排序方式: 共有23条查询结果,搜索用时 15 毫秒
11.
为了解决石油化工企业传统焊接工艺评定管理效率底下、准确性低的问题,按照NB/T 47014—2011标准中焊接工艺规程的格式,实现了预焊接工艺规程(pWPS)、焊接工艺评定(PQR)和工艺卡(WPS)的在线编制和管理功能并设计了完善的权限控制机制,结合企业的实际工作流程实现工艺文件的在线审核管理功能、在线工艺评定的申请领用及作废被查等功能,实现了完善的焊接工艺评定在线管理系统。通过在企业中的部署使用和不断完善,证明了该系统在工艺文件数字化和提高工艺评定管理水平方面的突出作用。 相似文献
12.
介绍了“焊接工艺指导书”(WPS)和“焊接工艺评定报告、(PQR),详细介绍了烛接工艺评定的执行情况,指出为确保WPS和PQR切实指导焊接施工,施工部门必须由焊接专业人员进行管理,还需要有必要的监督措施来督促实施。 相似文献
13.
14.
Katja Seipel Yvo Brügger Harpreet Mandhair Ulrike Bacher Thomas Pabst 《International journal of molecular sciences》2022,23(20)
In October 2020, the FDA granted regular approval to venetoclax (ABT-199) in combination with hypomethylating agents for newly-diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or in patients with comorbidities precluding intensive chemotherapy. The treatment response to venetoclax combination treatment, however, may be short-lived, and leukemia relapse is the major cause of treatment failure. Multiple studies have confirmed the upregulation of the anti-apoptotic proteins of the B-cell lymphoma 2 (BCL2) family and the activation of intracellular signaling pathways associated with resistance to venetoclax. To improve treatment outcome, compounds targeting anti-apoptotic proteins and signaling pathways have been evaluated in combination with venetoclax. In this study, the BCL-XL inhibitor A1331852, MCL1-inhibitor , dual PI3K-mTOR inhibitor bimiralisib (PQR309), BMI-1 inhibitor unesbulin (PTC596), MEK-inhibitor trametinib (GSK1120212), and STAT3 inhibitor C-188-9 were assessed as single agents and in combination with venetoclax, for their ability to induce apoptosis and cell death in leukemic cells grown in the absence or presence of bone marrow stroma. Enhanced cytotoxic effects were present in all combination treatments with venetoclax in AML cell lines and AML patient samples. Elevated in vitro efficacies were observed for the combination treatment of venetoclax with A1331852, S63845 and bimiralisib, with differing response markers for each combination. For the venetoclax and bimiralisib combination treatment, responders were enriched for IDH2 and FLT3 mutations, whereas non-responders were associated with PTPN11 mutations. The combination of PI3K/mTOR dual pathway inhibition with bimiralisib and BCL2 inhibition with venetoclax has emerged as a candidate treatment in IDH2- and FLT3-mutated AML. S63845相似文献
15.
通过实际测量数据,分析比较了数字压缩录像机常用的三种测试方法,认为使用动态图像测试序列更为有效便捷,并对测试中发现的现象进行了研究探讨。 相似文献
16.
通过对图像格式的比较,说明在数字电视节目制作中数据处理对图像质量的影响,从而更好地避免格式转换过程中图像质量的下降。 相似文献
17.
在高标清系统中,视频信号需要模式转换和编解码处理,针对系统各个环节中视频信号的损伤,研究采用主客观评价结合的方式对视频质量进行综合评定.通过对不同品牌的上下变换器和编解码器输出的视频质量进行比较和分析,了解各品牌设备在信号处理中的优缺点,为今后系统应用及设备选型提出可靠的建议. 相似文献
18.
19.
对在役的316L不锈钢管线的局部减薄部位,采用套管修复方法对其修复。根据APISTD1104--2005标准,在自建的在役焊接动态实验装置上,对316L不锈钢套管修复焊接工艺进行评定。通过对套管环缝进行刻槽锤断试验,套管纵缝进行刻槽锤断试验、面弯和背弯试验,其检验结果均符合焊接工艺评定要求,说明制订的焊接工艺可对316L不锈钢进行在役焊接,该工艺对海洋平台不锈钢管线的在役焊接修复提供一定的指导意义。 相似文献
20.