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51.
Activity-directed synthesis (ADS) is a structure-blind, functional-driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses reactions with multiple possible outcomes, and allows many chemotypes to be evaluated in parallel. Resources are focused on bioactive molecules, which emerge in tandem with associated synthetic routes. Some of the future challenges for ADS are highlighted, including the realisation of an autonomous molecular discovery platform. The prospects for ADS to become a mainstream lead generation approach are discussed. 相似文献
52.
《Ceramics International》2020,46(15):23695-23705
Solid electrolytes are the key component in designing all-solid-state batteries. The Li1.3Al0.3Ti1.7(PO4)3 (LATP) structure and its derivatives obtained by doping various elements at Ti and Al site acts as good solid electrolytes. However, there is still scope for enhancing the ionic conductivity using simple precursors and preparation methods. In this study, the Li superionic conductors Li1.3Al0.3Ti1.7-xZrx(PO4)3 (LATZP) with 0 ≤ x ≤ 0.2 have been successfully prepared by the solid-state reaction route. The structural, morphological, and ionic transport properties were analyzed using several experimental techniques including powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and impedance spectroscopy (IS). The presence of two relaxation processes corresponding to grain and grain boundary was studied using various formalisms. We have observed that grain effects dominate at lower temperatures (<100 °C) while the grain boundary at higher temperatures (> 200 °C) on ionic conductivity. The relaxation mechanisms of grain and grain boundaries were investigated by the Summerfield scaling of AC conductivity. The highest total ionic conductivity of 2.48 × 10-4 S/cm at 150 °C and 5.50 × 10-3 S/cm at 250 °C was obtained for x = 0.1 in Li1.3Al0.3Ti1.6Zr0.1(PO4)3 sintered at 950 °C/6 h in the air. The ionic conductivity value was found to be higher than the ionic conductivity reported for LATP prepared via solid-state reaction mechanism using the same precursors and conditions. 相似文献
53.
The integration of planning and scheduling decisions in rigorous mathematical models usually results in large scale problems. In order to tackle the problem complexity, decomposition techniques based on duality and information flows between a master and a set of subproblems are widely applied. In this sense, ontologies improve information sharing and communication in enterprises and can even represent holistic mathematical models facilitating the use of analytic tools and providing higher flexibility for model building. In this work, we exploit this ontologies’ capability to address the optimal integration of planning and scheduling using a Lagrangian decomposition approach. Scheduling/planning sub-problems are created for each facility/supply chain entity and their dual solution information is shared by means of the ontological framework. Two case studies based on a STN representation of supply chain planning and scheduling models are presented to emphasize the advantages and limitations of the proposed approach. 相似文献
54.
Simona Renda Antonio Ricca Vincenzo Palma 《International Journal of Hydrogen Energy》2021,46(22):12117-12127
This paper reports the preparation and the evaluation of the performance of Ni-based powder catalysts with low nickel loading on the CO2 methanation reaction, that is an integral part of the power-to-gas (PtG) technology. CeO2, CeZrO4 and CeO2/SiO2 were selected as possible supports, and the results of this first screening pointed out that 10%Ni/CeO2 catalyst could offer the best reaction performances because of ceria's peculiar characteristics. Moreover, the promotion of this promising formulation with the addition of a small amount of noble metals (Pt, Ru, Rh) was investigated, showing that platinum in particular can enhance the catalyst performances. A further study related to the noble metal loading pointed out that platinum and ruthenium have a different optimum loading condition: this result, together with the activity tests performed on monometallic formulations with only the noble metal, suggested that the two metals are able to catalyse two different reactions, thus promoting two different reaction mechanisms. 相似文献
55.
Real‐time monitoring by proton relaxometry of radical polymerization reactions of acrylamide in aqueous solution
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Elton Jorge da Rocha Rodrigues Roberto Pinto Cucinelli Neto Pedro José Oliveira Sebastião Maria Inês Bruno Tavares 《Polymer International》2018,67(6):675-683
The potential of time‐domain nuclear magnetic resonance (TD‐NMR) for the real‐time monitoring of solution radical polymerizations is demonstrated. A model system composed of a redox‐pair initiator system, acrylamide as monomer and water as solvent was investigated. A second‐generation continuous wave free precession technique was employed to measure the longitudinal relaxation time constant (T1) of the samples throughout the polymerization reactions. This parameter was shown to be sensitive to the reactant feed free‐radical enhancement of the water molecule relaxation time, making it a good probe to monitor monomer conversion in real time in an automated, non‐destructive fashion. It was found that the T1 value was better than the transverse relaxation time constant (T2) for describing the evolution of the polymerization reactions, due to its greater sensitivity to paramagnetic effects. The TD‐NMR signal variation observed was linked to the formation, propagation and termination steps of the radical polymerization kinetics scheme. These first results may contribute to the application of real‐time monitoring of radical polymerization reactions employing low‐cost and robust TD‐NMR spectrometers. © 2018 Society of Chemical Industry 相似文献
56.
ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of
autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which,
through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are
engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an
important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts
autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the
regulation of endoplasmic reticulum (ER)–Golgi trafficking in neurons, stimulates phosphopentose pathway to help
NADPH (nicotinamide adenine dinucleotide phosphate hydrogen) production, and acts as a duplex regulator in type
I IFN (type I interferon) induced innate immune response. Considering the importance and diversity of ULK1 in
various biological processes, this review aims to present a comprehensive overview of autophagy and non-autophagy
related functions of ULK1 in a variety of human physiological, pathological, and disease processes. 相似文献
57.
58.
Sebastian Sjoqvist Kentaro Otake Yoshihiko Hirozane 《International journal of molecular sciences》2020,21(24)
There is a lack of reliable biomarkers for disorders of the central nervous system (CNS), and diagnostics still heavily rely on symptoms that are both subjective and difficult to quantify. The cerebrospinal fluid (CSF) is a promising source of biomarkers due to its close connection to the CNS. Extracellular vesicles are actively secreted by cells, and proteomic analysis of CSF extracellular vesicles (EVs) and their molecular composition likely reflects changes in the CNS to a higher extent compared with total CSF, especially in the case of neuroinflammation, which could increase blood–brain barrier permeability and cause an influx of plasma proteins into the CSF. We used proximity extension assay for proteomic analysis due to its high sensitivity. We believe that this methodology could be useful for de novo biomarker discovery for several CNS diseases. We compared four commercially available kits for EV isolation: MagCapture and ExoIntact (based on magnetic beads), EVSecond L70 (size-exclusion chromatography), and exoEasy (membrane affinity). The isolated EVs were characterized by nanoparticle tracking analysis, ELISA (CD63, CD81 and albumin), and proximity extension assay (PEA) using two different panels, each consisting of 92 markers. The exoEasy samples did not pass the built-in quality controls and were excluded from downstream analysis. The number of detectable proteins in the ExoIntact samples was considerably higher (~150% for the cardiovascular III panel and ~320% for the cell regulation panel) compared with other groups. ExoIntact also showed the highest intersample correlation with an average Pearson’s correlation coefficient of 0.991 compared with 0.985 and 0.927 for MagCapture and EVSecond, respectively. The median coefficient of variation was 5%, 8%, and 22% for ExoIntact, MagCapture, and EVSecond, respectively. Comparing total CSF and ExoIntact samples revealed 70 differentially expressed proteins in the cardiovascular III panel and 17 in the cell regulation panel. To our knowledge, this is the first time that CSF EVs were analyzed by PEA. In conclusion, analysis of CSF EVs by PEA is feasible, and different isolation kits give distinct results, with ExoIntact showing the highest number of identified proteins with the lowest variability. 相似文献
59.
60.
《International Journal of Hydrogen Energy》2020,45(16):9546-9554
Hierarchical composites represent a class of efficient electrocatalysts for renewable energy storage and conversion technologies owing to the porous structure and additional exposure of metal sites. Herein, a Ni-based metal organic frameworks (MOFs) (marked as Ni-BDC, BDC stands for 1,4-benzenedicarboxylic acid) nanosheet is successfully fabricated on hydroxyl iron oxide (FeOOH) array with carbon fiber cloth (CFC) as substrate. Benefit from the coordination tuning synergistic effect of the distinct chemical composition and the hierarchical structure for fast mass transportation, the as-obtained FeOOH@Ni-BDC illustrates excellent catalytic ability for electrochemical water oxidation with low overpotential of 270 mV to reach 10 mA/cm2 current and good durability in alkaline electrolyte. The novelty of this work lies in the modulation of electronic structure of the FeOOH with Ni-BDC through coordination effect to enhance the activity of the hierarchical composite electrocatalyst. This work is expected to guide the preparation of efficient electrocatalyst for new type alternative energy sources exploitation in near future. 相似文献