基于AD7746的电容法间隙测量应用系统研究

为精确测量航空发动机部件间隙,针对电容法间隙测量进行了应用研究,重点设计了基于可编程电容—数字转换器AD7746的电容法间隙测量应用系统。采用驱动电缆法等措施,以减小寄生电容,提高抗干扰能力,并通过对AD7746内部可编程寄存器的补偿设置实现宽范围、高精度测量。该系统在自行设计的实验台架上进行多次实验,表明系统具有较好的线性度、重复性和较高的测量精度。最后,提出了电容法测量发动机叶尖间隙的方案。     

Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles

A major clinical translational challenge in nanomedicine is the potential of toxicity associated with the uptake and long-term retention of non-degradable nanoparticles (NPs) in major organs.The development of inorganic NPs that undergo renal clearance could potentially resolve this significant biosafety concern.However,it remains unclear whether inorganic NPs that can be excreted by the kidneys remain capable of targeting tumors with poor permeability.Glioblastoma multiforme,the most malignant orthotopic brain tumor,presents a unique challenge for NP delivery because of the blood-brain barrier and robust blood-tumor barrier of reactive microglia and macroglia in the tumor microenvironment.Herein,we used an orthotopic murine glioma model to investigate the passive targeting of glutathione-coated gold nanoparticles (AuNPs) of 3 nm in diameter that undergo renal clearance and 18-nm AuNPs that fail to undergo renal clearance.Remarkably, we report that 3-nm AuNPs were able to target intracranial tumor tissues with higher efficiency (2.3x relative to surrounding non-tumor normal brain tissues) and greater specificity (3.0x)than did the larger AuNPs.Pharmacokinetics studies suggested that the higher glioma targeting ability of the 3-nm AuNPs may be attributed to the longer retention time in circulation.The total accumulation of the 3-nm AuNPs in major organs was significantly less (8.4x) than that of the 18-nm AuNPs.Microscopic imaging of blood vessels and renal-clearable AuNPs showed extravasation of NPs from the leaky blood-tumor barrier into the tumor interstitium.Taken together,our results suggest that the 3-nm AuNPs,characterized by enhanced permeability and retention,are able to target brain tumors and undergo renal clearance.     

Engineered microparticles based on drug–polymer coprecipitates for ocular-controlled delivery of Ciprofloxacin: influence of technological parameters

Abstract

Ciprofloxacin is a drug active against a broad spectrum of aerobic Gram-positive and Gram-negative bacteria, for the therapy of ocular infections. It requires frequent administrations owing to rapid ocular clearance and it is a good candidate for ocular controlled release formulations. The preparation of such drug release systems is still a challenge. Ionic interactions between ciprofloxacin and the polyelectrolytes chondroitin sulfate or lambda carrageenan result in coprecipitates that can act as microparticulate controlled release systems from which the drug is released after being displaced by the medium’s ions. In some formulations, Carbopol was added to improve the mucoadhesive properties. The aim of this research was the study of the influence of the technological parameters of the preparation method of coprecipitates on their particle size, with the goal of achieving particles engineered with a size suitable for the ocular administration. Technological parameters taken into account were: concentration of drug and polymer solutions utilized for the preparation of interaction products, possible use of surfactants (kind and concentration), temperature of the solutions and stirring during the process of preparation of the coprecipitates. Preliminary stability study tests were carried out to further characterize the leader formulation. Particle size in suspensions for ocular drug delivery is a critical parameter influencing the quality of the formulation. The results obtained from this study show that chondroitin sulfate coprecipitates present the best characteristics in terms of particle size suitable for ocular administration. A further improvement of the particle size characteristics has been obtained with the addition of surfactants.     

旋转状态下微波叶尖间隙传感器校准影响因素分析

主要针对应用于发动机叶尖间隙测量的微波叶尖间隙传感器的校准需求,对测量原理、传感器的校准原理等进行了详细阐述,并分析了转速和回缩值等对校准结果的影响。为微波叶尖间隙传感器的进一步优化设计及应用提供了数据依据。     

考虑通关水平的跨境物流服务供应链契约协调机制研究

为实现跨境物流服务供应链完全协调,运用Stackelberg博弈理论,构建由一个跨境物流服务供应商与一个物流服务集成商组成的二级供应链。采用因子分析法测度通关水平,分析通关水平对跨境物流服务供应链最优决策及协调运作的影响,设计可供跨境物流服务供应链完美协调的契约机制。研究表明,考虑通关水平使跨境物流服务供应链成员及供应链整体利润均得到提升;集中决策下跨境物流服务供应链整体利润总是高于分散决策;收益共享契约可实现跨境物流服务供应商及供应链整体决策的帕累托优化,但不能达到供应链的完全协调,而Nash协商改进的二部定价契约模型可实现供应链的完全协调。     

液力减振器结构异响发生的微过程分析

将液力减振器的工作循环划分成更细微的过程并相应地进行了力学分析,建立了相应的微分方程,并利用M ATLAB软件进行了仿真计算,分析计算结果与台架试验结果一致。结果表明,活塞与油液间的间隙碰撞、活塞与缸筒的静动摩擦力交变和阀片与活塞的粘附均导致对汽车液力减振器活塞的冲击,其进一步的传递将产生结构异响。     

具有随机系数和带间隙的自激振动问题的人工神经网络解法

利用人工神经网络技术(BP网络)研究具有随机系数和带有间隙的初轧机自激振动问题,提出了一种Runge-Kutta法和人工神经网络相结合的求解方法。即利用数值计算和BP网络建立随机系数和稳态振幅之间的关系,从而直接计算出稳态振幅的统计特性。计算结果表明:采用所提出的方法求解,通用性好且可提高计算精度,并得到了间隙与稳态振幅的均值有关,与标准离差无关的有用结论。     

节流性能优异的新型液体静压支承节流器

传统的液体静压支承节流器存在严重缺陷，性能不佳，不能消除支承间隙随外加载荷增加而剧减的缺点，严重影响其实际应用。新型节流器节流变量指数b≥3，能够保持节流器进油与油囊排油速度接近一致。此外，当有外加载荷作用于支承时，油囊压力会升高，迫使节流变量产生附加增量，从而弥补了因油囊压力升高而减少供油量与油囊增加的排油量。因此，新型节流器能够保证在有外加载荷作用时支承间隙变化很小或近于不变。新型节流器节流性能优良，结构简单，成本低廉，体积较小，具有实用价值。     

基于图像测量技术的装配间隙在线测量研究

装配间隙的在线检测是产品装配时经常遇到的问题,其测量精度应在0.02 mm以内。介绍了一种基于图像测量技术的在线测量方案,将间隙通过光学系统在CCD摄像机中成的像经由图像采集卡采集后送交图像测量软件处理和分析,由测量软件给出结果,并对该方案的测量误差做了分析。实验结果表明:测量误差在0.015mm以内,满足装配需要。