关于金属蜗壳和座环打压试验必要性的讨论

在分析构件应力状态基础上，通过总结已做的打压试验，从设计、制造和安装出发，考虑蜗壳和座环今后结构的发展趋势，参照国外近年来发表的有关文献，作者提出：在保证焊接质量并认真进行焊缝检验的条件下不可不进行劳民伤财的蜗壳座环现场打压试验。     

一个英汉机器翻译实验系统的设计

在分析目前国内外机器翻译系统的技术和方法的基础上,本文提出了适合于以电力科技英语为翻译对象的英汉机器翻译实验系统的设计方法,即以定子句语法和格语法为基础进行算法设计。利用人工智能语言 PROLOG 加以实现。     

A POLE Splice Site Deletion Detected in a Patient with Biclonal CLL and Prostate Cancer: A Case Report

Chronic lymphocytic leukemia (CLL) is considered a clonal B cell malignancy. Sporadically, CLL cases with multiple productive heavy and light-chain rearrangements were detected, thus leading to a bi- or oligoclonal CLL disease with leukemic cells originating either from different B cells or otherwise descending from secondary immunoglobulin rearrangement events. This suggests a potential role of clonal hematopoiesis or germline predisposition in these cases. During the screening of 75 CLL cases for kappa and lambda light-chain rearrangements, we could detect a single case with CLL cells expressing two distinct kappa and lambda light chains paired with two separate immunoglobulin heavy-chain variable regions. Furthermore, this patient also developed a prostate carcinoma. Targeted genome sequencing of highly purified light-chain specific CLL clones from this patient and from the prostate carcinoma revealed the presence of a rare germline polymorphism in the POLE gene. Hence, our data suggest that the detected SNP may predispose for cancer, particularly for CLL.     

Distillation technology – still young and full of breakthrough opportunities

Throughout history, distillation has been the most widespread separation method. However, despite its simplicity and flexibility, distillation still remains very energy inefficient. Novel distillation concepts based on process intensification, can deliver major benefits, not just in terms of significantly lower energy use, but also in reducing capital investment and improving eco‐efficiency. While very likely to remain the separation technology of choice for the next decades, there is no doubt that distillation technology needs to make radical changes in order to meet the demands of the energy‐conscious modern society. This article aims to show that in spite of its long age, distillation technology is still young and full of breakthrough opportunities. Moreover, it provides a broad overview of the recent developments in distillation based on process intensification principles, for example heat pump assisted distillation (e.g. vapor compression or compression–resorption), heat‐integrated distillation column, membrane distillation, HiGee distillation, cyclic distillation, thermally coupled distillation systems (Petlyuk), dividing‐wall column, and reactive distillation. These developments as well as the future perspectives of distillation are discussed in the context of changes towards a more energy efficient and sustainable chemical process industry. Several key examples are also included to illustrate the astonishing potential of these new distillation concepts to significantly reduce the capital and operating cost at industrial scale. © 2013 Society of Chemical Industry     

Pharmacogenetics Informed Decision Making in Adolescent Psychiatric Treatment: A Clinical Case Report

Advances made in genetic testing and tools applied to pharmacogenetics are increasingly being used to inform clinicians in fields such as oncology, hematology, diabetes (endocrinology), cardiology and expanding into psychiatry by examining the influences of genetics on drug efficacy and metabolism. We present a clinical case example of an adolescent male with anxiety, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder who did not tolerate numerous medications and dosages over several years in attempts to manage his symptoms. Pharmacogenetics testing was performed and DNA results on this individual elucidated the potential pitfalls in medication use because of specific pharmacodynamic and pharmacokinetic differences specifically involving polymorphisms of genes in the cytochrome p450 enzyme system. Future studies and reports are needed to further illustrate and determine the type of individualized medicine approach required to treat individuals based on their specific gene patterns. Growing evidence supports this biological approach for standard of care in psychiatry.     

恒湿文物展柜用吸附式空气取水方法

博物馆恒湿文物展柜的湿度控制至关重要,为实现展柜的自动恒湿功能,本文基于吸附式空气取水原理,提出了一种将环境水汽自动补充至恒湿文物展柜系统水箱的方法,并搭建了相应的小型空气取水装置,证明了该方法的可行性;同时,构建了传热传质耦合的空气取水装置数学模型,在获取环境温湿度对装置取水量的影响规律后,分析加热功率和吸附床结构对装置单位能耗取水量的影响;此外,为便于装置的后期推广应用,提出了两个基于吸附床高度和直径的量纲为1参数。结果表明：进口空气的温度对取水量影响较小,但进口空气的湿度对取水量影响较明显,取水量随着湿度增加而增加;加热功率存在最优值,单位能耗取水量随着加热功率先增大后减小;在当前几何参数组合下,两个量纲为1参数η=2、β=4时,装置的单位能耗取水量最高。     

高效沉淀池的工艺设计与应用案例

该文阐述了高效沉淀池的工艺原理和特点,介绍了工艺使用条件,展望了该工艺的应用前景;并通过对某污水处理厂深度处理部分高效沉淀池的工艺设计,列举了详细的设计参数、运行效能,为设计研究工作者提供借鉴。     

内骨架耐热橡胶密封圈的研制

介绍了内骨架耐热橡胶密封圈的配方设计、产品和模具设计、生产工艺及产品性能特点。主体橡胶选用三元乙丙橡胶。适量加入粘合剂用以提高与金属骨架的粘接力。产品截面设计成G形结构。外侧橡胶圆环为密封唇部,内侧埋设金属骨架并预留2个胀紧孔,安装时定位准确、密封压力大。金属骨架截面设计成横T形结构减小应力集中提高粘接力,外侧增设螺纹和沟槽,增大了橡胶与金属骨架的接触面。该产品具有耐热性能好、结构合理、使用寿命长等特点。     

基于MFI的泵壳注塑工艺分析

对泵壳结构进行了分析,针对其壁薄、腔深,边缘易缺料、整体易翘曲变形的特点,设计了泵壳的二浇口和三浇口两种浇注系统方案。通过Moldflow软件比较各方案的充模时间、塑料流动前端温度和气穴等,选取了采用1个主流道、均匀分布的3个二、三级分流道的三浇口方案为泵壳浇注系统,其注塑时注射压力为63.9532 MPa,锁模力为47.5293 t。在此基础上设计了注塑模具的5回路冷却系统,并对泵壳进行了翘曲变形分析。达到了由模具冷却和材料取向引起的塑件翘曲变形近乎零的效果。     

基于事例推理的主生产计划系统

为了快速、准确地获得最佳的主生产计划 ,在分析主生产计划系统中关键问题的基础上 ,探讨了基于事例推理技术在资源需求求解中的运用 ,提出了基于事例推理的主生产计划系统基本结构。基于事例推理技术的应用 ,加速了资源需求剖面的形成和求解的正确性 ,从而提高了主生产计划系统的效率和可靠性