A study of structural determinants in the interleukin-1 fold

The structures of interleukin-1ß, basic fibroblastgrowth factor and Erythrina trypsin inhibitor have been analysedin order to determine whether the hydrophobic core remains conserved,even when the structures have extremely low sequence similarities.We find that there are significant differences in the way eachprotein achieves a satisfactory arrangement of core residuesand that positions which contribute to the core of one structureare not guaranteed to contribute to the integrity of another.Furthermore, the side-chain packing arrangements of these coreresidues vary significantly between the three structures. Duringthis analysis the side-chain rotamers for three independentlydetermined interleukin-1ß structures were also compared.It was found that although buried residues are generally inagreement the remaining residues frequently occupy differentrotamers in the three structures. This suggests that althoughmeaningful studies are possible for buried side-chains the resultsobtained from equivalent analyses of accessible residues shouldbe treated with caution. These results are discussed with specificreference to the optimization of side-chain packing in proteinsof known structure.     

改进的细菌觅食优化算法求解0-1背包问题

细菌觅食优化算法作为一种新兴的智能优化算法,一般用来解决连续域的问题。为了解决离散域问题,提出了一种改进的细菌觅食优化算法。采用线性递减的思想和随机的游动长度代替固定步长和随机游动方向,改进了趋向性操作方案,并将其应用于解决0-1背包问题。将改进的细菌觅食优化算法与遗传算法、离散粒子群优化算法及基本的离散化细菌觅食优化算法分别在小规模和大规模的0-1背包问题上进行了仿真比较,表明了改进的细菌觅食优化算法能取得较好的效果,寻优能力强。     

Loss of Curing Agent During Thin Film (Droplet) Curing of Thermoset Material

Recently, it has been reported by our group and others^1.2 that loss of curing agent is encountered during the curing of small droplets or thin films of amine cured epoxies. In our earlier study³ results were reported on loss of curing agent in small droplets used in conducting the rnicrobond, single fiber test for determination of interfacial shear strength (ISS). It was reported that use of a volatile curing agent (meta-phenylene diamine (m-PDA) with DGEBA resin) resulted in increasing amounts of curing agent being lost (as measured by T₈ of the cured droplets) with decreasing droplet size during the processing procedure. Droplets smaller than 150 micrometers were seen to lose up to 40% of the curing agent leading to alteration of the mechanical properties of the droplet and, therefore, causing measured values of ISS to be exceedingly low. Use of a less volatile curing agent (Jeffamine 700, a polyether diamine, Texaco Specialty Chemicals) in combination with DGEBA resin produced results which indicated that loss of curing agent was not occuring. This study was undertaken to show the relationships between film (or droplet) size and the amount of curing agent lost (during the processing) for three different aminecured epoxy systems.     

基于视觉感知机制的织物疵点轮廓检测

针对传统人工织物疵点检测存在的误检及低效等问题,提出了一种基于视觉感知机制的自适应织物疵点轮廓检测方法.首先,模拟视觉系统中视网膜感受野对视觉信息的处理机制对织物疵点图像进行滤波及疵点增强;其次,依据初级视皮层(V1)区对视觉信息响应的方向选择性机制构建织物疵点图像边缘检测模型,实现对织物疵点图像的边缘检测.最后,采用自适应阈值选择的方法对检测到的边缘进行二次处理,获得织物图像疵点的轮廓.为验证本文方法的有效性和准确性,对4类织物疵点图像进行测试,并定性和定量两方面进行比较分析,结果表明文中提出的方法能够较好地检测出织物疵点轮廓信息,不仅可以得到质量较高的织物疵点轮廓图像,而且在整个检测过程中能够自适应的选择参数,避免受人的主观因素影响,具有实际的应用价值.     

求解0-1背包问题的混合贪婪遗传算法

求解0-1背包问题（KP）的最优解的时候,传统遗传算法（GA）的局部求精能力不足而简单局部搜索算法的全局探索能力有限,针对上述问题,将这两个算法整合并提出了混合贪婪遗传算法（HGGA）。在GA全局搜索框架下增加局部搜索模块,并改进传统仅基于物品价值密度的修复算子,增加基于物品价值的贪婪混合选项,从而加速寻优过程。HGGA一方面引导种群在进化的优质解空间中展开精细搜索,另一方面依靠GA的经典操作算子开拓全局搜索空间,从而达到算法求精能力和开拓能力的良好平衡。HGGA分别在三组数据上做了测试,结果表明在第一组15个测试用例中的12个上,HGGA能够百分百找到最优解,成功率达到80%;在第二组小规模数据集上,HGGA的性能明显好于其他同类GA和其他元启发算法;在第三组大规模数据集上,HGGA较其他元启发式算法具有更好的稳定性和高效性。     

基于FPGA的TDM over IP的设计

设计一种TDM over IP的技术系统。该系统用FPGA将E1数据包通过串并转换到千兆以太网数据包,经IP网传输到终端设备,再通过并串转换将以太网数据包转换成E1数据包完成传输。经过软件和硬件测试验证了此系统在千兆以太网上传输的可行性,系统没有出现误码,固有输出抖动是0.55UI,最大峰值抖动指标均满足ITU-G.823标准要求。     

四川盆地海相页岩气富集条件及勘探开发有利区

历经十余年探索实践,四川盆地海相页岩气勘探取得了一系列进展,锁定五峰组—龙马溪组为最有利产层,提出了一批页岩气富集高产理论,形成了集地质评价、开发优化、优快钻井、体积压裂、工厂化作业、清洁开发等为一体的勘探开发技术,探明了万亿立方米级储量的页岩气大气田。时值中国页岩气勘探发展的重要节点,回顾四川盆地海相页岩气勘探开发历程、梳理五峰组—龙马溪组页岩气在地质条件与富集规律上的成果认识、展望四川盆地海相页岩气勘探的重点接替领域,对推进盆地海相页岩气的勘探开发有积极意义。(1)四川盆地海相页岩气勘探开发经历了4个阶段：评层选区找目标阶段;浅层至中—深层先导试验阶段;浅层至中—深层示范区建设阶段;浅层至中—深层上产、深层评价、常压页岩气评价、立体开发评价、超深层和新层系探索阶段。(2)四川盆地五峰组—龙马溪组的沉积条件优越,深水陆棚相高有机质含量页岩呈连续稳定分布;页岩气主要赋存在有机孔隙中,页岩储层在纵向上集中发育,连续厚度大;川南地区和川东南涪陵区块的构造相对简单,气源持续补给、远离古/今剥蚀区和大型断裂逸散区是页岩气富集保存的有利区;目前,五峰组—龙马溪组的页岩气资源量为33.19×10<...     

基于稀疏强特征提取的三维地震数据完备方法

随着复杂储层地震资料特征筛选的机器学习技术的进步,如何有效地对参与地震属性优选和储层反演的地震样本进行采集和分析,成为目前智能地震预测领域的一个研究热点。目前的方法多着重于模型分类算法的改进,在标签的制作和采集方面不仅耗费大量时间进行人工标注,还存在标签不平衡情况下类内可靠性、类间平衡性不强等问题。为此,提出基于稀疏强特征提取的三维地震数据完备方法。首先,基于多数决原则的样本分割(Sample Segmentation Based on Majority Rule, SSMR)寻迹多尺度、多标签三维地震样本,进行采集、自动标注;然后,改进标签洗牌平衡方法(Improved Label Shuffling Balance Method, ILSB),通过“2+1”的样本增广平衡策略进行数据完备处理,改善样本采样不平衡性导致的模型训练偏向性;最后,利用基于最小L₁范数稀疏表示对奇异值分解结果进行强特征提取(Minimum L₁-norm Based Sparse Representation for Feature Extraction, L     

铸造铝合金轮毂T6热处理工艺的优化研究

研究了固溶时间、淬火停留时间及涂装烘烤工艺对A356合金铸造轮毂性能的影响规律并优化了T6热处理工艺，将淬火停留时间缩短到2h。研究表明：未涂装时优化工艺使合金抗拉强度达到240MPa，屈服强度达到181MPa。伸长率达到8％；涂装后抗拉强度达到262MPa，屈服强度达到179MPa，伸长率达到9％，接近并达到目前国内T6工艺的强度性能，超过了国内轮毂行业的强度性能标准，具有一定的生产实际意义。