Injectable silk/hydroxyapatite nanocomposite hydrogels with vascularization capacity for bone regeneration

Localized and sustained osteogenic-angiogenic stimulation to bone defects is critical for effective bone repair.Here,desferrioxamine(DFO)was loaded on silk fibroin nanofibers and blended with hydroxyapatite nanorods(HA),forming injectable DFO-loaded silk fibroin-HA nanocomposite hydrogels.The composite hydrogels remained homogeneous distribution of HA with high ratio(60%)and also higher stiffness than that of pure silk fibroin nanofiber hydrogels,which provided stable osteogenic stimulation niches for tissue regeneration.Without the scarify of injectability,the hydrogels achieved slow delivery of DFO for above 60 days,resulting in suitable angiogenesis in vitro and in vivo and better osteogenesis than DFO-free systems.Compared to previous injectable silk fibroin-HA hydrogels,the introduction of vascularization capacity further stimulated the osteogenic differentiation of stem cells and accelerated new bone formation.Quicker and better bone healing were detected at defect sites after the injection of DFO-loaded nanocomposite hydrogels,indicating the effective synergistic effect of osteogenic and angiogenic cues.This work provides a simple and effective strategy of introducing angiogenic cues to bone matrices.We believe that the injectable nanocomposite hydrogels are suitable for the regeneration of bone tissues.     

Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds’ Healing

Globally, wound infection is considered to be one of the major healthcare problems, with bacterial infections being the most critical threat, leading to poor and delayed wound healing, and even death. As a superbug, methicillin-resistant Staphylococcus aureus (MRSA) causes a profound hazard to public health safety, prompting us to search for alternative treatment approaches. Herein, the MTT test and Hoechst/propidium iodide (PI) staining demonstrated that PD was slightly less toxic to human fibroblasts including Human keratinocytes (HaCaT) cell line than Silver sulfadiazine (SSD), and Vancomycin (Van). In the MRSA-infected wound model, PD hydrogel (1%, 2.5%) was applied with for 14 days. The wound healing of PD hydrogel groups was superior to the SSD, Van, and control groups. Remarkably, the experimental results showed that PD reduced the number of skin bacteria, reduced inflammation, and upregulated the expression of PCNA (keratinocyte proliferation marker) and CD31 (angiogenesis manufacturer) at the wound site by histology (including hematoxylin–eosin (HE) staining, Masson staining) and immunohistochemistry. Additionally, no toxicity, hemocompatibility or histopathological changes to organs were observed. Altogether, these results suggested the potential of PD hydrogel as a safe, effective, and low toxicity hydrogel for the future clinical treatment of MRSA-infected wounds.     

机制砂空隙率软测量模型构建及试验研究

机制砂的空隙率是衡量混凝土性能的重要指标。空隙率的在线检测能够提升混凝土性能。现有的测量方法无法对机制砂空隙率进行在线检测。因此,提出一种通过动态图像法建立软测量模型,进而实现空隙率在线检测的方法。首先,采用基于动态图像法原理构建的机制砂形态测量平台来采集机制砂图像。然后,计算机制砂的关键形态参数,选择合适的软测量模型算法。最后,构建并比较不同软测量模型的预测性能。对比结果显示,随机森林模型的准确率最高,预测值和试验值最大误差为0.6%。相较于传统方法,该方法可在机制砂生产线中在线检测空隙率,有效提升混凝土性能。     

一种基于软PLC技术的通用可编程软件系统设计及实现

针对传统PLC难以构建开放硬件体系结构及性价比增长缓慢的缺点,提出了一种基于软PLC技术的通用可编程软件系统。该系统不仅符合IEC61131-3标准,支持标准定义的5种编程语言,而且用软件实现le 传统硬件PLC的控制功能。     

钴湿法冶炼萃取过程中的组分含量软测量

提出了一种钴湿法冶炼萃取组分含量混合建模方法.该模型由基于物料衡算关系的动态机理模型与基于萃取平衡实验数据的RBF神经网络模型组成.机理模型作为描述过程动态行为的整体框架,RBF神经网络用来辨识机理模型中的未知函数关系.在上述混合模型的基础上,还提出了一种模型校正策略,进一步提高了模型的精确性.将所建立的混合模型应用于实际湿法冶炼生产过程中,结果表明该方法具有良好的估计性能.     

On discovery of soft associations with “most” fuzzy quantifier for item promotion applications

In item promotion applications, there is a strong need for tools that can help to unlock the hidden profit within each individual customer’s transaction history. Discovering association patterns based on the data mining technique is helpful for this purpose. However, the conventional association mining approach, while generating “strong” association rules, cannot detect potential profit-building opportunities that can be exposed by “soft” association rules, which recommend items with looser but significant enough associations. This paper proposes a novel mining method that automatically detects hidden profit-building opportunities through discovering soft associations among items from historical transactions. Specifically, this paper proposes a relaxation method of association mining with a new support measurement, called soft support, that can be used for mining soft association patterns expressed with the “most” fuzzy quantifier. In addition, a novel measure for validating the soft-associated rules is proposed based on the estimated possibility of a conditioned quantified fuzzy event. The new measure is shown to be effective by comparison with several existing measures. A new association mining algorithm based on modification of the FT-Tree algorithm is proposed to accommodate this new support measure. Finally, the mining algorithm is applied to several data sets to investigate its effectiveness in finding soft patterns and content recommendation.     

WCDMA系统下行功率控制方案

功率控制是WCDMA移动通信系统中提高系统容量和保证链路通信质量的关键技术。传统的下行链路功率控制方案的实现主要存在两个问题:基站发射功率的失衡和下行链路干扰过大。为了解决这两个问题,主要介绍了两种新的下行功率控制方案:站选择分集发射和调整TPC频率功率控制。其中前一种方案用于减小下行链路干扰,后一种方案用于恢复基站发射功率的平衡。研究表明,利用上述方案能够有效减小软切换中继站发射功率的差异以及下行链路干扰,从而提高了系统容量。     

Comparison of conventional and soft computing-based power control methods in mobile communications systems

 In this paper, we give a comparison between the conventional power control scheme and soft computing-based approaches in a mobile communications application. At the base station, the `bang–bang' control strategy and a neural network-based prediction control method are employed. In addition, full power command transmission mode, single-bit command transmission mode, and fuzzy logic-based power command enhancement unit are considered. Based on simulation experiments, we quantitatively evaluate the performance of various combinations of these control methods and command transmission modes. Conclusions on the optimal configuration are finally drawn.     

等离子体软X射线源及其用于微细加工的探讨

喷气式Ｚ箍缩等离子体装置可产生较强的脉冲软Ｘ射线，利用此Ｘ射线进行了初曝光实验。另外，本文对此装置用于微细加工从理论上进行了初步探讨。     

PEO/PVA水凝胶伤口敷料的毒性和疗效评价

为了证价经冻融循环处理和电子束辐射交联接技术术合成的聚氧化乙烯与聚乙烯醇（ＰＥＯ／ＰＶＡ）混合物水凝胶伤口敷料的性能,研究了该水凝胶膜对机体和细胞的毒性以及对皮肤伤口的愈合作用。毒性作用通过仇性全身毒性试验、细胞毒性试验和皮肤斑贴试验检测。细胞毒性试验应用高敏感性的成纤维细胞持续培养７ｄ的ＲＰＭＩ－１６４０２培养系统,检测细胞生长抑制和镜下细胞形态学变化。结果显示,ＰＥＯ／ＰＶＡ水凝胶敷料没有引起