测试结果表明,所提出的宽带滤波电路能够在2.0～4.2 GHz频率范围内实现 3 dB 带通传输,工作相对带宽为73%,仿真和实测结果吻合较好.     

某660 MW火电机组调试期间DCS逻辑优化与修改

DCS系统调试的质量与机组顺利投产和安全运行紧密相关。新建火电机组DCS系统逻辑组态由于多方面原因往往存在着单点保护、与设备不契合、延时设置错误、功能缺陷等问题。文章结合调试期间实际典型案例对DCS逻辑组态的优化与修改进行归纳总结,为基建机组逻辑设计与调试提供参考。     

汽车铝合金阀盖压力铸造模具数字设计与制造

制造过程实质上是信息采集、传输、处理及应用的过程.将制造信息数字化,用数字信息驱动制造系统完成造物的过程称为数字制造.数字制造不仅能提高制造效率而且能显著降低制造成本.本文以汽车制动系阀盖为例介绍了基于Pro/E的压力铸造模具的开发过程,分析了压力铸造模具数字设计与制造的特点.     

Study on diffusion welding SiCp/ZL101 with Cu interlayer

Through the vacuum diffusion welding SiCp/ZL101 aluminum with Cu interlayer,the effect of welding parame-ter and the thickness of Cu on the welded joint property was investigated,and the optimal welding parameters were putforward at the same time.The microstructure of joint was analyzed by means of optical-microscope,scanning electron mi-croscope in order to study the relationship between the macro-properties of joint and the microstructure.The results showthat diffusion welding with Cu interlayer could be used for welding aluminum matrix composites SiCp/ZL101 successfully.     

Distribution and segregation of solute in Al2O3 short fiber reinforced Al-5%Cu alloy containing La by squeeze casting

Al2O3 short fiber reinforced La-bearing Al-5%Cu alloy was fabricated by squeeze casting, and the solidified structure and the solute segregation during alloy solidification were studied. The results indicated that La has been enriched near the interface which is favorable to improve the wettability between the fiber and Al alloy, but the RE-rich phase was not formed at the interface. At the end of the solidification of the composites, the change of the solute in the surplus liquid phase results in the type of matrix alloy being changed because of the selective crystallization, and the segregation at the interface is finally formed. There is no special influence by La on the Cu segregation in the matrix alloy.     

脲醛呋喃树脂中氮含量的测定

脲醛呋喃树脂中的含氮量,一般采用克氏定氮法,方法繁琐,费时较长,不利于快速分析的要求,本文利用气相色谱法对脲醛呋喃树脂中的氮含量进行分析测定,并建立了测定方法.方法简捷、快速、重现性好,加标回收率在100.8～109.0之间,准确度较高,可很好的满足工业生产中快速分析的要求.